Synthesis of 131I derivatives of indolealkylamines for brain mapping

The synthesis and spectral properties of new radioiodinated indolealkylamines like 2-[131 I]-iodo-N,N-dimethyltryptamine, 2-[131 I]-iodo-N-methyltryptamine, 2-[131 I]-iodo-5-methoxy-N,N-dimethyltryptamine, 2-[131 I]-iodo-5-hydroxy-N,N-dimethyltryptamine (2-[131 I]-iodo-bufotenine), and 2-[131I]-iodo...

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Autores principales:	Sintas, J.A., Vitale, A.A.
Formato:	JOUR
Materias:	2-[131I]-iodo-5-hydroxy-N,N-dimethyltryptamine 2-[131I]-iodo-5-methoxy-N,N-dimethyltryptamine 2-[131I]-iodo-N,N-dimethyltryptamine 2-[131I]-iodo-N-methyltryptamine 2-[131I]-iodo-tryptamine 2-[131I]-melatonine indoleamine iodine 131 tryptamine derivative article brain mapping drug purity drug synthesis in vitro study iodination mass spectrometry nuclear magnetic resonance spectroscopy radiochemistry radioiodination reaction analysis
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03624803_v39_n8_p677_Sintas
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03624803_v39_n8_p677_Sintas
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spelling	todo:paper_03624803_v39_n8_p677_Sintas2023-10-03T15:27:08Z Synthesis of 131I derivatives of indolealkylamines for brain mapping Sintas, J.A. Vitale, A.A. 2-[131I]-iodo-5-hydroxy-N,N-dimethyltryptamine 2-[131I]-iodo-5-methoxy-N,N-dimethyltryptamine 2-[131I]-iodo-N,N-dimethyltryptamine 2-[131I]-iodo-N-methyltryptamine 2-[131I]-iodo-tryptamine 2-[131I]-melatonine indoleamine iodine 131 tryptamine derivative article brain mapping drug purity drug synthesis in vitro study iodination mass spectrometry nuclear magnetic resonance spectroscopy radiochemistry radioiodination reaction analysis The synthesis and spectral properties of new radioiodinated indolealkylamines like 2-[131 I]-iodo-N,N-dimethyltryptamine, 2-[131 I]-iodo-N-methyltryptamine, 2-[131 I]-iodo-5-methoxy-N,N-dimethyltryptamine, 2-[131 I]-iodo-5-hydroxy-N,N-dimethyltryptamine (2-[131 I]-iodo-bufotenine), and 2-[131I]-iodo-tryptamine and the known 2-[131I]-iodo-N-acetyl-5-methoxy-tryptamine (2-[131I]-iodo-melatonine) are described herein. These were synthesized by a high-yield novel method, and their spectral properties are fully described. These compounds are of biological importance and can be used for brain mapping with SPECT technology. Fil:Vitale, A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03624803_v39_n8_p677_Sintas
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	2-[131I]-iodo-5-hydroxy-N,N-dimethyltryptamine 2-[131I]-iodo-5-methoxy-N,N-dimethyltryptamine 2-[131I]-iodo-N,N-dimethyltryptamine 2-[131I]-iodo-N-methyltryptamine 2-[131I]-iodo-tryptamine 2-[131I]-melatonine indoleamine iodine 131 tryptamine derivative article brain mapping drug purity drug synthesis in vitro study iodination mass spectrometry nuclear magnetic resonance spectroscopy radiochemistry radioiodination reaction analysis
spellingShingle	2-[131I]-iodo-5-hydroxy-N,N-dimethyltryptamine 2-[131I]-iodo-5-methoxy-N,N-dimethyltryptamine 2-[131I]-iodo-N,N-dimethyltryptamine 2-[131I]-iodo-N-methyltryptamine 2-[131I]-iodo-tryptamine 2-[131I]-melatonine indoleamine iodine 131 tryptamine derivative article brain mapping drug purity drug synthesis in vitro study iodination mass spectrometry nuclear magnetic resonance spectroscopy radiochemistry radioiodination reaction analysis Sintas, J.A. Vitale, A.A. Synthesis of 131I derivatives of indolealkylamines for brain mapping
topic_facet	2-[131I]-iodo-5-hydroxy-N,N-dimethyltryptamine 2-[131I]-iodo-5-methoxy-N,N-dimethyltryptamine 2-[131I]-iodo-N,N-dimethyltryptamine 2-[131I]-iodo-N-methyltryptamine 2-[131I]-iodo-tryptamine 2-[131I]-melatonine indoleamine iodine 131 tryptamine derivative article brain mapping drug purity drug synthesis in vitro study iodination mass spectrometry nuclear magnetic resonance spectroscopy radiochemistry radioiodination reaction analysis
description	The synthesis and spectral properties of new radioiodinated indolealkylamines like 2-[131 I]-iodo-N,N-dimethyltryptamine, 2-[131 I]-iodo-N-methyltryptamine, 2-[131 I]-iodo-5-methoxy-N,N-dimethyltryptamine, 2-[131 I]-iodo-5-hydroxy-N,N-dimethyltryptamine (2-[131 I]-iodo-bufotenine), and 2-[131I]-iodo-tryptamine and the known 2-[131I]-iodo-N-acetyl-5-methoxy-tryptamine (2-[131I]-iodo-melatonine) are described herein. These were synthesized by a high-yield novel method, and their spectral properties are fully described. These compounds are of biological importance and can be used for brain mapping with SPECT technology.
format	JOUR
author	Sintas, J.A. Vitale, A.A.
author_facet	Sintas, J.A. Vitale, A.A.
author_sort	Sintas, J.A.
title	Synthesis of 131I derivatives of indolealkylamines for brain mapping
title_short	Synthesis of 131I derivatives of indolealkylamines for brain mapping
title_full	Synthesis of 131I derivatives of indolealkylamines for brain mapping
title_fullStr	Synthesis of 131I derivatives of indolealkylamines for brain mapping
title_full_unstemmed	Synthesis of 131I derivatives of indolealkylamines for brain mapping
title_sort	synthesis of 131i derivatives of indolealkylamines for brain mapping
url	http://hdl.handle.net/20.500.12110/paper_03624803_v39_n8_p677_Sintas
work_keys_str_mv	AT sintasja synthesisof131iderivativesofindolealkylaminesforbrainmapping AT vitaleaa synthesisof131iderivativesofindolealkylaminesforbrainmapping
_version_	1807320131616899072

Synthesis of 131I derivatives of indolealkylamines for brain mapping

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