N-homocysteinylation reactions related to hyperhomocysteinemia

Increased plasma homocysteine levels (hyperhomocysteinemia) are associated with occlusive vascular diseases, such as atherosclerosis and thrombosis. Reduced homocysteine (Hcy) and its cyclic ester, homocysteine thiolactone (HTL) would be involved in the detrimental effects associated to hyperhomocys...

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Autores principales:	Genoud, V., Quintana, I.
Formato:	JOUR
Materias:	Homocysteine-thiolactone Hyperhomocysteinemia N-homocysteinylation Occlusive vascular disease
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03252957_v50_n4_p679_Genoud
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_03252957_v50_n4_p679_Genoud2023-10-03T15:23:45Z N-homocysteinylation reactions related to hyperhomocysteinemia Genoud, V. Quintana, I. Homocysteine-thiolactone Hyperhomocysteinemia N-homocysteinylation Occlusive vascular disease Increased plasma homocysteine levels (hyperhomocysteinemia) are associated with occlusive vascular diseases, such as atherosclerosis and thrombosis. Reduced homocysteine (Hcy) and its cyclic ester, homocysteine thiolactone (HTL) would be involved in the detrimental effects associated to hyperhomocysteinemia. These two species, Hcy and HTL can spontaneously react with proteins, through S and N-homocysteinylation process, respectively. Both reactions produce post-translational protein changes, impairing structural and functional features. In recent years, interest has been developed in HTL and its effects on human health. N-homocysteinylation is the reaction between the carboxyl group of HTL and ϵ-amino group of lysine residues, rendering free sulfhydryl groups able to participate in redox reactions. N-homocysteinylated proteins are prone to misfolding and oxidative damage, inducing cytotoxic and immunogenic effects. Metabolic conversion of Hcy to HTL as well as protein N-homocysteinylation is one of the mechanisms underlying the development of pathologies associated to hyperhomocysteinemia, such as cardiovascular and neurodegenerative diseases. Fil:Quintana, I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03252957_v50_n4_p679_Genoud
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Homocysteine-thiolactone Hyperhomocysteinemia N-homocysteinylation Occlusive vascular disease
spellingShingle	Homocysteine-thiolactone Hyperhomocysteinemia N-homocysteinylation Occlusive vascular disease Genoud, V. Quintana, I. N-homocysteinylation reactions related to hyperhomocysteinemia
topic_facet	Homocysteine-thiolactone Hyperhomocysteinemia N-homocysteinylation Occlusive vascular disease
description	Increased plasma homocysteine levels (hyperhomocysteinemia) are associated with occlusive vascular diseases, such as atherosclerosis and thrombosis. Reduced homocysteine (Hcy) and its cyclic ester, homocysteine thiolactone (HTL) would be involved in the detrimental effects associated to hyperhomocysteinemia. These two species, Hcy and HTL can spontaneously react with proteins, through S and N-homocysteinylation process, respectively. Both reactions produce post-translational protein changes, impairing structural and functional features. In recent years, interest has been developed in HTL and its effects on human health. N-homocysteinylation is the reaction between the carboxyl group of HTL and ϵ-amino group of lysine residues, rendering free sulfhydryl groups able to participate in redox reactions. N-homocysteinylated proteins are prone to misfolding and oxidative damage, inducing cytotoxic and immunogenic effects. Metabolic conversion of Hcy to HTL as well as protein N-homocysteinylation is one of the mechanisms underlying the development of pathologies associated to hyperhomocysteinemia, such as cardiovascular and neurodegenerative diseases.
format	JOUR
author	Genoud, V. Quintana, I.
author_facet	Genoud, V. Quintana, I.
author_sort	Genoud, V.
title	N-homocysteinylation reactions related to hyperhomocysteinemia
title_short	N-homocysteinylation reactions related to hyperhomocysteinemia
title_full	N-homocysteinylation reactions related to hyperhomocysteinemia
title_fullStr	N-homocysteinylation reactions related to hyperhomocysteinemia
title_full_unstemmed	N-homocysteinylation reactions related to hyperhomocysteinemia
title_sort	n-homocysteinylation reactions related to hyperhomocysteinemia
url	http://hdl.handle.net/20.500.12110/paper_03252957_v50_n4_p679_Genoud
work_keys_str_mv	AT genoudv nhomocysteinylationreactionsrelatedtohyperhomocysteinemia AT quintanai nhomocysteinylationreactionsrelatedtohyperhomocysteinemia
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N-homocysteinylation reactions related to hyperhomocysteinemia

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