Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A

Administration of [2-14C]mevalonolactone to excised leaves of Acnistus breviflorus produced labelled withaferin A and jaborosalactone A. Degradation of the labelled withanolides allowed isolation of C-26. and in the case of withaferin A of C-1, both derived from C-2 of mevalonolactone. The relative...

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Autores principales: Monteagudo, E.S., Veleiro, A.S., Burton, G., Gros, E.G.
Formato: JOUR
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09320776_v42_n11_p1471_Monteagudo
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spelling todo:paper_09320776_v42_n11_p1471_Monteagudo2023-10-03T15:48:23Z Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A Monteagudo, E.S. Veleiro, A.S. Burton, G. Gros, E.G. Administration of [2-14C]mevalonolactone to excised leaves of Acnistus breviflorus produced labelled withaferin A and jaborosalactone A. Degradation of the labelled withanolides allowed isolation of C-26. and in the case of withaferin A of C-1, both derived from C-2 of mevalonolactone. The relative specific activity of these carbon atoms was consistent with our previous results indicating the partial cleavage of the side chain of a sterol precursor in the biosynthetic process leading to the withanolides. © 1987, Walter de Gruyter. All rights reserved. Fil:Monteagudo, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Veleiro, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gros, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09320776_v42_n11_p1471_Monteagudo
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description Administration of [2-14C]mevalonolactone to excised leaves of Acnistus breviflorus produced labelled withaferin A and jaborosalactone A. Degradation of the labelled withanolides allowed isolation of C-26. and in the case of withaferin A of C-1, both derived from C-2 of mevalonolactone. The relative specific activity of these carbon atoms was consistent with our previous results indicating the partial cleavage of the side chain of a sterol precursor in the biosynthetic process leading to the withanolides. © 1987, Walter de Gruyter. All rights reserved.
format JOUR
author Monteagudo, E.S.
Veleiro, A.S.
Burton, G.
Gros, E.G.
spellingShingle Monteagudo, E.S.
Veleiro, A.S.
Burton, G.
Gros, E.G.
Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
author_facet Monteagudo, E.S.
Veleiro, A.S.
Burton, G.
Gros, E.G.
author_sort Monteagudo, E.S.
title Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
title_short Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
title_full Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
title_fullStr Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
title_full_unstemmed Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
title_sort biosynthesis of withanolides in acnistus breviflorus chemical degradation of 14c-labelled jaborosalactone a and withaferin a
url http://hdl.handle.net/20.500.12110/paper_09320776_v42_n11_p1471_Monteagudo
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AT veleiroas biosynthesisofwithanolidesinacnistusbrevifloruschemicaldegradationof14clabelledjaborosalactoneaandwithaferina
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