The fibronectin gene as a model for splicing and transcription studies
The fibronectin (FN) gene has become paradigmatic to illustrate genome evolution by exon shuffling, generation of protein diversity by alternative mRNA splicing, and topological coordination between transcription and splicing. Alternative splicing in three sites of the primary transcript gives rise...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_08926638_v10_n2_p248_Kornblihtt |
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todo:paper_08926638_v10_n2_p248_Kornblihtt2023-10-03T15:41:32Z The fibronectin gene as a model for splicing and transcription studies Kornblihtt, A.R. Pesce, C.G. Alonso, C.R. Cramer, P. Srebrow, A. Werbajh, S. Muro, A.F. alternative splicing cell binding extra domain I transcriptional regulation cyclic amp fibronectin growth factor transcription factor alternative rna splicing cell maturation cell type down regulation evolution exon genetic transcription genome oncogene priority journal promoter region protein structure review rna processing rna sequence rna splicing transcription regulation virus transformation Alternative Splicing Animals Fibronectins Humans Oncogenes Promoter Regions (Genetics) Transcription, Genetic The fibronectin (FN) gene has become paradigmatic to illustrate genome evolution by exon shuffling, generation of protein diversity by alternative mRNA splicing, and topological coordination between transcription and splicing. Alternative splicing in three sites of the primary transcript gives rise to multiple FN polypeptides. This process is cell type-, development- and age-regulated. The different FN variants seem to play specific roles in FN dimer secretion, blood clotting, adhesion to lymphoid cells, skin wound healing, atherosclerosis, and liver fibrosis. This review focuses on function assignment to the alternatively spliced segments, as well as on the external signals and cis-acting sequences that control the mechanisms of alternative splicing. We also discuss FN transcriptional regulation in response to viral transformation, growth factors, and cyclic AMP in the light of promoter architecture and its interaction with specific transcription factors. The relevance of FN RNA 'tracks' as assembly lines of coordinated transcription and RNA processing is also addressed. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_08926638_v10_n2_p248_Kornblihtt |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
alternative splicing cell binding extra domain I transcriptional regulation cyclic amp fibronectin growth factor transcription factor alternative rna splicing cell maturation cell type down regulation evolution exon genetic transcription genome oncogene priority journal promoter region protein structure review rna processing rna sequence rna splicing transcription regulation virus transformation Alternative Splicing Animals Fibronectins Humans Oncogenes Promoter Regions (Genetics) Transcription, Genetic |
| spellingShingle |
alternative splicing cell binding extra domain I transcriptional regulation cyclic amp fibronectin growth factor transcription factor alternative rna splicing cell maturation cell type down regulation evolution exon genetic transcription genome oncogene priority journal promoter region protein structure review rna processing rna sequence rna splicing transcription regulation virus transformation Alternative Splicing Animals Fibronectins Humans Oncogenes Promoter Regions (Genetics) Transcription, Genetic Kornblihtt, A.R. Pesce, C.G. Alonso, C.R. Cramer, P. Srebrow, A. Werbajh, S. Muro, A.F. The fibronectin gene as a model for splicing and transcription studies |
| topic_facet |
alternative splicing cell binding extra domain I transcriptional regulation cyclic amp fibronectin growth factor transcription factor alternative rna splicing cell maturation cell type down regulation evolution exon genetic transcription genome oncogene priority journal promoter region protein structure review rna processing rna sequence rna splicing transcription regulation virus transformation Alternative Splicing Animals Fibronectins Humans Oncogenes Promoter Regions (Genetics) Transcription, Genetic |
| description |
The fibronectin (FN) gene has become paradigmatic to illustrate genome evolution by exon shuffling, generation of protein diversity by alternative mRNA splicing, and topological coordination between transcription and splicing. Alternative splicing in three sites of the primary transcript gives rise to multiple FN polypeptides. This process is cell type-, development- and age-regulated. The different FN variants seem to play specific roles in FN dimer secretion, blood clotting, adhesion to lymphoid cells, skin wound healing, atherosclerosis, and liver fibrosis. This review focuses on function assignment to the alternatively spliced segments, as well as on the external signals and cis-acting sequences that control the mechanisms of alternative splicing. We also discuss FN transcriptional regulation in response to viral transformation, growth factors, and cyclic AMP in the light of promoter architecture and its interaction with specific transcription factors. The relevance of FN RNA 'tracks' as assembly lines of coordinated transcription and RNA processing is also addressed. |
| format |
JOUR |
| author |
Kornblihtt, A.R. Pesce, C.G. Alonso, C.R. Cramer, P. Srebrow, A. Werbajh, S. Muro, A.F. |
| author_facet |
Kornblihtt, A.R. Pesce, C.G. Alonso, C.R. Cramer, P. Srebrow, A. Werbajh, S. Muro, A.F. |
| author_sort |
Kornblihtt, A.R. |
| title |
The fibronectin gene as a model for splicing and transcription studies |
| title_short |
The fibronectin gene as a model for splicing and transcription studies |
| title_full |
The fibronectin gene as a model for splicing and transcription studies |
| title_fullStr |
The fibronectin gene as a model for splicing and transcription studies |
| title_full_unstemmed |
The fibronectin gene as a model for splicing and transcription studies |
| title_sort |
fibronectin gene as a model for splicing and transcription studies |
| url |
http://hdl.handle.net/20.500.12110/paper_08926638_v10_n2_p248_Kornblihtt |
| work_keys_str_mv |
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