Morphine and GABA: Effects on perception, escape response and long-term habituation to a danger stimulus in the crab Chasmagnathus
Prior results (37) showed that morphine pretreatment reduces the escape response of the crab Chasmagnathus to a shadow passing overhead and prevents the acquisition of a long-term habituation. These results were explained by a reduction in the danger signalled by the stimulus, and to test this hypot...
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todo:paper_03619230_v26_n5_p699_Tomsic2023-10-03T15:26:45Z Morphine and GABA: Effects on perception, escape response and long-term habituation to a danger stimulus in the crab Chasmagnathus Tomsic, D. Maldonado, H. Rakitin, A. Crustacea Danger stimulus GABA Habituation Morphine Response-independent habituation 4 aminobutyric acid morphine animal experiment article controlled study crab habituation intracerebral drug administration nonhuman priority journal Animal Brachyura Escape Reaction gamma-Aminobutyric Acid Habituation (Psychophysiology) Injections Male Morphine Perception Pilot Projects Support, Non-U.S. Gov't Time Factors Prior results (37) showed that morphine pretreatment reduces the escape response of the crab Chasmagnathus to a shadow passing overhead and prevents the acquisition of a long-term habituation. These results were explained by a reduction in the danger signalled by the stimulus, and to test this hypothesis methods other than morphine injection were used herein to abolish response during training. GABA pretreatment induced a dose-dependent reduction in responsiveness to the danger stimulus, and instances of autotomy were shown with doses larger than 12 μg/g. A response was rarely displayed with a 9 μg GABA/g dose given 5 min before training, but long-term memory was acquired. In one experiment, both morphine and GABA pretreatment produced similar mild response inhibition during training, but morphine, not GABA impaired long-term habituation. Morphine administered immediately after training had no amnesic effect. These results support the hypothesis that morphine effects may be explained by transient disruption between the stimulus and its danger meaning, ruling out alternative explanations such as response inhibition or amnesia due to either storage or retrieval failure. © 1991. Fil:Tomsic, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03619230_v26_n5_p699_Tomsic |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Crustacea Danger stimulus GABA Habituation Morphine Response-independent habituation 4 aminobutyric acid morphine animal experiment article controlled study crab habituation intracerebral drug administration nonhuman priority journal Animal Brachyura Escape Reaction gamma-Aminobutyric Acid Habituation (Psychophysiology) Injections Male Morphine Perception Pilot Projects Support, Non-U.S. Gov't Time Factors |
| spellingShingle |
Crustacea Danger stimulus GABA Habituation Morphine Response-independent habituation 4 aminobutyric acid morphine animal experiment article controlled study crab habituation intracerebral drug administration nonhuman priority journal Animal Brachyura Escape Reaction gamma-Aminobutyric Acid Habituation (Psychophysiology) Injections Male Morphine Perception Pilot Projects Support, Non-U.S. Gov't Time Factors Tomsic, D. Maldonado, H. Rakitin, A. Morphine and GABA: Effects on perception, escape response and long-term habituation to a danger stimulus in the crab Chasmagnathus |
| topic_facet |
Crustacea Danger stimulus GABA Habituation Morphine Response-independent habituation 4 aminobutyric acid morphine animal experiment article controlled study crab habituation intracerebral drug administration nonhuman priority journal Animal Brachyura Escape Reaction gamma-Aminobutyric Acid Habituation (Psychophysiology) Injections Male Morphine Perception Pilot Projects Support, Non-U.S. Gov't Time Factors |
| description |
Prior results (37) showed that morphine pretreatment reduces the escape response of the crab Chasmagnathus to a shadow passing overhead and prevents the acquisition of a long-term habituation. These results were explained by a reduction in the danger signalled by the stimulus, and to test this hypothesis methods other than morphine injection were used herein to abolish response during training. GABA pretreatment induced a dose-dependent reduction in responsiveness to the danger stimulus, and instances of autotomy were shown with doses larger than 12 μg/g. A response was rarely displayed with a 9 μg GABA/g dose given 5 min before training, but long-term memory was acquired. In one experiment, both morphine and GABA pretreatment produced similar mild response inhibition during training, but morphine, not GABA impaired long-term habituation. Morphine administered immediately after training had no amnesic effect. These results support the hypothesis that morphine effects may be explained by transient disruption between the stimulus and its danger meaning, ruling out alternative explanations such as response inhibition or amnesia due to either storage or retrieval failure. © 1991. |
| format |
JOUR |
| author |
Tomsic, D. Maldonado, H. Rakitin, A. |
| author_facet |
Tomsic, D. Maldonado, H. Rakitin, A. |
| author_sort |
Tomsic, D. |
| title |
Morphine and GABA: Effects on perception, escape response and long-term habituation to a danger stimulus in the crab Chasmagnathus |
| title_short |
Morphine and GABA: Effects on perception, escape response and long-term habituation to a danger stimulus in the crab Chasmagnathus |
| title_full |
Morphine and GABA: Effects on perception, escape response and long-term habituation to a danger stimulus in the crab Chasmagnathus |
| title_fullStr |
Morphine and GABA: Effects on perception, escape response and long-term habituation to a danger stimulus in the crab Chasmagnathus |
| title_full_unstemmed |
Morphine and GABA: Effects on perception, escape response and long-term habituation to a danger stimulus in the crab Chasmagnathus |
| title_sort |
morphine and gaba: effects on perception, escape response and long-term habituation to a danger stimulus in the crab chasmagnathus |
| url |
http://hdl.handle.net/20.500.12110/paper_03619230_v26_n5_p699_Tomsic |
| work_keys_str_mv |
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