Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs
Rat pups were treated with monoamine uptake inhibiting antidepressant drugs, desipramine, imipramine or nomifensine (5 mg/kg) during the second and third postnatal weeks, and their later behavioral "despair," measured by Porsolt's swim test, was examined. At the age of two months, the...
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todo:paper_07418329_v6_n2_p93_FernandezPardal2023-10-03T15:38:21Z Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs Fernandez-Pardal, J. Hilakivi, L.A. Alcohol Behavioral "despair" Desipramine Imipramine Neonatal Nomifensine alcohol desipramine imipramine nomifensine animal experiment behavior intraperitoneal drug administration male newborn nonhuman psychological aspect rat Animal Animals, Newborn Antidepressive Agents Depression Desipramine Ethanol Imipramine Male Motor Activity Nomifensine Rats Rats, Inbred Strains Rat pups were treated with monoamine uptake inhibiting antidepressant drugs, desipramine, imipramine or nomifensine (5 mg/kg) during the second and third postnatal weeks, and their later behavioral "despair," measured by Porsolt's swim test, was examined. At the age of two months, the desipramine-treated rats showed lengthened immobility in the swim test, and thus probably increased behavioral "despair." They also responded to 1 g/kg alcohol by shortening the immobility to the level of control rats. Neonatal treatment with either imipramine or nomifensine did not affect the swim test behavior. The results suggest that a low, stimulatory dose of alcohol was able to reverse the lengthened immobility in the swim test of rats treated with desipramine during the early postnatal period. © 1989. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_07418329_v6_n2_p93_FernandezPardal |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Alcohol Behavioral "despair" Desipramine Imipramine Neonatal Nomifensine alcohol desipramine imipramine nomifensine animal experiment behavior intraperitoneal drug administration male newborn nonhuman psychological aspect rat Animal Animals, Newborn Antidepressive Agents Depression Desipramine Ethanol Imipramine Male Motor Activity Nomifensine Rats Rats, Inbred Strains |
| spellingShingle |
Alcohol Behavioral "despair" Desipramine Imipramine Neonatal Nomifensine alcohol desipramine imipramine nomifensine animal experiment behavior intraperitoneal drug administration male newborn nonhuman psychological aspect rat Animal Animals, Newborn Antidepressive Agents Depression Desipramine Ethanol Imipramine Male Motor Activity Nomifensine Rats Rats, Inbred Strains Fernandez-Pardal, J. Hilakivi, L.A. Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| topic_facet |
Alcohol Behavioral "despair" Desipramine Imipramine Neonatal Nomifensine alcohol desipramine imipramine nomifensine animal experiment behavior intraperitoneal drug administration male newborn nonhuman psychological aspect rat Animal Animals, Newborn Antidepressive Agents Depression Desipramine Ethanol Imipramine Male Motor Activity Nomifensine Rats Rats, Inbred Strains |
| description |
Rat pups were treated with monoamine uptake inhibiting antidepressant drugs, desipramine, imipramine or nomifensine (5 mg/kg) during the second and third postnatal weeks, and their later behavioral "despair," measured by Porsolt's swim test, was examined. At the age of two months, the desipramine-treated rats showed lengthened immobility in the swim test, and thus probably increased behavioral "despair." They also responded to 1 g/kg alcohol by shortening the immobility to the level of control rats. Neonatal treatment with either imipramine or nomifensine did not affect the swim test behavior. The results suggest that a low, stimulatory dose of alcohol was able to reverse the lengthened immobility in the swim test of rats treated with desipramine during the early postnatal period. © 1989. |
| format |
JOUR |
| author |
Fernandez-Pardal, J. Hilakivi, L.A. |
| author_facet |
Fernandez-Pardal, J. Hilakivi, L.A. |
| author_sort |
Fernandez-Pardal, J. |
| title |
Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| title_short |
Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| title_full |
Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| title_fullStr |
Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| title_full_unstemmed |
Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| title_sort |
effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| url |
http://hdl.handle.net/20.500.12110/paper_07418329_v6_n2_p93_FernandezPardal |
| work_keys_str_mv |
AT fernandezpardalj effectoflowalcoholdoseonbehavioraldespairinratsneonatallytreatedwithantidepressantdrugs AT hilakivila effectoflowalcoholdoseonbehavioraldespairinratsneonatallytreatedwithantidepressantdrugs |
| _version_ |
1807315022479622144 |