Synthesis of 131I derivatives of indolealkylamines for brain mapping

The synthesis and spectral properties of new radioiodinated indolealkylamines like 2-[131 I]-iodo-N,N-dimethyltryptamine, 2-[131 I]-iodo-N-methyltryptamine, 2-[131 I]-iodo-5-methoxy-N,N-dimethyltryptamine, 2-[131 I]-iodo-5-hydroxy-N,N-dimethyltryptamine (2-[131 I]-iodo-bufotenine), and 2-[131I]-iodo...

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Detalles Bibliográficos
Autores principales: Sintas, J.A., Vitale, A.A.
Formato: JOUR
Materias:
2-[131I]-iodo-5-hydroxy-N,N-dimethyltryptamine
2-[131I]-iodo-5-methoxy-N,N-dimethyltryptamine
2-[131I]-iodo-N,N-dimethyltryptamine
2-[131I]-iodo-N-methyltryptamine
2-[131I]-iodo-tryptamine
2-[131I]-melatonine
indoleamine
iodine 131
tryptamine derivative
article
brain mapping
drug purity
drug synthesis
in vitro study
iodination
mass spectrometry
nuclear magnetic resonance spectroscopy
radiochemistry
radioiodination
reaction analysis
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03624803_v39_n8_p677_Sintas
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The synthesis and spectral properties of new radioiodinated indolealkylamines like 2-[131 I]-iodo-N,N-dimethyltryptamine, 2-[131 I]-iodo-N-methyltryptamine, 2-[131 I]-iodo-5-methoxy-N,N-dimethyltryptamine, 2-[131 I]-iodo-5-hydroxy-N,N-dimethyltryptamine (2-[131 I]-iodo-bufotenine), and 2-[131I]-iodo-tryptamine and the known 2-[131I]-iodo-N-acetyl-5-methoxy-tryptamine (2-[131I]-iodo-melatonine) are described herein. These were synthesized by a high-yield novel method, and their spectral properties are fully described. These compounds are of biological importance and can be used for brain mapping with SPECT technology.

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