Cellular elements of the blood-brain barrier

The Blood-brain-barrier (BBB) provides both anatomical and physiological protection for the central nervous system (CNS), shielding the brain for toxic substances in the blood, supplying brain tissues with nutrients and filtering harmful compounds from the brain back to the bloodstream. The BBB is c...

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Autores principales:	Correale, J., Villa, A.
Formato:	JOUR
Materias:	Astrocytes Basement membrane matrix Blood brain barrier Endothelial cells Perycites Transport CD31 antigen claudin occludin vascular endothelial cadherin active transport astrocyte blood brain barrier central nervous system effusion endocytosis endothelium cell human ion transport microglia nonhuman priority journal review tight junction vascular endothelium Adherens Junctions Animals Blood-Brain Barrier Carrier Proteins Claudins Endothelial Cells Humans Membrane Proteins Microglia Pericytes Tight Junctions
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03643190_v34_n12_p2067_Correale
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03643190_v34_n12_p2067_Correale
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spelling	todo:paper_03643190_v34_n12_p2067_Correale2023-10-03T15:27:38Z Cellular elements of the blood-brain barrier Correale, J. Villa, A. Astrocytes Basement membrane matrix Blood brain barrier Endothelial cells Perycites Transport CD31 antigen claudin occludin vascular endothelial cadherin active transport astrocyte blood brain barrier central nervous system effusion endocytosis endothelium cell human ion transport microglia nonhuman priority journal review tight junction vascular endothelium Adherens Junctions Animals Astrocytes Blood-Brain Barrier Carrier Proteins Claudins Endothelial Cells Humans Membrane Proteins Microglia Pericytes Tight Junctions The Blood-brain-barrier (BBB) provides both anatomical and physiological protection for the central nervous system (CNS), shielding the brain for toxic substances in the blood, supplying brain tissues with nutrients and filtering harmful compounds from the brain back to the bloodstream. The BBB is composed of four main cellular elements: endothelial cells (ECs), astrocyte end-feet, microglial cells, and perycites. Transport across the BBB is limited by both physical and metabolic barriers (enzymes, and different transport systems). Tight junctions (TJs) present between ECs form an important barrier against diffusion, excluding most blood-borne substances for entering the brain. © 2009 Springer Science+Business Media, LLC. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03643190_v34_n12_p2067_Correale
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Astrocytes Basement membrane matrix Blood brain barrier Endothelial cells Perycites Transport CD31 antigen claudin occludin vascular endothelial cadherin active transport astrocyte blood brain barrier central nervous system effusion endocytosis endothelium cell human ion transport microglia nonhuman priority journal review tight junction vascular endothelium Adherens Junctions Animals Astrocytes Blood-Brain Barrier Carrier Proteins Claudins Endothelial Cells Humans Membrane Proteins Microglia Pericytes Tight Junctions
spellingShingle	Astrocytes Basement membrane matrix Blood brain barrier Endothelial cells Perycites Transport CD31 antigen claudin occludin vascular endothelial cadherin active transport astrocyte blood brain barrier central nervous system effusion endocytosis endothelium cell human ion transport microglia nonhuman priority journal review tight junction vascular endothelium Adherens Junctions Animals Astrocytes Blood-Brain Barrier Carrier Proteins Claudins Endothelial Cells Humans Membrane Proteins Microglia Pericytes Tight Junctions Correale, J. Villa, A. Cellular elements of the blood-brain barrier
topic_facet	Astrocytes Basement membrane matrix Blood brain barrier Endothelial cells Perycites Transport CD31 antigen claudin occludin vascular endothelial cadherin active transport astrocyte blood brain barrier central nervous system effusion endocytosis endothelium cell human ion transport microglia nonhuman priority journal review tight junction vascular endothelium Adherens Junctions Animals Astrocytes Blood-Brain Barrier Carrier Proteins Claudins Endothelial Cells Humans Membrane Proteins Microglia Pericytes Tight Junctions
description	The Blood-brain-barrier (BBB) provides both anatomical and physiological protection for the central nervous system (CNS), shielding the brain for toxic substances in the blood, supplying brain tissues with nutrients and filtering harmful compounds from the brain back to the bloodstream. The BBB is composed of four main cellular elements: endothelial cells (ECs), astrocyte end-feet, microglial cells, and perycites. Transport across the BBB is limited by both physical and metabolic barriers (enzymes, and different transport systems). Tight junctions (TJs) present between ECs form an important barrier against diffusion, excluding most blood-borne substances for entering the brain. © 2009 Springer Science+Business Media, LLC.
format	JOUR
author	Correale, J. Villa, A.
author_facet	Correale, J. Villa, A.
author_sort	Correale, J.
title	Cellular elements of the blood-brain barrier
title_short	Cellular elements of the blood-brain barrier
title_full	Cellular elements of the blood-brain barrier
title_fullStr	Cellular elements of the blood-brain barrier
title_full_unstemmed	Cellular elements of the blood-brain barrier
title_sort	cellular elements of the blood-brain barrier
url	http://hdl.handle.net/20.500.12110/paper_03643190_v34_n12_p2067_Correale
work_keys_str_mv	AT correalej cellularelementsofthebloodbrainbarrier AT villaa cellularelementsofthebloodbrainbarrier
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Cellular elements of the blood-brain barrier

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