Synergistic Antiproliferative Effects of a New Cucurbitacin B Derivative and Chemotherapy Drugs on Lung Cancer Cell Line A549

Nonsmall cell lung cancer (NSCLC) represents an important cause of mortality worldwide due to its aggressiveness and growing resistance to currently available therapy. Cucurbitacins have emerged as novel potential anticancer agents showing strong antiproliferative effects and can be promising candid...

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Autores principales:	Marostica, L.L., Silva, I.T., Kratz, J.M., Persich, L., Geller, F.C., Lang, K.L., Caro, M.S.B., Durán, F.J., Schenkel, E.P., Simões, C.M.O.
Formato:	JOUR
Materias:	2 deoxy 2 amine cucurbitacin E acetylcysteine buthionine sulfoximine caspase cisplatin cucurbitacin F actin irinotecan paclitaxel protein p53 reactive oxygen metabolite survivin unclassified drug actin antineoplastic agent BIRC5 protein, human camptothecin cucurbitacin B inhibitor of apoptosis protein TP53 protein, human triterpene A549 cell line antiproliferative activity apoptosis Article cancer inhibition cell proliferation comparative effectiveness computer model controlled study cytoskeleton drug mechanism drug potency drug potentiation drug structure enzyme activity enzyme inhibition flow cytometry G2 phase cell cycle checkpoint human human cell IC50 metastasis inhibition migration inhibition protein expression analogs and derivatives cell motion chemistry drug effects Lung Neoplasms M phase cell cycle checkpoint metabolism pathology tumor cell line Actins Antineoplastic Agents Apoptosis Camptothecin Cell Line, Tumor Cell Movement Cell Proliferation Cisplatin Drug Synergism G2 Phase Cell Cycle Checkpoints Humans Inhibitor of Apoptosis Proteins M Phase Cell Cycle Checkpoints Paclitaxel Reactive Oxygen Species Triterpenes Tumor Suppressor Protein p53
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0893228X_v28_n10_p1949_Marostica
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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