Induction and Rejoining of DNA Double Strand Breaks Assessed by H2AX Phosphorylation in Melanoma Cells Irradiated with Proton and Lithium Beams

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Purpose: The aim of this study was to evaluate the induction and rejoining of DNA double strand breaks (DSBs) in melanoma cells exposed to low and high linear energy transfer (LET) radiation. Methods and Materials: DSBs and survival were determined as a function of dose in melanoma cells (B16-F0) ir...

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Detalles Bibliográficos
Autores principales: Ibañez, I.L., Bracalente, C., Molinari, B.L., Palmieri, M.A., Policastro, L., Kreiner, A.J., Burlón, A.A., Valda, A., Navalesi, D., Davidson, J., Davidson, M., Vázquez, M., Ozafrán, M., Durán, H.
Formato: JOUR
Materias:
γH2AX
DNA DSB
Ionizing radiation
LET
Melanoma cells
Clonogenic assays
DNA double strand breaks
Gamma source
High linear energy transfers
In-cell
LET radiation
Linear-quadratic models
Low-LET radiation
Monoenergetic protons
Phosphorylated histone
Postirradiation
Survival curves
Surviving fractions
Cell membranes
DNA
Energy transfer
Genes
Lithium
Nucleic acids
Phosphorylation
Proton irradiation
Protons
Radiation shielding
Radioactivity
Lighting fixtures
double stranded DNA
histone H2AX
animal cell
article
cancer cell culture
cancer radiotherapy
cancer survival
clonogenic assay
DNA determination
DNA strand breakage
linear energy transfer
low energy radiation
melanoma
melanoma cell
mouse
nonhuman
priority journal
protein determination
protein phosphorylation
proton radiation
radiation dose
Biological Markers
Cell Survival
DNA Breaks, Double-Stranded
DNA Repair
Dose-Response Relationship, Radiation
Histones
Humans
Linear Energy Transfer
Melanoma, Experimental
Radiation Tolerance
Radioisotopes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03603016_v74_n4_p1226_Ibanez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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