Steroid protection in aging and age-associated diseases

Neuroactive steroids are secretory products of peripheral endocrine glands that modulate a variety of brain functions. A close relationship between neuroactive steroid structure and function becomes most evident under pathological circumstances. On one side, overproduction of glucocorticoid and mine...

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Autores principales:	De Nicola, A.F., Pietranera, L., Beauquis, J., Ferrini, M.G., Saravia, F.E.
Formato:	JOUR
Materias:	Aging Arginine vasopressin Astrogliosis Diabetes mellitus Estradiol Hypertension Neurogenesis Neuroprotection argipressin corticosterone dexamethasone hydrocortisone mineralocorticoid receptor aging Alzheimer disease astrocytosis dentate gyrus hippocampus human hypertension nervous system development neuroprotection nonhuman priority journal short survey steroid metabolism streptozocin diabetes Adrenal Cortex Aged Animals Diabetes Mellitus Glucocorticoids Hippocampus Humans Middle Aged Mineralocorticoids Neuroprotective Agents Rats Rats, Inbred Strains Animalia Mus Rattus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_05315565_v44_n1-2_p34_DeNicola
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_05315565_v44_n1-2_p34_DeNicola
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spelling	todo:paper_05315565_v44_n1-2_p34_DeNicola2023-10-03T15:34:11Z Steroid protection in aging and age-associated diseases De Nicola, A.F. Pietranera, L. Beauquis, J. Ferrini, M.G. Saravia, F.E. Aging Arginine vasopressin Astrogliosis Diabetes mellitus Estradiol Hypertension Neurogenesis Neuroprotection argipressin corticosterone dexamethasone hydrocortisone mineralocorticoid receptor aging Alzheimer disease astrocytosis dentate gyrus hippocampus human hypertension nervous system development neuroprotection nonhuman priority journal short survey steroid metabolism streptozocin diabetes Adrenal Cortex Aged Aging Animals Diabetes Mellitus Estradiol Glucocorticoids Hippocampus Humans Hypertension Middle Aged Mineralocorticoids Neuroprotective Agents Rats Rats, Inbred Strains Animalia Mus Rattus Neuroactive steroids are secretory products of peripheral endocrine glands that modulate a variety of brain functions. A close relationship between neuroactive steroid structure and function becomes most evident under pathological circumstances. On one side, overproduction of glucocorticoid and mineralocorticoid neuroactive steroids may be detrimental to the hippocampus, which is enriched in glucocorticoid receptors (GR) and mineralocorticoid receptors (MR). Thus, a dysfunction of the adrenocortical system in aging and age-associated diseases (diabetes, hypertension) is able to cause hippocampal damage. Whereas aging and uncontrolled diabetes show a predominant GR overdrive, a MR overdrive characterizes hypertensive animals. Some abnormalities commonly found in the hippocampus of aging, diabetic and hypertensive animals include decreased neurogenesis, astrogliosis and neuronal loss in the hilus of the dentate gyrus (DG). On the other side, and in contrast to adrenal gland-derived steroids, estrogens qualify as hippocampal neuroprotectants. Given to middle-age mice, estrogens stimulated proliferation and differentiation of newborn cells in the DG, decreased astrogliosis and increased hilar neuronal number. Similar estrogen effects were obtained in mice with streptozotocin-induced diabetes and in spontaneously hypertensive rats (SHR). The results suggest that in aging and age-associated diseases, adrenocortical steroid overdrive sensitizes the hippocampus to the pathological milieu imposed by a pre-existing degeneration or illness. In this setting, estradiol neuroprotection rescues hippocampal parameters previously altered by the pathological environment. © 2008 Elsevier Inc. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_05315565_v44_n1-2_p34_DeNicola
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Aging Arginine vasopressin Astrogliosis Diabetes mellitus Estradiol Hypertension Neurogenesis Neuroprotection argipressin corticosterone dexamethasone hydrocortisone mineralocorticoid receptor aging Alzheimer disease astrocytosis dentate gyrus hippocampus human hypertension nervous system development neuroprotection nonhuman priority journal short survey steroid metabolism streptozocin diabetes Adrenal Cortex Aged Aging Animals Diabetes Mellitus Estradiol Glucocorticoids Hippocampus Humans Hypertension Middle Aged Mineralocorticoids Neuroprotective Agents Rats Rats, Inbred Strains Animalia Mus Rattus
spellingShingle	Aging Arginine vasopressin Astrogliosis Diabetes mellitus Estradiol Hypertension Neurogenesis Neuroprotection argipressin corticosterone dexamethasone hydrocortisone mineralocorticoid receptor aging Alzheimer disease astrocytosis dentate gyrus hippocampus human hypertension nervous system development neuroprotection nonhuman priority journal short survey steroid metabolism streptozocin diabetes Adrenal Cortex Aged Aging Animals Diabetes Mellitus Estradiol Glucocorticoids Hippocampus Humans Hypertension Middle Aged Mineralocorticoids Neuroprotective Agents Rats Rats, Inbred Strains Animalia Mus Rattus De Nicola, A.F. Pietranera, L. Beauquis, J. Ferrini, M.G. Saravia, F.E. Steroid protection in aging and age-associated diseases
topic_facet	Aging Arginine vasopressin Astrogliosis Diabetes mellitus Estradiol Hypertension Neurogenesis Neuroprotection argipressin corticosterone dexamethasone hydrocortisone mineralocorticoid receptor aging Alzheimer disease astrocytosis dentate gyrus hippocampus human hypertension nervous system development neuroprotection nonhuman priority journal short survey steroid metabolism streptozocin diabetes Adrenal Cortex Aged Aging Animals Diabetes Mellitus Estradiol Glucocorticoids Hippocampus Humans Hypertension Middle Aged Mineralocorticoids Neuroprotective Agents Rats Rats, Inbred Strains Animalia Mus Rattus
description	Neuroactive steroids are secretory products of peripheral endocrine glands that modulate a variety of brain functions. A close relationship between neuroactive steroid structure and function becomes most evident under pathological circumstances. On one side, overproduction of glucocorticoid and mineralocorticoid neuroactive steroids may be detrimental to the hippocampus, which is enriched in glucocorticoid receptors (GR) and mineralocorticoid receptors (MR). Thus, a dysfunction of the adrenocortical system in aging and age-associated diseases (diabetes, hypertension) is able to cause hippocampal damage. Whereas aging and uncontrolled diabetes show a predominant GR overdrive, a MR overdrive characterizes hypertensive animals. Some abnormalities commonly found in the hippocampus of aging, diabetic and hypertensive animals include decreased neurogenesis, astrogliosis and neuronal loss in the hilus of the dentate gyrus (DG). On the other side, and in contrast to adrenal gland-derived steroids, estrogens qualify as hippocampal neuroprotectants. Given to middle-age mice, estrogens stimulated proliferation and differentiation of newborn cells in the DG, decreased astrogliosis and increased hilar neuronal number. Similar estrogen effects were obtained in mice with streptozotocin-induced diabetes and in spontaneously hypertensive rats (SHR). The results suggest that in aging and age-associated diseases, adrenocortical steroid overdrive sensitizes the hippocampus to the pathological milieu imposed by a pre-existing degeneration or illness. In this setting, estradiol neuroprotection rescues hippocampal parameters previously altered by the pathological environment. © 2008 Elsevier Inc. All rights reserved.
format	JOUR
author	De Nicola, A.F. Pietranera, L. Beauquis, J. Ferrini, M.G. Saravia, F.E.
author_facet	De Nicola, A.F. Pietranera, L. Beauquis, J. Ferrini, M.G. Saravia, F.E.
author_sort	De Nicola, A.F.
title	Steroid protection in aging and age-associated diseases
title_short	Steroid protection in aging and age-associated diseases
title_full	Steroid protection in aging and age-associated diseases
title_fullStr	Steroid protection in aging and age-associated diseases
title_full_unstemmed	Steroid protection in aging and age-associated diseases
title_sort	steroid protection in aging and age-associated diseases
url	http://hdl.handle.net/20.500.12110/paper_05315565_v44_n1-2_p34_DeNicola
work_keys_str_mv	AT denicolaaf steroidprotectioninagingandageassociateddiseases AT pietraneral steroidprotectioninagingandageassociateddiseases AT beauquisj steroidprotectioninagingandageassociateddiseases AT ferrinimg steroidprotectioninagingandageassociateddiseases AT saraviafe steroidprotectioninagingandageassociateddiseases
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Steroid protection in aging and age-associated diseases

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