Metabo-Devo: A metabolic perspective of development
In the last years, several reports have established the notion that metabolism is not just a housekeeping process, but instead an active effector of physiological changes. The idea that the metabolic status may rule a wide range of phenomena in cell biology is starting to be broadly accepted. Thus,...
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todo:paper_09254773_v154_n_p12_Gandara2023-10-03T15:46:19Z Metabo-Devo: A metabolic perspective of development Gándara, L. Wappner, P. Bioenergetics Cell differentiation Metabolism Warburg effect adenosine triphosphate glucose transporter 1 glucose transporter 2 hexokinase hexokinase 2 lactate dehydrogenase lactate dehydrogenase A lactate dehydrogenase C pyruvate kinase pyruvate kinase M2 unclassified drug aerobic glycolysis biomass cancer cell cell differentiation cell energy cell growth cell migration cell proliferation developmental biology developmental stage DNA demethylation Drosophila ectoderm embryo development gene expression genetic transcription hematopoiesis histone methylation mitochondrion mitophagy nervous system development nonhuman oxidative phosphorylation oxygen consumption pluripotent stem cell priority journal protein synthesis retina development Review tissue growth In the last years, several reports have established the notion that metabolism is not just a housekeeping process, but instead an active effector of physiological changes. The idea that the metabolic status may rule a wide range of phenomena in cell biology is starting to be broadly accepted. Thus, current developmental biology has begun to describe different ways by which the metabolic profile of the cell and developmental programs of the organism can crosstalk. In this review, we discuss mechanisms by which metabolism impacts on processes governing development. We review the growing body of evidence that supports the notion that aerobic glycolysis is required in cells undergoing fast growth and high proliferation, similarly to the Warburg effect described in tumor cells. Glycolytic metabolism explains not only the higher ATP synthesis rate required for cell growth, but also the uncoupling between mitochondrial activity and bioenergetics needed to provide anabolism with sufficient precursors. We also discuss some recent studies, which show that in addition to its role in providing energy and carbon chains, the metabolic status of the cell can also influence epigenetic regulation of developmental processes. Although metabolic aspects of development are just starting to be explored, there is no doubt that ongoing research in this field will shape the future landscape of Developmental Biology. © 2018 Elsevier B.V. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09254773_v154_n_p12_Gandara |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Bioenergetics Cell differentiation Metabolism Warburg effect adenosine triphosphate glucose transporter 1 glucose transporter 2 hexokinase hexokinase 2 lactate dehydrogenase lactate dehydrogenase A lactate dehydrogenase C pyruvate kinase pyruvate kinase M2 unclassified drug aerobic glycolysis biomass cancer cell cell differentiation cell energy cell growth cell migration cell proliferation developmental biology developmental stage DNA demethylation Drosophila ectoderm embryo development gene expression genetic transcription hematopoiesis histone methylation mitochondrion mitophagy nervous system development nonhuman oxidative phosphorylation oxygen consumption pluripotent stem cell priority journal protein synthesis retina development Review tissue growth |
| spellingShingle |
Bioenergetics Cell differentiation Metabolism Warburg effect adenosine triphosphate glucose transporter 1 glucose transporter 2 hexokinase hexokinase 2 lactate dehydrogenase lactate dehydrogenase A lactate dehydrogenase C pyruvate kinase pyruvate kinase M2 unclassified drug aerobic glycolysis biomass cancer cell cell differentiation cell energy cell growth cell migration cell proliferation developmental biology developmental stage DNA demethylation Drosophila ectoderm embryo development gene expression genetic transcription hematopoiesis histone methylation mitochondrion mitophagy nervous system development nonhuman oxidative phosphorylation oxygen consumption pluripotent stem cell priority journal protein synthesis retina development Review tissue growth Gándara, L. Wappner, P. Metabo-Devo: A metabolic perspective of development |
| topic_facet |
Bioenergetics Cell differentiation Metabolism Warburg effect adenosine triphosphate glucose transporter 1 glucose transporter 2 hexokinase hexokinase 2 lactate dehydrogenase lactate dehydrogenase A lactate dehydrogenase C pyruvate kinase pyruvate kinase M2 unclassified drug aerobic glycolysis biomass cancer cell cell differentiation cell energy cell growth cell migration cell proliferation developmental biology developmental stage DNA demethylation Drosophila ectoderm embryo development gene expression genetic transcription hematopoiesis histone methylation mitochondrion mitophagy nervous system development nonhuman oxidative phosphorylation oxygen consumption pluripotent stem cell priority journal protein synthesis retina development Review tissue growth |
| description |
In the last years, several reports have established the notion that metabolism is not just a housekeeping process, but instead an active effector of physiological changes. The idea that the metabolic status may rule a wide range of phenomena in cell biology is starting to be broadly accepted. Thus, current developmental biology has begun to describe different ways by which the metabolic profile of the cell and developmental programs of the organism can crosstalk. In this review, we discuss mechanisms by which metabolism impacts on processes governing development. We review the growing body of evidence that supports the notion that aerobic glycolysis is required in cells undergoing fast growth and high proliferation, similarly to the Warburg effect described in tumor cells. Glycolytic metabolism explains not only the higher ATP synthesis rate required for cell growth, but also the uncoupling between mitochondrial activity and bioenergetics needed to provide anabolism with sufficient precursors. We also discuss some recent studies, which show that in addition to its role in providing energy and carbon chains, the metabolic status of the cell can also influence epigenetic regulation of developmental processes. Although metabolic aspects of development are just starting to be explored, there is no doubt that ongoing research in this field will shape the future landscape of Developmental Biology. © 2018 Elsevier B.V. |
| format |
JOUR |
| author |
Gándara, L. Wappner, P. |
| author_facet |
Gándara, L. Wappner, P. |
| author_sort |
Gándara, L. |
| title |
Metabo-Devo: A metabolic perspective of development |
| title_short |
Metabo-Devo: A metabolic perspective of development |
| title_full |
Metabo-Devo: A metabolic perspective of development |
| title_fullStr |
Metabo-Devo: A metabolic perspective of development |
| title_full_unstemmed |
Metabo-Devo: A metabolic perspective of development |
| title_sort |
metabo-devo: a metabolic perspective of development |
| url |
http://hdl.handle.net/20.500.12110/paper_09254773_v154_n_p12_Gandara |
| work_keys_str_mv |
AT gandaral metabodevoametabolicperspectiveofdevelopment AT wappnerp metabodevoametabolicperspectiveofdevelopment |
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1807320330698489856 |