Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria

The role of thyroid status in hexachlorobenzene (HBC) induced porphyria was studied in normal, thyroidectomized and thyroxine (T4) treated rats. Female Wistar rats were treated with HCB for different periods of time. Serum T4 levels were depressed after 8 days of HCB administration whereas levels of...

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Autores principales:	Sopena de Kracoff, Y.E., Ferramola de Sancovich, A.M., Sancovich, H.A., de Pisarev, D.L.K.
Formato:	JOUR
Materias:	hexachlorobenzene porphyria porphyrinogen carboxy-liase thyroid status Thyroxine liothyronine thyrotropin thyroxine uroporphyrinogen decarboxylase animal experiment animal model article controlled study enzyme activity female hyperthyroxinemia liothyronine blood level nonhuman rat thyroidectomy thyrotropin blood level thyroxine blood level Animal Carboxy-Lyases Female Hexachlorobenzene Porphyria Rats Rats, Wistar Support, Non-U.S. Gov't Thyroidectomy Triiodothyronine
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03914097_v17_n5_p301_SopenadeKracoff
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_03914097_v17_n5_p301_SopenadeKracoff2023-10-03T15:33:48Z Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria Sopena de Kracoff, Y.E. Ferramola de Sancovich, A.M. Sancovich, H.A. de Pisarev, D.L.K. hexachlorobenzene porphyria porphyrinogen carboxy-liase thyroid status Thyroxine hexachlorobenzene liothyronine thyrotropin thyroxine uroporphyrinogen decarboxylase animal experiment animal model article controlled study enzyme activity female hyperthyroxinemia liothyronine blood level nonhuman porphyria rat thyroidectomy thyrotropin blood level thyroxine blood level Animal Carboxy-Lyases Female Hexachlorobenzene Porphyria Rats Rats, Wistar Support, Non-U.S. Gov't Thyroidectomy Thyroxine Triiodothyronine The role of thyroid status in hexachlorobenzene (HBC) induced porphyria was studied in normal, thyroidectomized and thyroxine (T4) treated rats. Female Wistar rats were treated with HCB for different periods of time. Serum T4 levels were depressed after 8 days of HCB administration whereas levels of triiodothyronine (T3) were not altered. T4 administered simultaneously with HCB resulted in hyperthyroxinemia. The time course of porphyrinogen carboxy-lyase (PCL) activity in the three HBC treated groups was studied. A rapid and significant decrease of PCL activity was found after 8 days of HCB treatment in T4 treated rats with respect to untreated animals. In contrast, HCB treatment of normal and thyroidectomized rats elicited a significant decrease of PCL activity after 21 and 30 days, respectively. This study shows that thyroid hormone plays an important role in the early establishment of HCB induced porphyria. © 1994, Italian Society of Endocrinology (SIE). All rights reserved. Fil:Sopena de Kracoff, Y.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ferramola de Sancovich, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sancovich, H.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03914097_v17_n5_p301_SopenadeKracoff
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	hexachlorobenzene porphyria porphyrinogen carboxy-liase thyroid status Thyroxine hexachlorobenzene liothyronine thyrotropin thyroxine uroporphyrinogen decarboxylase animal experiment animal model article controlled study enzyme activity female hyperthyroxinemia liothyronine blood level nonhuman porphyria rat thyroidectomy thyrotropin blood level thyroxine blood level Animal Carboxy-Lyases Female Hexachlorobenzene Porphyria Rats Rats, Wistar Support, Non-U.S. Gov't Thyroidectomy Thyroxine Triiodothyronine
spellingShingle	hexachlorobenzene porphyria porphyrinogen carboxy-liase thyroid status Thyroxine hexachlorobenzene liothyronine thyrotropin thyroxine uroporphyrinogen decarboxylase animal experiment animal model article controlled study enzyme activity female hyperthyroxinemia liothyronine blood level nonhuman porphyria rat thyroidectomy thyrotropin blood level thyroxine blood level Animal Carboxy-Lyases Female Hexachlorobenzene Porphyria Rats Rats, Wistar Support, Non-U.S. Gov't Thyroidectomy Thyroxine Triiodothyronine Sopena de Kracoff, Y.E. Ferramola de Sancovich, A.M. Sancovich, H.A. de Pisarev, D.L.K. Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria
topic_facet	hexachlorobenzene porphyria porphyrinogen carboxy-liase thyroid status Thyroxine hexachlorobenzene liothyronine thyrotropin thyroxine uroporphyrinogen decarboxylase animal experiment animal model article controlled study enzyme activity female hyperthyroxinemia liothyronine blood level nonhuman porphyria rat thyroidectomy thyrotropin blood level thyroxine blood level Animal Carboxy-Lyases Female Hexachlorobenzene Porphyria Rats Rats, Wistar Support, Non-U.S. Gov't Thyroidectomy Thyroxine Triiodothyronine
description	The role of thyroid status in hexachlorobenzene (HBC) induced porphyria was studied in normal, thyroidectomized and thyroxine (T4) treated rats. Female Wistar rats were treated with HCB for different periods of time. Serum T4 levels were depressed after 8 days of HCB administration whereas levels of triiodothyronine (T3) were not altered. T4 administered simultaneously with HCB resulted in hyperthyroxinemia. The time course of porphyrinogen carboxy-lyase (PCL) activity in the three HBC treated groups was studied. A rapid and significant decrease of PCL activity was found after 8 days of HCB treatment in T4 treated rats with respect to untreated animals. In contrast, HCB treatment of normal and thyroidectomized rats elicited a significant decrease of PCL activity after 21 and 30 days, respectively. This study shows that thyroid hormone plays an important role in the early establishment of HCB induced porphyria. © 1994, Italian Society of Endocrinology (SIE). All rights reserved.
format	JOUR
author	Sopena de Kracoff, Y.E. Ferramola de Sancovich, A.M. Sancovich, H.A. de Pisarev, D.L.K.
author_facet	Sopena de Kracoff, Y.E. Ferramola de Sancovich, A.M. Sancovich, H.A. de Pisarev, D.L.K.
author_sort	Sopena de Kracoff, Y.E.
title	Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria
title_short	Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria
title_full	Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria
title_fullStr	Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria
title_full_unstemmed	Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria
title_sort	effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria
url	http://hdl.handle.net/20.500.12110/paper_03914097_v17_n5_p301_SopenadeKracoff
work_keys_str_mv	AT sopenadekracoffye effectofthyroidectomyandthyroxineonhexachlorobenzeneinducedporphyria AT ferramoladesancovicham effectofthyroidectomyandthyroxineonhexachlorobenzeneinducedporphyria AT sancovichha effectofthyroidectomyandthyroxineonhexachlorobenzeneinducedporphyria AT depisarevdlk effectofthyroidectomyandthyroxineonhexachlorobenzeneinducedporphyria
_version_	1807323714224652288

Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria

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