Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1

Immune evasion strategies are important for the onset and the maintenance of viral infections. Many viruses have evolved mechanisms to counteract or suppress the host immune response. We have previously characterized two syncytial (syn) variants of Herpes simplex 1 (HSV-1) strain F, syn14-1 and syn1...

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Autores principales:	Carolina Artuso, M., Linero, F.N., Gazzaniga, S., Scolaro, L.A., Pujol, C.A., Wainstok, R., Carlucci, M.J.
Formato:	JOUR
Materias:	Cytokines Herpes Mouse Pathology Virulence carrageenan cytokine glycoprotein D interleukin 6 tumor necrosis factor alpha glycoprotein D, Human herpesvirus 1 virus envelope protein animal cell animal experiment animal model animal tissue article controlled study cytokine release female gene sequence Herpes simplex virus 1 Herpes simplex virus 1 (syn14-1 variant) Herpes simplex virus 1 (syn17-21 variant) immune response immunocompetent cell lung alveolus macrophage lung infection lung parenchyma mouse nonhuman point mutation priority journal protein expression virus replication virus strain animal Bagg albino mouse genetics immunology mucosa pathology respiratory tract infection secretion (process) virology Animalia Human herpesvirus 1 Mus Animals Female Herpesvirus 1, Human Mice Mice, Inbred BALB C Mucous Membrane Point Mutation Respiratory Tract Infections Viral Envelope Proteins
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_08824010_v71-72_n1_p68_CarolinaArtuso
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_08824010_v71-72_n1_p68_CarolinaArtuso
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spelling	todo:paper_08824010_v71-72_n1_p68_CarolinaArtuso2023-10-03T15:40:22Z Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1 Carolina Artuso, M. Linero, F.N. Gazzaniga, S. Scolaro, L.A. Pujol, C.A. Wainstok, R. Carlucci, M.J. Cytokines Herpes Mouse Pathology Virulence carrageenan cytokine glycoprotein D interleukin 6 tumor necrosis factor alpha cytokine glycoprotein D, Human herpesvirus 1 virus envelope protein animal cell animal experiment animal model animal tissue article controlled study cytokine release female gene sequence Herpes simplex virus 1 Herpes simplex virus 1 (syn14-1 variant) Herpes simplex virus 1 (syn17-21 variant) immune response immunocompetent cell lung alveolus macrophage lung infection lung parenchyma mouse nonhuman point mutation priority journal protein expression virus replication virus strain animal Bagg albino mouse genetics Herpes simplex virus 1 immunology mucosa pathology respiratory tract infection secretion (process) virology Animalia Herpes Human herpesvirus 1 Mus Animals Cytokines Female Herpesvirus 1, Human Mice Mice, Inbred BALB C Mucous Membrane Point Mutation Respiratory Tract Infections Viral Envelope Proteins Immune evasion strategies are important for the onset and the maintenance of viral infections. Many viruses have evolved mechanisms to counteract or suppress the host immune response. We have previously characterized two syncytial (syn) variants of Herpes simplex 1 (HSV-1) strain F, syn14-1 and syn17-2, obtained by selective pressure with a natural carrageenan. These variants showed a differential pathology in vaginal and respiratory mucosa infection in comparison with parental strain. In this paper, we evaluated the modulation of immune response in respiratory mucosa by these HSV-1 variants. We observed altered levels of Tumor Necrosis Factor-α and Interleukin-6 in lungs of animals infected with the syn14-1 and syn17-2 variants compared with the parental strain. Also, we detected differences in the recruitment of immune cells to the lung in syn variants infected mice. Both variants exhibit one point mutation in the sequence of the gene of glycoprotein D detected in the ectodomain of syn14-1 and the cytoplasmic tail of syn17-2. Results obtained in the present study contribute to the characterization of HSV-1 syn variants and the participation of the cellular inflammatory response in viral pathogenesis. © 2014 Elsevier Ltd. Fil:Linero, F.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gazzaniga, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Scolaro, L.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pujol, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Carlucci, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_08824010_v71-72_n1_p68_CarolinaArtuso
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cytokines Herpes Mouse Pathology Virulence carrageenan cytokine glycoprotein D interleukin 6 tumor necrosis factor alpha cytokine glycoprotein D, Human herpesvirus 1 virus envelope protein animal cell animal experiment animal model animal tissue article controlled study cytokine release female gene sequence Herpes simplex virus 1 Herpes simplex virus 1 (syn14-1 variant) Herpes simplex virus 1 (syn17-21 variant) immune response immunocompetent cell lung alveolus macrophage lung infection lung parenchyma mouse nonhuman point mutation priority journal protein expression virus replication virus strain animal Bagg albino mouse genetics Herpes simplex virus 1 immunology mucosa pathology respiratory tract infection secretion (process) virology Animalia Herpes Human herpesvirus 1 Mus Animals Cytokines Female Herpesvirus 1, Human Mice Mice, Inbred BALB C Mucous Membrane Point Mutation Respiratory Tract Infections Viral Envelope Proteins
spellingShingle	Cytokines Herpes Mouse Pathology Virulence carrageenan cytokine glycoprotein D interleukin 6 tumor necrosis factor alpha cytokine glycoprotein D, Human herpesvirus 1 virus envelope protein animal cell animal experiment animal model animal tissue article controlled study cytokine release female gene sequence Herpes simplex virus 1 Herpes simplex virus 1 (syn14-1 variant) Herpes simplex virus 1 (syn17-21 variant) immune response immunocompetent cell lung alveolus macrophage lung infection lung parenchyma mouse nonhuman point mutation priority journal protein expression virus replication virus strain animal Bagg albino mouse genetics Herpes simplex virus 1 immunology mucosa pathology respiratory tract infection secretion (process) virology Animalia Herpes Human herpesvirus 1 Mus Animals Cytokines Female Herpesvirus 1, Human Mice Mice, Inbred BALB C Mucous Membrane Point Mutation Respiratory Tract Infections Viral Envelope Proteins Carolina Artuso, M. Linero, F.N. Gazzaniga, S. Scolaro, L.A. Pujol, C.A. Wainstok, R. Carlucci, M.J. Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1
topic_facet	Cytokines Herpes Mouse Pathology Virulence carrageenan cytokine glycoprotein D interleukin 6 tumor necrosis factor alpha cytokine glycoprotein D, Human herpesvirus 1 virus envelope protein animal cell animal experiment animal model animal tissue article controlled study cytokine release female gene sequence Herpes simplex virus 1 Herpes simplex virus 1 (syn14-1 variant) Herpes simplex virus 1 (syn17-21 variant) immune response immunocompetent cell lung alveolus macrophage lung infection lung parenchyma mouse nonhuman point mutation priority journal protein expression virus replication virus strain animal Bagg albino mouse genetics Herpes simplex virus 1 immunology mucosa pathology respiratory tract infection secretion (process) virology Animalia Herpes Human herpesvirus 1 Mus Animals Cytokines Female Herpesvirus 1, Human Mice Mice, Inbred BALB C Mucous Membrane Point Mutation Respiratory Tract Infections Viral Envelope Proteins
description	Immune evasion strategies are important for the onset and the maintenance of viral infections. Many viruses have evolved mechanisms to counteract or suppress the host immune response. We have previously characterized two syncytial (syn) variants of Herpes simplex 1 (HSV-1) strain F, syn14-1 and syn17-2, obtained by selective pressure with a natural carrageenan. These variants showed a differential pathology in vaginal and respiratory mucosa infection in comparison with parental strain. In this paper, we evaluated the modulation of immune response in respiratory mucosa by these HSV-1 variants. We observed altered levels of Tumor Necrosis Factor-α and Interleukin-6 in lungs of animals infected with the syn14-1 and syn17-2 variants compared with the parental strain. Also, we detected differences in the recruitment of immune cells to the lung in syn variants infected mice. Both variants exhibit one point mutation in the sequence of the gene of glycoprotein D detected in the ectodomain of syn14-1 and the cytoplasmic tail of syn17-2. Results obtained in the present study contribute to the characterization of HSV-1 syn variants and the participation of the cellular inflammatory response in viral pathogenesis. © 2014 Elsevier Ltd.
format	JOUR
author	Carolina Artuso, M. Linero, F.N. Gazzaniga, S. Scolaro, L.A. Pujol, C.A. Wainstok, R. Carlucci, M.J.
author_facet	Carolina Artuso, M. Linero, F.N. Gazzaniga, S. Scolaro, L.A. Pujol, C.A. Wainstok, R. Carlucci, M.J.
author_sort	Carolina Artuso, M.
title	Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1
title_short	Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1
title_full	Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1
title_fullStr	Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1
title_full_unstemmed	Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1
title_sort	altered expression of cytokines in mice infected intranasally with two syncytial variants of herpes simplex virus type 1
url	http://hdl.handle.net/20.500.12110/paper_08824010_v71-72_n1_p68_CarolinaArtuso
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_version_	1782026848347095040

Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1

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