Molecular basis of the mechanism of thiol oxidation by hydrogen peroxide in aqueous solution: Challenging the S N2 paradigm

The oxidation of cellular thiol-containing compounds, such as glutathione and protein Cys residues, is considered to play an important role in many biological processes. Among possible oxidants, hydrogen peroxide (H 2O 2) is known to be produced in many cell types as a response to a variety of extra...

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Detalles Bibliográficos
Autores principales:	Zeida, A., Babbush, R., González Lebrero, M.C., Trujillo, M., Radi, R., Estrin, D.A.
Formato:	JOUR
Materias:	hydrogen peroxide hydroxyl group methanethiol oxygen sulfenic acid derivative sulfur thiol transition element water aqueous solution article chemical reaction electrophilicity molecular dynamics oxidation Hydrogen Peroxide Molecular Dynamics Simulation Oxidation-Reduction Sulfhydryl Compounds
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0893228X_v25_n3_p741_Zeida
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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