Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes

Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligo-dendrocyte cell sha...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Thomas, M.G., Santa Coloma, T.A., Correale, J., Boccaccio, G.L.
Formato: JOUR
Materias:
rat
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03643190_v27_n11_p1305_Thomas
Aporte de:
id todo:paper_03643190_v27_n11_p1305_Thomas
record_format dspace
spelling todo:paper_03643190_v27_n11_p1305_Thomas2023-10-03T15:27:37Z Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes Thomas, M.G. Santa Coloma, T.A. Correale, J. Boccaccio, G.L. ML-7 ML-9 MLCK Myelin Myosin II Oligodendrocyte processes myosin IIA myosin light chain kinase inhibitor protein ml 7 protein ml 9 unclassified drug animal tissue article cell activity cell adhesion cell culture cell differentiation cell growth cell maturation cell shape central nervous system controlled study immunohistochemistry myelination nonhuman oligodendroglia phosphorylation priority journal rat Animals Azepines Enzyme Inhibitors Myosin-Light-Chain Kinase Naphthalenes Oligodendroglia Phosphorylation Rats Rats, Wistar Animalia Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligo-dendrocyte cell shape, provoking a retraction of high order processes. Our results suggest that the adhesion of the myelinating processes to the substrate depends on MLC phosphorylation, thus likely implicating myosin IIA. Fil:Thomas, M.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Santa Coloma, T.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Boccaccio, G.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03643190_v27_n11_p1305_Thomas
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic ML-7
ML-9
MLCK
Myelin
Myosin II
Oligodendrocyte processes
myosin IIA
myosin light chain kinase inhibitor
protein ml 7
protein ml 9
unclassified drug
animal tissue
article
cell activity
cell adhesion
cell culture
cell differentiation
cell growth
cell maturation
cell shape
central nervous system
controlled study
immunohistochemistry
myelination
nonhuman
oligodendroglia
phosphorylation
priority journal
rat
Animals
Azepines
Enzyme Inhibitors
Myosin-Light-Chain Kinase
Naphthalenes
Oligodendroglia
Phosphorylation
Rats
Rats, Wistar
Animalia
spellingShingle ML-7
ML-9
MLCK
Myelin
Myosin II
Oligodendrocyte processes
myosin IIA
myosin light chain kinase inhibitor
protein ml 7
protein ml 9
unclassified drug
animal tissue
article
cell activity
cell adhesion
cell culture
cell differentiation
cell growth
cell maturation
cell shape
central nervous system
controlled study
immunohistochemistry
myelination
nonhuman
oligodendroglia
phosphorylation
priority journal
rat
Animals
Azepines
Enzyme Inhibitors
Myosin-Light-Chain Kinase
Naphthalenes
Oligodendroglia
Phosphorylation
Rats
Rats, Wistar
Animalia
Thomas, M.G.
Santa Coloma, T.A.
Correale, J.
Boccaccio, G.L.
Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
topic_facet ML-7
ML-9
MLCK
Myelin
Myosin II
Oligodendrocyte processes
myosin IIA
myosin light chain kinase inhibitor
protein ml 7
protein ml 9
unclassified drug
animal tissue
article
cell activity
cell adhesion
cell culture
cell differentiation
cell growth
cell maturation
cell shape
central nervous system
controlled study
immunohistochemistry
myelination
nonhuman
oligodendroglia
phosphorylation
priority journal
rat
Animals
Azepines
Enzyme Inhibitors
Myosin-Light-Chain Kinase
Naphthalenes
Oligodendroglia
Phosphorylation
Rats
Rats, Wistar
Animalia
description Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligo-dendrocyte cell shape, provoking a retraction of high order processes. Our results suggest that the adhesion of the myelinating processes to the substrate depends on MLC phosphorylation, thus likely implicating myosin IIA.
format JOUR
author Thomas, M.G.
Santa Coloma, T.A.
Correale, J.
Boccaccio, G.L.
author_facet Thomas, M.G.
Santa Coloma, T.A.
Correale, J.
Boccaccio, G.L.
author_sort Thomas, M.G.
title Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
title_short Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
title_full Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
title_fullStr Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
title_full_unstemmed Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
title_sort myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
url http://hdl.handle.net/20.500.12110/paper_03643190_v27_n11_p1305_Thomas
work_keys_str_mv AT thomasmg myosinlightchainkinaseinhibitorsinduceretractionofmatureoligodendrocyteprocesses
AT santacolomata myosinlightchainkinaseinhibitorsinduceretractionofmatureoligodendrocyteprocesses
AT correalej myosinlightchainkinaseinhibitorsinduceretractionofmatureoligodendrocyteprocesses
AT boccacciogl myosinlightchainkinaseinhibitorsinduceretractionofmatureoligodendrocyteprocesses
_version_ 1782028622457995264