Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection

Infection with Trypanosoma cruzi develops in three phases: acute, indeterminate or asymptomatic, and chronic phase (with cardiac or digestive manifestations). Moreover, transmission may occur from infected mothers to newborn, the so-called congenital form. In the present study, humoral responses aga...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Aznar, C., Lopez-Bergami, P., Brandariz, S., Mariette, C., Liegeard, P., Alves, M.d.C.d.D., Barreiro, E.L., Carrasco, R., Lafon, S., Kaplan, D., Miguez, H., Camacho, C., Levitus, G., Mariano Levin, J., Hontebeyrie, M.
Formato: JOUR
Materias:
Chagas disease diagnosis
Chagasic cardiomyopathy
Myocardites
Ribosomal P protein
Synthetic peptide
Trypanosoma cruzi
immunoglobulin m
parasite antibody
adult
article
blood donor
cardiomyopathy
chagas disease
congenital infection
controlled study
human
major clinical study
newborn
priority journal
trypanosoma cruzi
trypanosomiasis
Acute Disease
Animal
Antibodies, Protozoan
Argentina
Base Sequence
Blood Donors
Brazil
Chagas Cardiomyopathy
Chagas Disease
Chronic Disease
Diagnosis, Differential
Human
Immunoglobulin Isotypes
Infant, Newborn
Molecular Sequence Data
Ribosomal Proteins
Seroepidemiologic Studies
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09288244_v12_n3-4_p231_Aznar
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Infection with Trypanosoma cruzi develops in three phases: acute, indeterminate or asymptomatic, and chronic phase (with cardiac or digestive manifestations). Moreover, transmission may occur from infected mothers to newborn, the so-called congenital form. In the present study, humoral responses against T. cruzi total extract and against the 13 amino acid peptide named R-13 derived from the parasite ribosomal P protein, previously described as a possible marker of chronic Chagas heart disease, were determined pateints and in blood bank donors from endemic areas. While in sera from acute phase, only IgM anti-T.cruzi response was observed, both IgM and IgG anti-T. cruzi antibodies were detected in sera from congenitally infected newborns. The percentage of positive response in sera from blood bank donors was relatively high in endemic regions. Antibodies against the R-13 peptide were present in a large proportion of cardiac chagasic patients but were totally lacking in patients with digestive form of Chagas' disease. Furthermore, anti-R-13 positive responses were detected in congenitally infected newborns. © 1995.

Ejemplares similares