The action of the mast cell product tryptase on cyclooxygenase-2 (COX2) and subsequent fibroblast proliferation involves activation of the extracellular signal-regulated kinase isoforms 1 and 2 (erk1/2)

The mast cell product tryptase, via protease-activated receptor 2 (PAR2), induces cyclooxygenase-2 (COX2) and 15-deoxy-prostaglandin J2 (15d-PGJ2) synthesis. 15d-PGJ2, through the nuclear peroxisome proliferator activated receptor gamma (PPARγ), subsequently causes fibroblast proliferation. In this...

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Detalles Bibliográficos
Autores principales: Frungieri, M.B., Albrecht, M., Raemsch, R., Mayerhofer, A.
Formato: JOUR
Materias:
Ca 2+
cAMP
Cyclooxygenase-2
MAP kinases
Transcription factors
Tryptase
2 (2 amino 3 methoxyphenyl)chromone
cyclooxygenase 2
mitogen activated protein kinase 1
mitogen activated protein kinase inhibitor
phosphotransferase
prostaglandin derivative
protein c fos
stress activated protein kinase
tryptase
article
calcium cell level
cell proliferation
controlled study
DNA microarray
enzyme activation
enzyme activity
enzyme induction
enzyme mechanism
fibroblast
human
human cell
mast cell
priority journal
protein expression
protein phosphorylation
reverse transcription polymerase chain reaction
signal transduction
upregulation
Western blotting
Base Sequence
Calcium
Cell Proliferation
Cyclic AMP
Cyclooxygenase 2
Fibroblasts
Humans
Male
Mast Cells
Membrane Proteins
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Molecular Sequence Data
Prostaglandin-Endoperoxide Synthases
Protein Isoforms
Serine Endopeptidases
Signal Transduction
Tryptases
Up-Regulation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_08986568_v17_n4_p525_Frungieri
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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