Crystal and solution structures of 7-amino-actinomycin D complexes with d(TTAGBrUT), d(TTAGTT) and d(TTTAGTTT)

The formation of the complex of 7-amino-actinomycin D with potentially single-stranded DNA has been studied by X-ray crystallography in the solid state, by NMR in solution and by molecular modelling. The crystal structures of the complex with 5′-TTAG[Br5U]T-3′ provide interesting examples of MAD pha...

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Detalles Bibliográficos
Autores principales:	Alexopoulos, E., Jares-Erijman, E.A., Jovin, T.M., Klement, R., Machinek, R., Sheldrick, G.M., Usón, I.
Formato:	JOUR
Materias:	7 aminodactinomycin 7-aminoactinomycin D antineoplastic antibiotic dactinomycin drug derivative oligodeoxyribonucleotide article base pairing chemical structure chemistry crystallization electron spin resonance nuclear magnetic resonance X ray crystallography Antibiotics, Antineoplastic Base Pairing Crystallization Crystallography, X-Ray Dactinomycin Electron Spin Resonance Spectroscopy Models, Molecular Nuclear Magnetic Resonance, Biomolecular Oligodeoxyribonucleotides
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09074449_v61_n4_p407_Alexopoulos
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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