Inhibition of serum-stimulated mitogen activated protein kinase by 1α,25(OH)2-vitamin D3 in MCF-7 breast cancer cells

1α,25-Dihydroxyvitamin D3 [1α,25(OH) 2D3], the hormonally active form of vitamin D3, has been shown to be a potent negative growth regulator of breast cancer cells both in vitro and in vivo. 1α,25(OH)2D3 acts through two different mechanisms. In addition to regulating gene transcription via its spec...

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Detalles Bibliográficos
Autores principales: Capiati, D.A., Rossi, A.M., Picotto, G., Benassati, S., Boland, R.L.
Formato: JOUR
Materias:
1α,25(OH)2D3
Breast cancer cells
MAP kinase
Src
Tyrosine phosphatases
VDR
calcitriol
growth factor
mitogen activated protein kinase
mitogen activated protein kinase 1
mitogen activated protein kinase 3
orthovanadic acid
peptide hormone
protein tyrosine kinase
vitamin D receptor
4 amino 5 (4 methylphenyl) 7 (tert butyl)pyrazolo(3,4 d)pyrimidine
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine
calcitriol receptor
enzyme inhibitor
phosphotyrosine
protein kinase p60
protein tyrosine phosphatase
pyrazole derivative
pyrimidine derivative
article
cell membrane
cell strain MCF 7
drug inhibition
enzyme activity
human
priority journal
signal transduction
transcription regulation
breast tumor
cell nucleus
cell proliferation
drug antagonism
drug effect
enzyme activation
enzymology
metabolism
phosphorylation
protein binding
protein transport
serum
tumor cell line
Breast Neoplasms
Calcitriol
Cell Line, Tumor
Cell Membrane
Cell Nucleus
Cell Proliferation
Enzyme Activation
Enzyme Inhibitors
Humans
Mitogen-Activated Protein Kinases
Phosphorylation
Phosphotyrosine
Protein Binding
Protein Transport
Protein-Tyrosine-Phosphatase
Proto-Oncogene Proteins pp60(c-src)
Pyrazoles
Pyrimidines
Receptors, Calcitriol
Serum
Signal Transduction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_07302312_v93_n2_p384_Capiati
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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