Spectrofluorimetric assay for the photodegradation products of alprazolam
A new spectrofluorimetric assay for the photodegradation products of the ansiolytic drug alprazolam is described. Alprazolam was found to be highly photolabile and special care should be taken to avoid light exposure during alprazolam storage and handling. The photostability of alprazolam was evalua...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_07317085_v30_n3_p887_Nudelman |
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todo:paper_07317085_v30_n3_p887_Nudelman2023-10-03T15:37:26Z Spectrofluorimetric assay for the photodegradation products of alprazolam Nudelman, N.S. Gallardo Cabrera, C. Alprazolam photostability Alprazolam quality control Alprazolam stability Benzodiazepine phototoxicity Spectrofluorimetric assay alprazolam article drug degradation drug determination drug screening drug stability drug storage fluorescence high performance liquid chromatography light exposure pH photodegradation priority journal spectrofluorometry tablet ultraviolet A radiation ultraviolet B radiation validation process Alprazolam Drug Stability Light Spectrometry, Fluorescence A new spectrofluorimetric assay for the photodegradation products of the ansiolytic drug alprazolam is described. Alprazolam was found to be highly photolabile and special care should be taken to avoid light exposure during alprazolam storage and handling. The photostability of alprazolam was evaluated at pH 2.0, 3.6 and 5.0. The drug was exposed to UVA-UVB radiations, the photodegradation of alprazolam was followed by high-performance liquid chromatographic (HPLC) and the developed spectrofluorimetric assay allowed determination of the photodegradation products at very low concentrations (≥10-5 M). The photoinstability was found to increase with the pH value decreasing, consequently acidic media should be avoided during the drug-development process. © 2002 Elsevier Science B.V. All rights reserved. Fil:Gallardo Cabrera, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_07317085_v30_n3_p887_Nudelman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Alprazolam photostability Alprazolam quality control Alprazolam stability Benzodiazepine phototoxicity Spectrofluorimetric assay alprazolam article drug degradation drug determination drug screening drug stability drug storage fluorescence high performance liquid chromatography light exposure pH photodegradation priority journal spectrofluorometry tablet ultraviolet A radiation ultraviolet B radiation validation process Alprazolam Drug Stability Light Spectrometry, Fluorescence |
| spellingShingle |
Alprazolam photostability Alprazolam quality control Alprazolam stability Benzodiazepine phototoxicity Spectrofluorimetric assay alprazolam article drug degradation drug determination drug screening drug stability drug storage fluorescence high performance liquid chromatography light exposure pH photodegradation priority journal spectrofluorometry tablet ultraviolet A radiation ultraviolet B radiation validation process Alprazolam Drug Stability Light Spectrometry, Fluorescence Nudelman, N.S. Gallardo Cabrera, C. Spectrofluorimetric assay for the photodegradation products of alprazolam |
| topic_facet |
Alprazolam photostability Alprazolam quality control Alprazolam stability Benzodiazepine phototoxicity Spectrofluorimetric assay alprazolam article drug degradation drug determination drug screening drug stability drug storage fluorescence high performance liquid chromatography light exposure pH photodegradation priority journal spectrofluorometry tablet ultraviolet A radiation ultraviolet B radiation validation process Alprazolam Drug Stability Light Spectrometry, Fluorescence |
| description |
A new spectrofluorimetric assay for the photodegradation products of the ansiolytic drug alprazolam is described. Alprazolam was found to be highly photolabile and special care should be taken to avoid light exposure during alprazolam storage and handling. The photostability of alprazolam was evaluated at pH 2.0, 3.6 and 5.0. The drug was exposed to UVA-UVB radiations, the photodegradation of alprazolam was followed by high-performance liquid chromatographic (HPLC) and the developed spectrofluorimetric assay allowed determination of the photodegradation products at very low concentrations (≥10-5 M). The photoinstability was found to increase with the pH value decreasing, consequently acidic media should be avoided during the drug-development process. © 2002 Elsevier Science B.V. All rights reserved. |
| format |
JOUR |
| author |
Nudelman, N.S. Gallardo Cabrera, C. |
| author_facet |
Nudelman, N.S. Gallardo Cabrera, C. |
| author_sort |
Nudelman, N.S. |
| title |
Spectrofluorimetric assay for the photodegradation products of alprazolam |
| title_short |
Spectrofluorimetric assay for the photodegradation products of alprazolam |
| title_full |
Spectrofluorimetric assay for the photodegradation products of alprazolam |
| title_fullStr |
Spectrofluorimetric assay for the photodegradation products of alprazolam |
| title_full_unstemmed |
Spectrofluorimetric assay for the photodegradation products of alprazolam |
| title_sort |
spectrofluorimetric assay for the photodegradation products of alprazolam |
| url |
http://hdl.handle.net/20.500.12110/paper_07317085_v30_n3_p887_Nudelman |
| work_keys_str_mv |
AT nudelmanns spectrofluorimetricassayforthephotodegradationproductsofalprazolam AT gallardocabrerac spectrofluorimetricassayforthephotodegradationproductsofalprazolam |
| _version_ |
1807320594468831232 |