A SPECT study of Parkinsonism in Alzheimer's disease
The authors examined the presence of significant regional cerebral blood flow (rCBF) differences between Alzheimer's disease (AD) patients with and without extrapyramidal signs (EPS). Nine patients with probable AD and EPS (resting tremor or rigidity and bradykinesia) and 9 AD patients without...
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_08950172_v7_n3_p308_Starkstein |
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todo:paper_08950172_v7_n3_p308_Starkstein2023-10-03T15:42:19Z A SPECT study of Parkinsonism in Alzheimer's disease Starkstein, S.E. Vazquez, S. Merello, M. Teson, A. Petracchi, M. Leiguarda, R. hexamethylpropylene amine oxime technetium tc 99m aged Alzheimer disease article bradykinesia brain blood flow clinical article cognitive defect extrapyramidal symptom female frontal lobe human left hemisphere male parietal lobe parkinsonism priority journal rigidity single photon emission computer tomography temporal lobe tremor The authors examined the presence of significant regional cerebral blood flow (rCBF) differences between Alzheimer's disease (AD) patients with and without extrapyramidal signs (EPS). Nine patients with probable AD and EPS (resting tremor or rigidity and bradykinesia) and 9 AD patients without EPS, comparable in age, duration of illness, and global cognitive decline, were studied with [99mTc]HMPAO SPECT. Patients with AD and EPS showed significantly lower rCBF in the superior frontal, superior temporal, and parietal regions of the left hemisphere than AD patients without EPS. Rigidity and bradykinesia independently accounted for the decreased rCBF in these areas. These findings suggest that the presence of EPS in AD may result from dysfunction in specific brain regions. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_08950172_v7_n3_p308_Starkstein |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
hexamethylpropylene amine oxime technetium tc 99m aged Alzheimer disease article bradykinesia brain blood flow clinical article cognitive defect extrapyramidal symptom female frontal lobe human left hemisphere male parietal lobe parkinsonism priority journal rigidity single photon emission computer tomography temporal lobe tremor |
| spellingShingle |
hexamethylpropylene amine oxime technetium tc 99m aged Alzheimer disease article bradykinesia brain blood flow clinical article cognitive defect extrapyramidal symptom female frontal lobe human left hemisphere male parietal lobe parkinsonism priority journal rigidity single photon emission computer tomography temporal lobe tremor Starkstein, S.E. Vazquez, S. Merello, M. Teson, A. Petracchi, M. Leiguarda, R. A SPECT study of Parkinsonism in Alzheimer's disease |
| topic_facet |
hexamethylpropylene amine oxime technetium tc 99m aged Alzheimer disease article bradykinesia brain blood flow clinical article cognitive defect extrapyramidal symptom female frontal lobe human left hemisphere male parietal lobe parkinsonism priority journal rigidity single photon emission computer tomography temporal lobe tremor |
| description |
The authors examined the presence of significant regional cerebral blood flow (rCBF) differences between Alzheimer's disease (AD) patients with and without extrapyramidal signs (EPS). Nine patients with probable AD and EPS (resting tremor or rigidity and bradykinesia) and 9 AD patients without EPS, comparable in age, duration of illness, and global cognitive decline, were studied with [99mTc]HMPAO SPECT. Patients with AD and EPS showed significantly lower rCBF in the superior frontal, superior temporal, and parietal regions of the left hemisphere than AD patients without EPS. Rigidity and bradykinesia independently accounted for the decreased rCBF in these areas. These findings suggest that the presence of EPS in AD may result from dysfunction in specific brain regions. |
| format |
JOUR |
| author |
Starkstein, S.E. Vazquez, S. Merello, M. Teson, A. Petracchi, M. Leiguarda, R. |
| author_facet |
Starkstein, S.E. Vazquez, S. Merello, M. Teson, A. Petracchi, M. Leiguarda, R. |
| author_sort |
Starkstein, S.E. |
| title |
A SPECT study of Parkinsonism in Alzheimer's disease |
| title_short |
A SPECT study of Parkinsonism in Alzheimer's disease |
| title_full |
A SPECT study of Parkinsonism in Alzheimer's disease |
| title_fullStr |
A SPECT study of Parkinsonism in Alzheimer's disease |
| title_full_unstemmed |
A SPECT study of Parkinsonism in Alzheimer's disease |
| title_sort |
spect study of parkinsonism in alzheimer's disease |
| url |
http://hdl.handle.net/20.500.12110/paper_08950172_v7_n3_p308_Starkstein |
| work_keys_str_mv |
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