Transcriptional regulation of pituitary POMC is conserved at the vertebrate extremes despite great promoter sequence divergence

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The stress response involves complex physiological mechanisms that maximize behavioral efficacy during attack or defense and is highly conserved in all vertebrates. Key mediators of the stress response are pituitary hormones encoded by the proopiomelanocortin gene (POMC). Despite conservation of phy...

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Detalles Bibliográficos
Autores principales: Bumaschny, V.F., De Souza, F.S.J., Leal, R.A.L., Santangelo, A.M., Baetscher, M., Levi, D.H., Low, M.J., Rubinstein, M.
Formato: JOUR
Materias:
cell nucleus receptor
proopiomelanocortin
adrenalectomy
animal experiment
animal tissue
article
controlled study
corticotropin release
DNA flanking region
DNA sequence
female
gene
gene deletion
gene locus
gene sequence
genetic conservation
genetic variability
hormonal regulation
molecular phylogeny
mouse
nonhuman
orthology
priority journal
promoter region
proopiomelanocortin gene
protein motif
reporter gene
sequence alignment
sequence analysis
teleost
transcription regulation
transgenic mouse
Amino Acid Motifs
Animals
CHO Cells
Cricetinae
Cricetulus
Fishes
Gene Expression Regulation
Mice
Mice, Transgenic
Phylogeny
Pituitary Gland
Pro-Opiomelanocortin
Promoter Regions (Genetics)
Species Specificity
Transcription, Genetic
Mammalia
Mus musculus
Teleostei
Tetraodon
Tetraodon nigroviridis
Vertebrata
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_08888809_v21_n11_p2738_Bumaschny
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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