Pleiotropic effects of 5-aminolevulinic acid in mouse brain

5-Aminolevulinic acid (ALA) seems to be responsible for the neuropsychiatric manifestations of acute intermittent porphyria (AIP). Our aim was to study the effect of ALA on the different metabolic pathways in the mouse brain to enhance our knowledge about the action of this heme precursor on the cen...

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Detalles Bibliográficos
Autores principales:	Lavandera, J., Rodríguez, J., Ruspini, S., Meiss, R., Zuccoli, J.R., Martínez, M.D.C., Gerez, E., Batlle, A., Buzaleh, A.M.
Formato:	JOUR
Materias:	5-aminolevulinic acid Antioxidant defense system Cholinergic system Heme metabolism Nitric oxide synthase Antioxidants Enzymes Metabolism Nitric oxide Oxygen Physiology Porphyrins Anti-oxidant response Central nervous systems Cholinergic systems Nitric-oxide synthase Pleiotropic effects Superoxide dismutase activities Mammals aminolevulinic acid cholinesterase heme oxygenase malonaldehyde nitric oxide synthase superoxide dismutase acetylcholinesterase antioxidant heme photosensitizing agent acute intermittent porphyria animal experiment animal model animal tissue Article brain brain homogenate brain metabolism cholinergic system controlled study enzyme activity glia cell immunohistochemistry long term care male morning dosage mouse nonhuman oxidative stress pleiotropy single drug dose treatment duration Western blotting animal drug effects metabolism pathology Acetylcholinesterase Aminolevulinic Acid Animals Brain Heme Male Mice Nitric Oxide Synthase Oxidative Stress Photosensitizing Agents
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_08298211_v94_n4_p297_Lavandera
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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