The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system

Molecular expression cloning techniques revealed that patients with the severest clinical form of Chagas disease, chronic Chagas heart disease, presented a strong humoral response against the cloned C-terminal portion of a Trypanosoma cruzi ribosomal P protein. Parasite P antigens identification led...

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Detalles Bibliográficos
Autores principales: Kaplan, D., Vazquez, M., Lafon, S., Schijman, A.G., Levitus, G., Levin, M.J.
Formato: JOUR
Materias:
parasite antigen
ribosome protein
autoimmunity
chagas disease
conference paper
host parasite interaction
molecular cloning
nonhuman
trypanosoma cruzi
Amino Acid Sequence
Animal
Antigens, Protozoan
Autoimmunity
Chagas Disease
Chronic Disease
Comparative Study
Epitopes
Human
Molecular Sequence Data
Protozoan Proteins
Ribosomal Proteins
Support, Non-U.S. Gov't
Trypanosoma cruzi
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_07169760_v26_n1-2_p273_Kaplan
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Molecular expression cloning techniques revealed that patients with the severest clinical form of Chagas disease, chronic Chagas heart disease, presented a strong humoral response against the cloned C-terminal portion of a Trypanosoma cruzi ribosomal P protein. Parasite P antigens identification led to characterize the ribosomal P protein system in T. cruzi. Their exposed location on the ribosome, and the 'amplification' of their parasite specific, serine free C-terminal domain, generate a strong parasite specific anti-P response, that in certain cases may induce anti-P autoimmunity.

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