Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations
Experience-dependent plasticity during critical periods of postnatal (PN) development shapes the adult brain anatomy and function. In rat motor system, there is a critical period of activity-dependent plasticity in the striatum (PN30-37). In this period, motor activity of running in a circular path...
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todo:paper_08920362_v31_n4_p191_SoizaReilly2023-10-03T15:41:29Z Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations Soiza-Reilly, M. Azcurra, J.M. Critical period Haloperidol Motor behavior Plasticity Postnatal development Striatum dopamine 2 receptor haloperidol animal experiment article behavior disorder binding site brain development controlled study corpus striatum disease predisposition instrumental conditioning locomotion male motor performance nerve cell plasticity nonhuman open field test postnatal development priority journal protein expression rat Age Factors Animals Antipsychotic Agents Binding Sites Brain Chemistry Corpus Striatum Dopamine Dopamine Antagonists Dyskinesia, Drug-Induced Haloperidol Male Motor Activity Neuronal Plasticity Rats Rats, Sprague-Dawley Receptors, Dopamine D2 RNA, Messenger Time Animalia Rattus Experience-dependent plasticity during critical periods of postnatal (PN) development shapes the adult brain anatomy and function. In rat motor system, there is a critical period of activity-dependent plasticity in the striatum (PN30-37). In this period, motor activity of running in a circular path induced in the Circling Training test (CT), elicits several plasticity changes on striatal synapses. It has been recently proposed that developmental critical periods might represent a unique pharmacological window of vulnerability to induce life-lasting behavioral modifications. In this paper we tested the hypothesis of existence of a pharmacological susceptibility to induce adult alterations on motor behavior during the striatal critical period. Due to its main action on the striatum and developmental motor behavioral effects, we applied the prototypical antipsychotic haloperidol to male rats (i.p. 0.7 or 2.5 mg/kg/day) before, during or after the period of plasticity (PN20-27, PN30-37 or PN40-47 respectively). Then, in the adulthood (PN80), we evaluated induced motor activity in the CT. The results showed that only rats exposed to the D2R blocker during the period PN30-37 increased the CT activity in comparison to control rats. Moreover, only these animals also showed an increase in the spontaneous locomotor activity at the open field test. These behavioral alterations were not accompanied by permanent striatal changes either on the number of D2R binding sites or on its mRNA expression levels. In conclusion, we have shown a pharmacological susceptibility of inducing adult motor behavior alterations by haloperidol during a natural critical period of activity-dependent plasticity (PN30-37) in rat striatum development. These results also emphasize the importance of behavioral screening for pharmacological agents to be used in developmental stages of maturation. © 2009 Elsevier Inc. All rights reserved. Fil:Soiza-Reilly, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Azcurra, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_08920362_v31_n4_p191_SoizaReilly |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Critical period Haloperidol Motor behavior Plasticity Postnatal development Striatum dopamine 2 receptor haloperidol animal experiment article behavior disorder binding site brain development controlled study corpus striatum disease predisposition instrumental conditioning locomotion male motor performance nerve cell plasticity nonhuman open field test postnatal development priority journal protein expression rat Age Factors Animals Antipsychotic Agents Binding Sites Brain Chemistry Corpus Striatum Dopamine Dopamine Antagonists Dyskinesia, Drug-Induced Haloperidol Male Motor Activity Neuronal Plasticity Rats Rats, Sprague-Dawley Receptors, Dopamine D2 RNA, Messenger Time Animalia Rattus |
| spellingShingle |
Critical period Haloperidol Motor behavior Plasticity Postnatal development Striatum dopamine 2 receptor haloperidol animal experiment article behavior disorder binding site brain development controlled study corpus striatum disease predisposition instrumental conditioning locomotion male motor performance nerve cell plasticity nonhuman open field test postnatal development priority journal protein expression rat Age Factors Animals Antipsychotic Agents Binding Sites Brain Chemistry Corpus Striatum Dopamine Dopamine Antagonists Dyskinesia, Drug-Induced Haloperidol Male Motor Activity Neuronal Plasticity Rats Rats, Sprague-Dawley Receptors, Dopamine D2 RNA, Messenger Time Animalia Rattus Soiza-Reilly, M. Azcurra, J.M. Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations |
| topic_facet |
Critical period Haloperidol Motor behavior Plasticity Postnatal development Striatum dopamine 2 receptor haloperidol animal experiment article behavior disorder binding site brain development controlled study corpus striatum disease predisposition instrumental conditioning locomotion male motor performance nerve cell plasticity nonhuman open field test postnatal development priority journal protein expression rat Age Factors Animals Antipsychotic Agents Binding Sites Brain Chemistry Corpus Striatum Dopamine Dopamine Antagonists Dyskinesia, Drug-Induced Haloperidol Male Motor Activity Neuronal Plasticity Rats Rats, Sprague-Dawley Receptors, Dopamine D2 RNA, Messenger Time Animalia Rattus |
| description |
Experience-dependent plasticity during critical periods of postnatal (PN) development shapes the adult brain anatomy and function. In rat motor system, there is a critical period of activity-dependent plasticity in the striatum (PN30-37). In this period, motor activity of running in a circular path induced in the Circling Training test (CT), elicits several plasticity changes on striatal synapses. It has been recently proposed that developmental critical periods might represent a unique pharmacological window of vulnerability to induce life-lasting behavioral modifications. In this paper we tested the hypothesis of existence of a pharmacological susceptibility to induce adult alterations on motor behavior during the striatal critical period. Due to its main action on the striatum and developmental motor behavioral effects, we applied the prototypical antipsychotic haloperidol to male rats (i.p. 0.7 or 2.5 mg/kg/day) before, during or after the period of plasticity (PN20-27, PN30-37 or PN40-47 respectively). Then, in the adulthood (PN80), we evaluated induced motor activity in the CT. The results showed that only rats exposed to the D2R blocker during the period PN30-37 increased the CT activity in comparison to control rats. Moreover, only these animals also showed an increase in the spontaneous locomotor activity at the open field test. These behavioral alterations were not accompanied by permanent striatal changes either on the number of D2R binding sites or on its mRNA expression levels. In conclusion, we have shown a pharmacological susceptibility of inducing adult motor behavior alterations by haloperidol during a natural critical period of activity-dependent plasticity (PN30-37) in rat striatum development. These results also emphasize the importance of behavioral screening for pharmacological agents to be used in developmental stages of maturation. © 2009 Elsevier Inc. All rights reserved. |
| format |
JOUR |
| author |
Soiza-Reilly, M. Azcurra, J.M. |
| author_facet |
Soiza-Reilly, M. Azcurra, J.M. |
| author_sort |
Soiza-Reilly, M. |
| title |
Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations |
| title_short |
Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations |
| title_full |
Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations |
| title_fullStr |
Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations |
| title_full_unstemmed |
Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations |
| title_sort |
developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations |
| url |
http://hdl.handle.net/20.500.12110/paper_08920362_v31_n4_p191_SoizaReilly |
| work_keys_str_mv |
AT soizareillym developmentalstriatalcriticalperiodofactivitydependentplasticityisalsoawindowofsusceptibilityforhaloperidolinducedadultmotoralterations AT azcurrajm developmentalstriatalcriticalperiodofactivitydependentplasticityisalsoawindowofsusceptibilityforhaloperidolinducedadultmotoralterations |
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