Hepatic indices of thyroid status in rats treated with hexachlorobenzene
The functional thyroid status of hexachlorobenzene (HCB)-treated rats was studied. HCB caused a depletion of serum thyroxine (T4 ), but did not change L-3,5,3’-triiodothyronine (T3) levels in serum of rats. The activities of the thyroid regulated mitochondrial enzyme L-glycerolphosphate dehydrogenas...
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todo:paper_03914097_v18_n4_p271_dePisarev2023-10-03T15:33:48Z Hepatic indices of thyroid status in rats treated with hexachlorobenzene de Pisarev, D.L.K. de Sancovich, A.M.F. Sancovich, H.A. 6-phosphogluconate dehydrogenase glucose-6-phosphate dehydrogenase Hexachlorobenzene L-glycerolphosphate dehydrogenase malic enzyme triiodothyronine glucose 6 phosphate dehydrogenase glycerol 3 phosphate dehydrogenase hexachlorobenzene liothyronine liver enzyme malate dehydrogenase (decarboxylating) mitochondrial enzyme phosphogluconate dehydrogenase thyrotropin thyroxine animal experiment animal model article controlled study enzyme activity enzyme induction female liothyronine blood level liver function nonhuman rat thyroid function thyrotropin blood level thyroxine blood level Animal Body Weight Female Glucosephosphate Dehydrogenase Glycerolphosphate Dehydrogenase Hexachlorobenzene Liver Malate Dehydrogenase Organ Weight Phosphogluconate Dehydrogenase Rats Rats, Wistar Support, Non-U.S. Gov't Thyroid Gland Thyroid Hormones The functional thyroid status of hexachlorobenzene (HCB)-treated rats was studied. HCB caused a depletion of serum thyroxine (T4 ), but did not change L-3,5,3’-triiodothyronine (T3) levels in serum of rats. The activities of the thyroid regulated mitochondrial enzyme L-glycerolphosphate dehydrogenase (LGPD) and cytosolic enzymes, malic enzyme (ME), glucose-6-phosphate dehydrogenase (G6PD) and 6-phos-phogluconate dehydrogenase (6PGD) were assayed in livers of normal and HCB (100 mg/100 g bw) treated Wistar rats. Mitochondrial LGPD activity did not change significantly, however ME, 6GPD and G6PD were induced by HCB only in non-thyroidectomized animals. The absence of cytosolic enzymes induction in thyroidectomized rats treated with HCB indicates that HCB is not intrinsically thyromimetic. The induction of hepatic ME, G6PD and 6PGD activities in HCB thyroidectomized rats was dependent on the presence of thyroid hormone. The unchanged activity of mitochondrial LGPD in contrast to the increased activities of the cytosolic enzymes ME, G6PD and 6PGD is not consistent with a shift in functional thyroid status following HCB treatment. © 1995, Italian Society of Endocrinology (SIE). All rights reserved. Fil:Sancovich, H.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03914097_v18_n4_p271_dePisarev |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
6-phosphogluconate dehydrogenase glucose-6-phosphate dehydrogenase Hexachlorobenzene L-glycerolphosphate dehydrogenase malic enzyme triiodothyronine glucose 6 phosphate dehydrogenase glycerol 3 phosphate dehydrogenase hexachlorobenzene liothyronine liver enzyme malate dehydrogenase (decarboxylating) mitochondrial enzyme phosphogluconate dehydrogenase thyrotropin thyroxine animal experiment animal model article controlled study enzyme activity enzyme induction female liothyronine blood level liver function nonhuman rat thyroid function thyrotropin blood level thyroxine blood level Animal Body Weight Female Glucosephosphate Dehydrogenase Glycerolphosphate Dehydrogenase Hexachlorobenzene Liver Malate Dehydrogenase Organ Weight Phosphogluconate Dehydrogenase Rats Rats, Wistar Support, Non-U.S. Gov't Thyroid Gland Thyroid Hormones |
| spellingShingle |
6-phosphogluconate dehydrogenase glucose-6-phosphate dehydrogenase Hexachlorobenzene L-glycerolphosphate dehydrogenase malic enzyme triiodothyronine glucose 6 phosphate dehydrogenase glycerol 3 phosphate dehydrogenase hexachlorobenzene liothyronine liver enzyme malate dehydrogenase (decarboxylating) mitochondrial enzyme phosphogluconate dehydrogenase thyrotropin thyroxine animal experiment animal model article controlled study enzyme activity enzyme induction female liothyronine blood level liver function nonhuman rat thyroid function thyrotropin blood level thyroxine blood level Animal Body Weight Female Glucosephosphate Dehydrogenase Glycerolphosphate Dehydrogenase Hexachlorobenzene Liver Malate Dehydrogenase Organ Weight Phosphogluconate Dehydrogenase Rats Rats, Wistar Support, Non-U.S. Gov't Thyroid Gland Thyroid Hormones de Pisarev, D.L.K. de Sancovich, A.M.F. Sancovich, H.A. Hepatic indices of thyroid status in rats treated with hexachlorobenzene |
| topic_facet |
6-phosphogluconate dehydrogenase glucose-6-phosphate dehydrogenase Hexachlorobenzene L-glycerolphosphate dehydrogenase malic enzyme triiodothyronine glucose 6 phosphate dehydrogenase glycerol 3 phosphate dehydrogenase hexachlorobenzene liothyronine liver enzyme malate dehydrogenase (decarboxylating) mitochondrial enzyme phosphogluconate dehydrogenase thyrotropin thyroxine animal experiment animal model article controlled study enzyme activity enzyme induction female liothyronine blood level liver function nonhuman rat thyroid function thyrotropin blood level thyroxine blood level Animal Body Weight Female Glucosephosphate Dehydrogenase Glycerolphosphate Dehydrogenase Hexachlorobenzene Liver Malate Dehydrogenase Organ Weight Phosphogluconate Dehydrogenase Rats Rats, Wistar Support, Non-U.S. Gov't Thyroid Gland Thyroid Hormones |
| description |
The functional thyroid status of hexachlorobenzene (HCB)-treated rats was studied. HCB caused a depletion of serum thyroxine (T4 ), but did not change L-3,5,3’-triiodothyronine (T3) levels in serum of rats. The activities of the thyroid regulated mitochondrial enzyme L-glycerolphosphate dehydrogenase (LGPD) and cytosolic enzymes, malic enzyme (ME), glucose-6-phosphate dehydrogenase (G6PD) and 6-phos-phogluconate dehydrogenase (6PGD) were assayed in livers of normal and HCB (100 mg/100 g bw) treated Wistar rats. Mitochondrial LGPD activity did not change significantly, however ME, 6GPD and G6PD were induced by HCB only in non-thyroidectomized animals. The absence of cytosolic enzymes induction in thyroidectomized rats treated with HCB indicates that HCB is not intrinsically thyromimetic. The induction of hepatic ME, G6PD and 6PGD activities in HCB thyroidectomized rats was dependent on the presence of thyroid hormone. The unchanged activity of mitochondrial LGPD in contrast to the increased activities of the cytosolic enzymes ME, G6PD and 6PGD is not consistent with a shift in functional thyroid status following HCB treatment. © 1995, Italian Society of Endocrinology (SIE). All rights reserved. |
| format |
JOUR |
| author |
de Pisarev, D.L.K. de Sancovich, A.M.F. Sancovich, H.A. |
| author_facet |
de Pisarev, D.L.K. de Sancovich, A.M.F. Sancovich, H.A. |
| author_sort |
de Pisarev, D.L.K. |
| title |
Hepatic indices of thyroid status in rats treated with hexachlorobenzene |
| title_short |
Hepatic indices of thyroid status in rats treated with hexachlorobenzene |
| title_full |
Hepatic indices of thyroid status in rats treated with hexachlorobenzene |
| title_fullStr |
Hepatic indices of thyroid status in rats treated with hexachlorobenzene |
| title_full_unstemmed |
Hepatic indices of thyroid status in rats treated with hexachlorobenzene |
| title_sort |
hepatic indices of thyroid status in rats treated with hexachlorobenzene |
| url |
http://hdl.handle.net/20.500.12110/paper_03914097_v18_n4_p271_dePisarev |
| work_keys_str_mv |
AT depisarevdlk hepaticindicesofthyroidstatusinratstreatedwithhexachlorobenzene AT desancovichamf hepaticindicesofthyroidstatusinratstreatedwithhexachlorobenzene AT sancovichha hepaticindicesofthyroidstatusinratstreatedwithhexachlorobenzene |
| _version_ |
1807322404723097600 |