The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system
Molecular expression cloning techniques revealed that patients with the severest clinical form of Chagas disease, chronic Chagas heart disease, presented a strong humoral response against the cloned C-terminal portion of a Trypanosoma cruzi ribosomal P protein. Parasite P antigens identification led...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_07169760_v26_n1-2_p273_Kaplan |
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todo:paper_07169760_v26_n1-2_p273_Kaplan2023-10-03T15:36:18Z The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system Kaplan, D. Vazquez, M. Lafon, S. Schijman, A.G. Levitus, G. Levin, M.J. parasite antigen ribosome protein autoimmunity chagas disease conference paper host parasite interaction molecular cloning nonhuman trypanosoma cruzi Amino Acid Sequence Animal Antigens, Protozoan Autoimmunity Chagas Disease Chronic Disease Comparative Study Epitopes Human Molecular Sequence Data Protozoan Proteins Ribosomal Proteins Support, Non-U.S. Gov't Trypanosoma cruzi Molecular expression cloning techniques revealed that patients with the severest clinical form of Chagas disease, chronic Chagas heart disease, presented a strong humoral response against the cloned C-terminal portion of a Trypanosoma cruzi ribosomal P protein. Parasite P antigens identification led to characterize the ribosomal P protein system in T. cruzi. Their exposed location on the ribosome, and the 'amplification' of their parasite specific, serine free C-terminal domain, generate a strong parasite specific anti-P response, that in certain cases may induce anti-P autoimmunity. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_07169760_v26_n1-2_p273_Kaplan |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
parasite antigen ribosome protein autoimmunity chagas disease conference paper host parasite interaction molecular cloning nonhuman trypanosoma cruzi Amino Acid Sequence Animal Antigens, Protozoan Autoimmunity Chagas Disease Chronic Disease Comparative Study Epitopes Human Molecular Sequence Data Protozoan Proteins Ribosomal Proteins Support, Non-U.S. Gov't Trypanosoma cruzi |
| spellingShingle |
parasite antigen ribosome protein autoimmunity chagas disease conference paper host parasite interaction molecular cloning nonhuman trypanosoma cruzi Amino Acid Sequence Animal Antigens, Protozoan Autoimmunity Chagas Disease Chronic Disease Comparative Study Epitopes Human Molecular Sequence Data Protozoan Proteins Ribosomal Proteins Support, Non-U.S. Gov't Trypanosoma cruzi Kaplan, D. Vazquez, M. Lafon, S. Schijman, A.G. Levitus, G. Levin, M.J. The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system |
| topic_facet |
parasite antigen ribosome protein autoimmunity chagas disease conference paper host parasite interaction molecular cloning nonhuman trypanosoma cruzi Amino Acid Sequence Animal Antigens, Protozoan Autoimmunity Chagas Disease Chronic Disease Comparative Study Epitopes Human Molecular Sequence Data Protozoan Proteins Ribosomal Proteins Support, Non-U.S. Gov't Trypanosoma cruzi |
| description |
Molecular expression cloning techniques revealed that patients with the severest clinical form of Chagas disease, chronic Chagas heart disease, presented a strong humoral response against the cloned C-terminal portion of a Trypanosoma cruzi ribosomal P protein. Parasite P antigens identification led to characterize the ribosomal P protein system in T. cruzi. Their exposed location on the ribosome, and the 'amplification' of their parasite specific, serine free C-terminal domain, generate a strong parasite specific anti-P response, that in certain cases may induce anti-P autoimmunity. |
| format |
JOUR |
| author |
Kaplan, D. Vazquez, M. Lafon, S. Schijman, A.G. Levitus, G. Levin, M.J. |
| author_facet |
Kaplan, D. Vazquez, M. Lafon, S. Schijman, A.G. Levitus, G. Levin, M.J. |
| author_sort |
Kaplan, D. |
| title |
The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system |
| title_short |
The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system |
| title_full |
The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system |
| title_fullStr |
The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system |
| title_full_unstemmed |
The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: The Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system |
| title_sort |
chronic presence of the parasite, and anti-p autoimmunity in chagas disease: the trypanosoma cruzi ribosomal p proteins, and their recognition by the host immune system |
| url |
http://hdl.handle.net/20.500.12110/paper_07169760_v26_n1-2_p273_Kaplan |
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