Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes

Novel interpolyelectrolyte complexes (IPECs) between naturally sulfated polysaccharides of the seaweed Polysiphonia nigrescens (PN) and cationized agaroses (CAG) and Eudragit E (EE) were prepared using an organic solvent free process, characterized, and explored for controlled drug release. Tablets...

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Autores principales:	Prado, H.J., Matulewicz, M.C., Bonelli, P.R., Cukierman, A.L.
Formato:	JOUR
Materias:	Cationized agarose Controlled drug release Eudragit E Interpolyelectrolyte complexes (IPECs) Polysiphonia nigrescens agarose eudragit eudragit rs ibuprofen organic solvent article drug release molecular weight nonhuman priority journal seaweed solubility tablet Delayed-Action Preparations Diffusion Drug Compounding Electrolytes Excipients Ibuprofen Molecular Weight Polymers Polymethacrylic Acids Polysaccharides Seaweed Sepharose Solubility Tablets
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03785173_v429_n1-2_p12_Prado
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03785173_v429_n1-2_p12_Prado
record_format	dspace
spelling	todo:paper_03785173_v429_n1-2_p12_Prado2023-10-03T15:33:09Z Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes Prado, H.J. Matulewicz, M.C. Bonelli, P.R. Cukierman, A.L. Cationized agarose Controlled drug release Eudragit E Interpolyelectrolyte complexes (IPECs) Polysiphonia nigrescens agarose eudragit eudragit rs ibuprofen organic solvent article drug release molecular weight nonhuman priority journal seaweed solubility tablet Delayed-Action Preparations Diffusion Drug Compounding Electrolytes Excipients Ibuprofen Molecular Weight Polymers Polymethacrylic Acids Polysaccharides Seaweed Sepharose Solubility Tablets Novel interpolyelectrolyte complexes (IPECs) between naturally sulfated polysaccharides of the seaweed Polysiphonia nigrescens (PN) and cationized agaroses (CAG) and Eudragit E (EE) were prepared using an organic solvent free process, characterized, and explored for controlled drug release. Tablets containing model drug ibuprofen and IPECs were prepared by direct compression. Drug release in acid medium was low owing to the low solubility of ibuprofen in that condition and to the matrix action. Zero order drug release was determined in the buffer stage (pH = 6.8), with Fickian diffusion predominating over relaxation during the initial phases. Relaxation appears to increase along the release process and even overcomes diffusion for some systems. Drug release profiles could be controlled by varying the content of IPECs in the tablets. Also, the change in molecular weight and the degree of substitution of the components allowed altering the release profiles. © 2012 Elsevier B.V. Fil:Prado, H.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Matulewicz, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bonelli, P.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cukierman, A.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03785173_v429_n1-2_p12_Prado
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cationized agarose Controlled drug release Eudragit E Interpolyelectrolyte complexes (IPECs) Polysiphonia nigrescens agarose eudragit eudragit rs ibuprofen organic solvent article drug release molecular weight nonhuman priority journal seaweed solubility tablet Delayed-Action Preparations Diffusion Drug Compounding Electrolytes Excipients Ibuprofen Molecular Weight Polymers Polymethacrylic Acids Polysaccharides Seaweed Sepharose Solubility Tablets
spellingShingle	Cationized agarose Controlled drug release Eudragit E Interpolyelectrolyte complexes (IPECs) Polysiphonia nigrescens agarose eudragit eudragit rs ibuprofen organic solvent article drug release molecular weight nonhuman priority journal seaweed solubility tablet Delayed-Action Preparations Diffusion Drug Compounding Electrolytes Excipients Ibuprofen Molecular Weight Polymers Polymethacrylic Acids Polysaccharides Seaweed Sepharose Solubility Tablets Prado, H.J. Matulewicz, M.C. Bonelli, P.R. Cukierman, A.L. Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes
topic_facet	Cationized agarose Controlled drug release Eudragit E Interpolyelectrolyte complexes (IPECs) Polysiphonia nigrescens agarose eudragit eudragit rs ibuprofen organic solvent article drug release molecular weight nonhuman priority journal seaweed solubility tablet Delayed-Action Preparations Diffusion Drug Compounding Electrolytes Excipients Ibuprofen Molecular Weight Polymers Polymethacrylic Acids Polysaccharides Seaweed Sepharose Solubility Tablets
description	Novel interpolyelectrolyte complexes (IPECs) between naturally sulfated polysaccharides of the seaweed Polysiphonia nigrescens (PN) and cationized agaroses (CAG) and Eudragit E (EE) were prepared using an organic solvent free process, characterized, and explored for controlled drug release. Tablets containing model drug ibuprofen and IPECs were prepared by direct compression. Drug release in acid medium was low owing to the low solubility of ibuprofen in that condition and to the matrix action. Zero order drug release was determined in the buffer stage (pH = 6.8), with Fickian diffusion predominating over relaxation during the initial phases. Relaxation appears to increase along the release process and even overcomes diffusion for some systems. Drug release profiles could be controlled by varying the content of IPECs in the tablets. Also, the change in molecular weight and the degree of substitution of the components allowed altering the release profiles. © 2012 Elsevier B.V.
format	JOUR
author	Prado, H.J. Matulewicz, M.C. Bonelli, P.R. Cukierman, A.L.
author_facet	Prado, H.J. Matulewicz, M.C. Bonelli, P.R. Cukierman, A.L.
author_sort	Prado, H.J.
title	Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes
title_short	Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes
title_full	Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes
title_fullStr	Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes
title_full_unstemmed	Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes
title_sort	preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes
url	http://hdl.handle.net/20.500.12110/paper_03785173_v429_n1-2_p12_Prado
work_keys_str_mv	AT pradohj preparationandcharacterizationofcontrolledreleasematricesbasedonnovelseaweedinterpolyelectrolytecomplexes AT matulewiczmc preparationandcharacterizationofcontrolledreleasematricesbasedonnovelseaweedinterpolyelectrolytecomplexes AT bonellipr preparationandcharacterizationofcontrolledreleasematricesbasedonnovelseaweedinterpolyelectrolytecomplexes AT cukiermanal preparationandcharacterizationofcontrolledreleasematricesbasedonnovelseaweedinterpolyelectrolytecomplexes
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Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes

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