Lymphadenopathy secondary to silicone hand joint prostheses

The occurrence of lymphadenopathies was investigated in 23 patients with diverse rheumatic conditions who had silastic prosthesis in joints of the hands, to determine whether these adenopathies were due to the presence of silicone particles. Five cases had clinically detectable lymph node enlargemen...

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Autores principales:	Lazaro, M.A., Garcia Morteo, D., De Benyacar, M.A., Paira, S.O., Lema, B., Garcia Morteo, O., Maldonado Cocco, J.A.
Formato:	JOUR
Materias:	silicone arthroplasty article clinical article giant cell granulomatosis hand histology human lymphadenopathy osteoarthritis rheumatoid arthritis ultrastructure wrist X ray spectrometry Adult Aged Arthritis, Rheumatoid Electron Probe Microanalysis Female Hand Human Joint Prosthesis Lymphatic Diseases Male Middle Age Silicones
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0392856X_v8_n1_p17_Lazaro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_0392856X_v8_n1_p17_Lazaro
record_format	dspace
spelling	todo:paper_0392856X_v8_n1_p17_Lazaro2023-10-03T15:33:53Z Lymphadenopathy secondary to silicone hand joint prostheses Lazaro, M.A. Garcia Morteo, D. De Benyacar, M.A. Paira, S.O. Lema, B. Garcia Morteo, O. Maldonado Cocco, J.A. silicone arthroplasty article clinical article giant cell granulomatosis hand histology human lymphadenopathy osteoarthritis rheumatoid arthritis ultrastructure wrist X ray spectrometry Adult Aged Arthritis, Rheumatoid Electron Probe Microanalysis Female Hand Human Joint Prosthesis Lymphatic Diseases Male Middle Age Silicones The occurrence of lymphadenopathies was investigated in 23 patients with diverse rheumatic conditions who had silastic prosthesis in joints of the hands, to determine whether these adenopathies were due to the presence of silicone particles. Five cases had clinically detectable lymph node enlargement and tissue samples were studied by light and scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDXA). In 3 out of the 5 cases foreign body granulomas were observed by light microscopy, SEM showing a highly irregular distribution of foreign body material with a peak for silicone by EDXA. Foreign body particle distribution closely correlated with silicone concentration. No granulomas were found in the two remaining patients with adenopathies who presented a non-specific reactive lymphadenitis. Our findings show that silicone lymphadenopathy is a more frequent complication (13%) of silastic arthroplasty than is usually recognized and therefore should be considered in the differential diagnosis of patients with lymph node enlargement who have previously received a silicone arthroplasty. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0392856X_v8_n1_p17_Lazaro
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	silicone arthroplasty article clinical article giant cell granulomatosis hand histology human lymphadenopathy osteoarthritis rheumatoid arthritis ultrastructure wrist X ray spectrometry Adult Aged Arthritis, Rheumatoid Electron Probe Microanalysis Female Hand Human Joint Prosthesis Lymphatic Diseases Male Middle Age Silicones
spellingShingle	silicone arthroplasty article clinical article giant cell granulomatosis hand histology human lymphadenopathy osteoarthritis rheumatoid arthritis ultrastructure wrist X ray spectrometry Adult Aged Arthritis, Rheumatoid Electron Probe Microanalysis Female Hand Human Joint Prosthesis Lymphatic Diseases Male Middle Age Silicones Lazaro, M.A. Garcia Morteo, D. De Benyacar, M.A. Paira, S.O. Lema, B. Garcia Morteo, O. Maldonado Cocco, J.A. Lymphadenopathy secondary to silicone hand joint prostheses
topic_facet	silicone arthroplasty article clinical article giant cell granulomatosis hand histology human lymphadenopathy osteoarthritis rheumatoid arthritis ultrastructure wrist X ray spectrometry Adult Aged Arthritis, Rheumatoid Electron Probe Microanalysis Female Hand Human Joint Prosthesis Lymphatic Diseases Male Middle Age Silicones
description	The occurrence of lymphadenopathies was investigated in 23 patients with diverse rheumatic conditions who had silastic prosthesis in joints of the hands, to determine whether these adenopathies were due to the presence of silicone particles. Five cases had clinically detectable lymph node enlargement and tissue samples were studied by light and scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDXA). In 3 out of the 5 cases foreign body granulomas were observed by light microscopy, SEM showing a highly irregular distribution of foreign body material with a peak for silicone by EDXA. Foreign body particle distribution closely correlated with silicone concentration. No granulomas were found in the two remaining patients with adenopathies who presented a non-specific reactive lymphadenitis. Our findings show that silicone lymphadenopathy is a more frequent complication (13%) of silastic arthroplasty than is usually recognized and therefore should be considered in the differential diagnosis of patients with lymph node enlargement who have previously received a silicone arthroplasty.
format	JOUR
author	Lazaro, M.A. Garcia Morteo, D. De Benyacar, M.A. Paira, S.O. Lema, B. Garcia Morteo, O. Maldonado Cocco, J.A.
author_facet	Lazaro, M.A. Garcia Morteo, D. De Benyacar, M.A. Paira, S.O. Lema, B. Garcia Morteo, O. Maldonado Cocco, J.A.
author_sort	Lazaro, M.A.
title	Lymphadenopathy secondary to silicone hand joint prostheses
title_short	Lymphadenopathy secondary to silicone hand joint prostheses
title_full	Lymphadenopathy secondary to silicone hand joint prostheses
title_fullStr	Lymphadenopathy secondary to silicone hand joint prostheses
title_full_unstemmed	Lymphadenopathy secondary to silicone hand joint prostheses
title_sort	lymphadenopathy secondary to silicone hand joint prostheses
url	http://hdl.handle.net/20.500.12110/paper_0392856X_v8_n1_p17_Lazaro
work_keys_str_mv	AT lazaroma lymphadenopathysecondarytosiliconehandjointprostheses AT garciamorteod lymphadenopathysecondarytosiliconehandjointprostheses AT debenyacarma lymphadenopathysecondarytosiliconehandjointprostheses AT pairaso lymphadenopathysecondarytosiliconehandjointprostheses AT lemab lymphadenopathysecondarytosiliconehandjointprostheses AT garciamorteoo lymphadenopathysecondarytosiliconehandjointprostheses AT maldonadococcoja lymphadenopathysecondarytosiliconehandjointprostheses
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Lymphadenopathy secondary to silicone hand joint prostheses

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