Anosognosia and procedural learning in Alzheimer's disease
Awareness of cognitive deficits may rely on the implicit learning of intellectual limitations, and anosognosia in Alzheimer's disease (AD) may result from deficits in implicit learning. To examine this hypothesis, a consecutive series of 55 patients with probable AD were divided into groups wit...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0894878X_v10_n2_p96_Starkstein |
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todo:paper_0894878X_v10_n2_p96_Starkstein2023-10-03T15:42:17Z Anosognosia and procedural learning in Alzheimer's disease Starkstein, S.E. Sabe, L. Cuerva, A.G. Kuzis, G. Leiguarda, R. Alzheimer's disease Anosognosia Learning Memory adult aged alzheimer disease anosognosia article awareness cognitive defect controlled study disease severity habit human learning major clinical study maze test neuropsychological test performance priority journal Aged Aged, 80 and over Agnosia Alzheimer Disease Attention Awareness Discrimination Learning Female Frontal Lobe Humans Male Maze Learning Mental Recall Middle Aged Neuropsychological Tests Problem Solving Retention (Psychology) Awareness of cognitive deficits may rely on the implicit learning of intellectual limitations, and anosognosia in Alzheimer's disease (AD) may result from deficits in implicit learning. To examine this hypothesis, a consecutive series of 55 patients with probable AD were divided into groups with mild (n = 13), severe (n = 12), or no anosognosia (n = 30) and were assessed with a neuropsychological battery that included tests of declarative and procedural learning. Whereas there were no significant between-group differences in tests of declarative learning (the Buschke Selective Reminding Test and the Benton Visual Retention Test), patients with severe anosognosia showed a significantly worse performance on procedural learning (as measured with the Maze Learning Test) and a test assessing set shifting abilities (the Wisconsin Card Sorting Test) than AD patients without anosognosia. The authors' results suggest that deficits in procedural learning and anosognosia in AD may result from dysfunction in habit-learning systems. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0894878X_v10_n2_p96_Starkstein |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Alzheimer's disease Anosognosia Learning Memory adult aged alzheimer disease anosognosia article awareness cognitive defect controlled study disease severity habit human learning major clinical study maze test neuropsychological test performance priority journal Aged Aged, 80 and over Agnosia Alzheimer Disease Attention Awareness Discrimination Learning Female Frontal Lobe Humans Male Maze Learning Mental Recall Middle Aged Neuropsychological Tests Problem Solving Retention (Psychology) |
| spellingShingle |
Alzheimer's disease Anosognosia Learning Memory adult aged alzheimer disease anosognosia article awareness cognitive defect controlled study disease severity habit human learning major clinical study maze test neuropsychological test performance priority journal Aged Aged, 80 and over Agnosia Alzheimer Disease Attention Awareness Discrimination Learning Female Frontal Lobe Humans Male Maze Learning Mental Recall Middle Aged Neuropsychological Tests Problem Solving Retention (Psychology) Starkstein, S.E. Sabe, L. Cuerva, A.G. Kuzis, G. Leiguarda, R. Anosognosia and procedural learning in Alzheimer's disease |
| topic_facet |
Alzheimer's disease Anosognosia Learning Memory adult aged alzheimer disease anosognosia article awareness cognitive defect controlled study disease severity habit human learning major clinical study maze test neuropsychological test performance priority journal Aged Aged, 80 and over Agnosia Alzheimer Disease Attention Awareness Discrimination Learning Female Frontal Lobe Humans Male Maze Learning Mental Recall Middle Aged Neuropsychological Tests Problem Solving Retention (Psychology) |
| description |
Awareness of cognitive deficits may rely on the implicit learning of intellectual limitations, and anosognosia in Alzheimer's disease (AD) may result from deficits in implicit learning. To examine this hypothesis, a consecutive series of 55 patients with probable AD were divided into groups with mild (n = 13), severe (n = 12), or no anosognosia (n = 30) and were assessed with a neuropsychological battery that included tests of declarative and procedural learning. Whereas there were no significant between-group differences in tests of declarative learning (the Buschke Selective Reminding Test and the Benton Visual Retention Test), patients with severe anosognosia showed a significantly worse performance on procedural learning (as measured with the Maze Learning Test) and a test assessing set shifting abilities (the Wisconsin Card Sorting Test) than AD patients without anosognosia. The authors' results suggest that deficits in procedural learning and anosognosia in AD may result from dysfunction in habit-learning systems. |
| format |
JOUR |
| author |
Starkstein, S.E. Sabe, L. Cuerva, A.G. Kuzis, G. Leiguarda, R. |
| author_facet |
Starkstein, S.E. Sabe, L. Cuerva, A.G. Kuzis, G. Leiguarda, R. |
| author_sort |
Starkstein, S.E. |
| title |
Anosognosia and procedural learning in Alzheimer's disease |
| title_short |
Anosognosia and procedural learning in Alzheimer's disease |
| title_full |
Anosognosia and procedural learning in Alzheimer's disease |
| title_fullStr |
Anosognosia and procedural learning in Alzheimer's disease |
| title_full_unstemmed |
Anosognosia and procedural learning in Alzheimer's disease |
| title_sort |
anosognosia and procedural learning in alzheimer's disease |
| url |
http://hdl.handle.net/20.500.12110/paper_0894878X_v10_n2_p96_Starkstein |
| work_keys_str_mv |
AT starksteinse anosognosiaandprocedurallearninginalzheimersdisease AT sabel anosognosiaandprocedurallearninginalzheimersdisease AT cuervaag anosognosiaandprocedurallearninginalzheimersdisease AT kuzisg anosognosiaandprocedurallearninginalzheimersdisease AT leiguardar anosognosiaandprocedurallearninginalzheimersdisease |
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