Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats

The effect of hexachlorobenzene (HCB) (1 g/kg bw) administration for 4 weeks, on thyroxine (T4) and triiodothyronine (T3) metabolism was studied in Wistar rats. The effect on serum binding of T4 has also been studied. Animals were injected with a tracer dose of either labeled hormone and by examinin...

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Autores principales:	Kleiman de Pisarev, D.L., Sancovich, H.A., Ferramola de Sancovich, A.M.
Formato:	JOUR
Materias:	deiodination hexachlorobenzene intoxication thyroid hormones Thyroxine triiodothyronine liothyronine radioisotope thyrotropin thyroxine animal experiment article kinetics metabolic clearance rate nonhuman priority journal rat Animal Blood Proteins Chlorobenzenes Female Hexachlorobenzene Iodine Radioisotopes Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Triiodothyronine
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03914097_v12_n11_p767_KleimandePisarev
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_03914097_v12_n11_p767_KleimandePisarev2023-10-03T15:33:47Z Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats Kleiman de Pisarev, D.L. Sancovich, H.A. Ferramola de Sancovich, A.M. deiodination hexachlorobenzene intoxication thyroid hormones Thyroxine triiodothyronine hexachlorobenzene liothyronine radioisotope thyrotropin thyroxine animal experiment article deiodination intoxication kinetics metabolic clearance rate nonhuman priority journal rat Animal Blood Proteins Chlorobenzenes Female Hexachlorobenzene Iodine Radioisotopes Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine The effect of hexachlorobenzene (HCB) (1 g/kg bw) administration for 4 weeks, on thyroxine (T4) and triiodothyronine (T3) metabolism was studied in Wistar rats. The effect on serum binding of T4 has also been studied. Animals were injected with a tracer dose of either labeled hormone and by examining serum L-125I-T4 and L-125-I-T3, kinetics of radiolabeled hormones metabolism were calculated. The T4 metabolic clearance (MCI) as well as the distribution space, were increased by 6 fold. Decreased serum T4 levels result from an increase both in deiodinative and fecal disposal in HCB-treated rats. 125I-T3 metabolism was slightly affected. The enhanced peripheral disposition of thyroxine appears to lead to increased thyroid function, as measured by augmented TSH serum levels and 125I-thyroidal uptake. Serum binding of T4 was not affected. © 1989, Italian Society of Endocrinology (SIE). All rights reserved. Fil:Kleiman de Pisarev, D.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sancovich, H.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ferramola de Sancovich, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03914097_v12_n11_p767_KleimandePisarev
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	deiodination hexachlorobenzene intoxication thyroid hormones Thyroxine triiodothyronine hexachlorobenzene liothyronine radioisotope thyrotropin thyroxine animal experiment article deiodination intoxication kinetics metabolic clearance rate nonhuman priority journal rat Animal Blood Proteins Chlorobenzenes Female Hexachlorobenzene Iodine Radioisotopes Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine
spellingShingle	deiodination hexachlorobenzene intoxication thyroid hormones Thyroxine triiodothyronine hexachlorobenzene liothyronine radioisotope thyrotropin thyroxine animal experiment article deiodination intoxication kinetics metabolic clearance rate nonhuman priority journal rat Animal Blood Proteins Chlorobenzenes Female Hexachlorobenzene Iodine Radioisotopes Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine Kleiman de Pisarev, D.L. Sancovich, H.A. Ferramola de Sancovich, A.M. Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats
topic_facet	deiodination hexachlorobenzene intoxication thyroid hormones Thyroxine triiodothyronine hexachlorobenzene liothyronine radioisotope thyrotropin thyroxine animal experiment article deiodination intoxication kinetics metabolic clearance rate nonhuman priority journal rat Animal Blood Proteins Chlorobenzenes Female Hexachlorobenzene Iodine Radioisotopes Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine
description	The effect of hexachlorobenzene (HCB) (1 g/kg bw) administration for 4 weeks, on thyroxine (T4) and triiodothyronine (T3) metabolism was studied in Wistar rats. The effect on serum binding of T4 has also been studied. Animals were injected with a tracer dose of either labeled hormone and by examining serum L-125I-T4 and L-125-I-T3, kinetics of radiolabeled hormones metabolism were calculated. The T4 metabolic clearance (MCI) as well as the distribution space, were increased by 6 fold. Decreased serum T4 levels result from an increase both in deiodinative and fecal disposal in HCB-treated rats. 125I-T3 metabolism was slightly affected. The enhanced peripheral disposition of thyroxine appears to lead to increased thyroid function, as measured by augmented TSH serum levels and 125I-thyroidal uptake. Serum binding of T4 was not affected. © 1989, Italian Society of Endocrinology (SIE). All rights reserved.
format	JOUR
author	Kleiman de Pisarev, D.L. Sancovich, H.A. Ferramola de Sancovich, A.M.
author_facet	Kleiman de Pisarev, D.L. Sancovich, H.A. Ferramola de Sancovich, A.M.
author_sort	Kleiman de Pisarev, D.L.
title	Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats
title_short	Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats
title_full	Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats
title_fullStr	Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats
title_full_unstemmed	Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats
title_sort	enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats
url	http://hdl.handle.net/20.500.12110/paper_03914097_v12_n11_p767_KleimandePisarev
work_keys_str_mv	AT kleimandepisarevdl enhancedthyroxinemetabolisminhexachlorobenzeneintoxicatedrats AT sancovichha enhancedthyroxinemetabolisminhexachlorobenzeneintoxicatedrats AT ferramoladesancovicham enhancedthyroxinemetabolisminhexachlorobenzeneintoxicatedrats
_version_	1807321104755195904

Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats

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