Perspectives for the Therapy against Arenavirus Infections

Five arenaviruses are able to cause severe hemorrhagic fevers (HF) in humans, and two of them, Lassa virus and Junin virus generate periodic annual outbreaks of severe hemorrhagic fever with high mortality rate in West Africa and Argentina, respectively. This chapter describes the drawbacks of the p...

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Detalles Bibliográficos
Autores principales: Damonte, E.B., García, C.C.
Formato: CHAP
Materias:
Antiviral therapy
Arenavirus
Assembly
Budding
Hemorrhagic fever
Junin Virus
Lassa Virus
Replicative cycle
Virus entry
Virus maturation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_04716682_v_n_p115_Damonte
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_04716682_v_n_p115_Damonte2023-10-03T15:34:08Z Perspectives for the Therapy against Arenavirus Infections Damonte, E.B. García, C.C. Antiviral therapy Arenavirus Assembly Budding Hemorrhagic fever Junin Virus Lassa Virus Replicative cycle Virus entry Virus maturation Five arenaviruses are able to cause severe hemorrhagic fevers (HF) in humans, and two of them, Lassa virus and Junin virus generate periodic annual outbreaks of severe hemorrhagic fever with high mortality rate in West Africa and Argentina, respectively. This chapter describes the drawbacks of the present treatment of arenavirus HF, mainly based on the administration of immune plasma or the drug ribavirin, and the future perspectives for therapy, mainly focused on new possible targets in early and late stages of the replicative cycle, responsible of viral entry to the cell and virus maturation, assembly and budding, respectively. © 2005 John Wiley & Sons, Inc. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:García, C.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. CHAP info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_04716682_v_n_p115_Damonte
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Antiviral therapy
Arenavirus
Assembly
Budding
Hemorrhagic fever
Junin Virus
Lassa Virus
Replicative cycle
Virus entry
Virus maturation
spellingShingle Antiviral therapy
Arenavirus
Assembly
Budding
Hemorrhagic fever
Junin Virus
Lassa Virus
Replicative cycle
Virus entry
Virus maturation
Damonte, E.B.
García, C.C.
Perspectives for the Therapy against Arenavirus Infections
topic_facet Antiviral therapy
Arenavirus
Assembly
Budding
Hemorrhagic fever
Junin Virus
Lassa Virus
Replicative cycle
Virus entry
Virus maturation
description Five arenaviruses are able to cause severe hemorrhagic fevers (HF) in humans, and two of them, Lassa virus and Junin virus generate periodic annual outbreaks of severe hemorrhagic fever with high mortality rate in West Africa and Argentina, respectively. This chapter describes the drawbacks of the present treatment of arenavirus HF, mainly based on the administration of immune plasma or the drug ribavirin, and the future perspectives for therapy, mainly focused on new possible targets in early and late stages of the replicative cycle, responsible of viral entry to the cell and virus maturation, assembly and budding, respectively. © 2005 John Wiley & Sons, Inc.
format CHAP
author Damonte, E.B.
García, C.C.
author_facet Damonte, E.B.
García, C.C.
author_sort Damonte, E.B.
title Perspectives for the Therapy against Arenavirus Infections
title_short Perspectives for the Therapy against Arenavirus Infections
title_full Perspectives for the Therapy against Arenavirus Infections
title_fullStr Perspectives for the Therapy against Arenavirus Infections
title_full_unstemmed Perspectives for the Therapy against Arenavirus Infections
title_sort perspectives for the therapy against arenavirus infections
url http://hdl.handle.net/20.500.12110/paper_04716682_v_n_p115_Damonte
work_keys_str_mv AT damonteeb perspectivesforthetherapyagainstarenavirusinfections
AT garciacc perspectivesforthetherapyagainstarenavirusinfections
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