Cortisol: A tool to study aldosterone biosynthesis in rats

Corticosterone (B) and 18-hydroxy-11-deoxycorticosterone (18OHDOC) but not 11-deoxycorticosterone (DOC) displaced cortisol (F) specifically bound to rat adrenal mitochondria. F competitively inhibited aldosterone formation from B, 18OHB and 18OHDOC but did not inhibit conversions of DOC to B or 18OH...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Matkovic, L., Gomez-sanchez, C.E., Lantos, C.P., Cozza, E.N.
Formato: JOUR
Materias:
18 hydroxydeoxycorticosterone
aldosterone
corticosterone
cytochrome p450
deoxycorticosterone
hydrocortisone
steroid 11beta monooxygenase
adrenal cortex
animal tissue
conference paper
controlled study
enzyme activity
enzyme substrate
male
mitochondrion
nonhuman
priority journal
rat
steroidogenesis
18-Hydroxydesoxycorticosterone
Adrenal Glands
Aldosterone
Animal
Binding, Competitive
Corticosterone
Hydrocortisone
Male
Mitochondria
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_07435800_v21_n1-2_p471_Matkovic
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Corticosterone (B) and 18-hydroxy-11-deoxycorticosterone (18OHDOC) but not 11-deoxycorticosterone (DOC) displaced cortisol (F) specifically bound to rat adrenal mitochondria. F competitively inhibited aldosterone formation from B, 18OHB and 18OHDOC but did not inhibit conversions of DOC to B or 18OHDOC. High concentrations of DOC increased its conversion to 18OHDOC rather than B. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Ejemplares similares