Susceptibility to β-lactams in β-hemolytic streptococci

Group A (GAS), B (GBS), C (GCS) and G (GGS) β-hemolytic streptococci are important human pathogens. They cause infections of different severity and frequency. Nowadays, after 70 years of use, penicillin is still universally active against GAS, GCS and GGS. However, therapeutic failures have been rec...

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Autores principales: Bonofiglio, L., Gagetti, P., García Gabarrot, G., Kaufman, S., Mollerach, M., Toresani, I., Vigliarolo, L., von Specht, M., Lopardo, H.A.
Formato: INPR
Materias:
Penicillin
Streptococcus agalactiae
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus pyogenes
Susceptibility
β-Lactams
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03257541_v_n_p_Bonofiglio
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_03257541_v_n_p_Bonofiglio
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spelling todo:paper_03257541_v_n_p_Bonofiglio2023-10-03T15:24:24Z Susceptibility to β-lactams in β-hemolytic streptococci Bonofiglio, L. Gagetti, P. García Gabarrot, G. Kaufman, S. Mollerach, M. Toresani, I. Vigliarolo, L. von Specht, M. Lopardo, H.A. Penicillin Streptococcus agalactiae Streptococcus dysgalactiae subsp. equisimilis Streptococcus pyogenes Susceptibility β-Lactams Group A (GAS), B (GBS), C (GCS) and G (GGS) β-hemolytic streptococci are important human pathogens. They cause infections of different severity and frequency. Nowadays, after 70 years of use, penicillin is still universally active against GAS, GCS and GGS. However, therapeutic failures have been recorded in 2-28% of pharyngitis cases (median: 12%) attributable to different causes. By contrast, some GBS with reduced susceptibility to penicillin have been described, especially in Japan. In this group of bacteria, it is important to highlight that confirmation by reference methods is mandatory when decreased susceptibility to penicillin is suspected as well as checked for the detection of the mechanisms involved. Los estreptococos β-hemolíticos de los grupos A (GAS), B (GBS), C (GCS) y G (GGS) son importantes patógenos humanos. Ellos producen infecciones de diversa gravedad y frecuencia. Aún después de más de 70 años de uso, la penicilina sigue siendo activa in vitro frente al 100% de los GAS, GCS y GGS. No obstante se han producido fallas terapéuticas entre el 2-28% de los casos de faringitis (media: 12%), atribuibles a diversas causas. En cambio se han descrito aislados de GBS con sensibilidad reducida a la penicilina, especialmente en Japón. Es importante que toda sospecha de sensibilidad disminuida a la penicilina en este grupo de bacterias sea confirmada por los métodos de referencia y comprobada mediante la detección de los mecanismos involucrados. © 2017 Asociación Argentina de Microbiología. INPR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03257541_v_n_p_Bonofiglio
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Penicillin
Streptococcus agalactiae
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus pyogenes
Susceptibility
β-Lactams
spellingShingle Penicillin
Streptococcus agalactiae
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus pyogenes
Susceptibility
β-Lactams
Bonofiglio, L.
Gagetti, P.
García Gabarrot, G.
Kaufman, S.
Mollerach, M.
Toresani, I.
Vigliarolo, L.
von Specht, M.
Lopardo, H.A.
Susceptibility to β-lactams in β-hemolytic streptococci
topic_facet Penicillin
Streptococcus agalactiae
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus pyogenes
Susceptibility
β-Lactams
description Group A (GAS), B (GBS), C (GCS) and G (GGS) β-hemolytic streptococci are important human pathogens. They cause infections of different severity and frequency. Nowadays, after 70 years of use, penicillin is still universally active against GAS, GCS and GGS. However, therapeutic failures have been recorded in 2-28% of pharyngitis cases (median: 12%) attributable to different causes. By contrast, some GBS with reduced susceptibility to penicillin have been described, especially in Japan. In this group of bacteria, it is important to highlight that confirmation by reference methods is mandatory when decreased susceptibility to penicillin is suspected as well as checked for the detection of the mechanisms involved. Los estreptococos β-hemolíticos de los grupos A (GAS), B (GBS), C (GCS) y G (GGS) son importantes patógenos humanos. Ellos producen infecciones de diversa gravedad y frecuencia. Aún después de más de 70 años de uso, la penicilina sigue siendo activa in vitro frente al 100% de los GAS, GCS y GGS. No obstante se han producido fallas terapéuticas entre el 2-28% de los casos de faringitis (media: 12%), atribuibles a diversas causas. En cambio se han descrito aislados de GBS con sensibilidad reducida a la penicilina, especialmente en Japón. Es importante que toda sospecha de sensibilidad disminuida a la penicilina en este grupo de bacterias sea confirmada por los métodos de referencia y comprobada mediante la detección de los mecanismos involucrados. © 2017 Asociación Argentina de Microbiología.
format INPR
author Bonofiglio, L.
Gagetti, P.
García Gabarrot, G.
Kaufman, S.
Mollerach, M.
Toresani, I.
Vigliarolo, L.
von Specht, M.
Lopardo, H.A.
author_facet Bonofiglio, L.
Gagetti, P.
García Gabarrot, G.
Kaufman, S.
Mollerach, M.
Toresani, I.
Vigliarolo, L.
von Specht, M.
Lopardo, H.A.
author_sort Bonofiglio, L.
title Susceptibility to β-lactams in β-hemolytic streptococci
title_short Susceptibility to β-lactams in β-hemolytic streptococci
title_full Susceptibility to β-lactams in β-hemolytic streptococci
title_fullStr Susceptibility to β-lactams in β-hemolytic streptococci
title_full_unstemmed Susceptibility to β-lactams in β-hemolytic streptococci
title_sort susceptibility to β-lactams in β-hemolytic streptococci
url http://hdl.handle.net/20.500.12110/paper_03257541_v_n_p_Bonofiglio
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