Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients
Endothelial dysfunction has been defined as an imbalance between relaxing and contracting factors and has been implicated in the pathophysiology of several cardiovascular disorders, hypertension and diabetes. Plasmatic levels of endothelin-1, nitric oxide, von Willebrand factor, fibrinogen, glycated...
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todo:paper_03252957_v38_n4_p471_Ouvina2023-10-03T15:23:36Z Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients Ouviña, S.M. Palmer, L. Sassetti, B. Endothelial dysfunction Endothelin-1 Nitric oxide Type 2 diabetes Von Willebrand factor endothelin 1 fibrinogen nitric oxide von Willebrand factor adult aged article bioavailability blood pressure monitoring body mass cardiovascular disease clinical article controlled study correlation analysis data analysis diet endothelium lesion female glucose blood level glycation hemoconcentration hemoglobin determination human hypertension inflammation insulin resistance insulinemia intermethod comparison lipid analysis male non insulin dependent diabetes mellitus pathophysiology sex difference smoking statistical significance thrombosis Endothelial dysfunction has been defined as an imbalance between relaxing and contracting factors and has been implicated in the pathophysiology of several cardiovascular disorders, hypertension and diabetes. Plasmatic levels of endothelin-1, nitric oxide, von Willebrand factor, fibrinogen, glycated haemoglobin, glycaemia, Insulinaemia, lipid profile and blood pressure in 30 hypertensive and type II diabetic patients and 25 healthy subjects matched in age, sex, body mass index and smoking and dietary habits, were evaluated in order to study the relationship among these variables in the diabetic prothrombotic state. Endothelin-1, nitric oxide, von Willebrand factor and fibrinogen levels were higher in patients than in controls (p < 0.05). There was a significant positive correlation between nitric oxide and insulinaemia (p < 0.05) and between nitric oxide and von Willebrand factor (p < 0.05) in the group of patients. These data suggest that the prothrombotic state in these patients could be determined by the increased levels of endothelin-1, the high but less bioavailable nitric oxide values, the endothelial damage and inflammatory state reflected by high von Willebrand factor and fibrinogen levels associated with dyslipidemia and the insulin-resistance state. Fil:Ouviña, S.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sassetti, B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03252957_v38_n4_p471_Ouvina |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Endothelial dysfunction Endothelin-1 Nitric oxide Type 2 diabetes Von Willebrand factor endothelin 1 fibrinogen nitric oxide von Willebrand factor adult aged article bioavailability blood pressure monitoring body mass cardiovascular disease clinical article controlled study correlation analysis data analysis diet endothelium lesion female glucose blood level glycation hemoconcentration hemoglobin determination human hypertension inflammation insulin resistance insulinemia intermethod comparison lipid analysis male non insulin dependent diabetes mellitus pathophysiology sex difference smoking statistical significance thrombosis |
| spellingShingle |
Endothelial dysfunction Endothelin-1 Nitric oxide Type 2 diabetes Von Willebrand factor endothelin 1 fibrinogen nitric oxide von Willebrand factor adult aged article bioavailability blood pressure monitoring body mass cardiovascular disease clinical article controlled study correlation analysis data analysis diet endothelium lesion female glucose blood level glycation hemoconcentration hemoglobin determination human hypertension inflammation insulin resistance insulinemia intermethod comparison lipid analysis male non insulin dependent diabetes mellitus pathophysiology sex difference smoking statistical significance thrombosis Ouviña, S.M. Palmer, L. Sassetti, B. Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients |
| topic_facet |
Endothelial dysfunction Endothelin-1 Nitric oxide Type 2 diabetes Von Willebrand factor endothelin 1 fibrinogen nitric oxide von Willebrand factor adult aged article bioavailability blood pressure monitoring body mass cardiovascular disease clinical article controlled study correlation analysis data analysis diet endothelium lesion female glucose blood level glycation hemoconcentration hemoglobin determination human hypertension inflammation insulin resistance insulinemia intermethod comparison lipid analysis male non insulin dependent diabetes mellitus pathophysiology sex difference smoking statistical significance thrombosis |
| description |
Endothelial dysfunction has been defined as an imbalance between relaxing and contracting factors and has been implicated in the pathophysiology of several cardiovascular disorders, hypertension and diabetes. Plasmatic levels of endothelin-1, nitric oxide, von Willebrand factor, fibrinogen, glycated haemoglobin, glycaemia, Insulinaemia, lipid profile and blood pressure in 30 hypertensive and type II diabetic patients and 25 healthy subjects matched in age, sex, body mass index and smoking and dietary habits, were evaluated in order to study the relationship among these variables in the diabetic prothrombotic state. Endothelin-1, nitric oxide, von Willebrand factor and fibrinogen levels were higher in patients than in controls (p < 0.05). There was a significant positive correlation between nitric oxide and insulinaemia (p < 0.05) and between nitric oxide and von Willebrand factor (p < 0.05) in the group of patients. These data suggest that the prothrombotic state in these patients could be determined by the increased levels of endothelin-1, the high but less bioavailable nitric oxide values, the endothelial damage and inflammatory state reflected by high von Willebrand factor and fibrinogen levels associated with dyslipidemia and the insulin-resistance state. |
| format |
JOUR |
| author |
Ouviña, S.M. Palmer, L. Sassetti, B. |
| author_facet |
Ouviña, S.M. Palmer, L. Sassetti, B. |
| author_sort |
Ouviña, S.M. |
| title |
Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients |
| title_short |
Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients |
| title_full |
Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients |
| title_fullStr |
Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients |
| title_full_unstemmed |
Endothelin-1, nitric oxide and von Willebrand factor in hypertensive type 2 diabetic patients |
| title_sort |
endothelin-1, nitric oxide and von willebrand factor in hypertensive type 2 diabetic patients |
| url |
http://hdl.handle.net/20.500.12110/paper_03252957_v38_n4_p471_Ouvina |
| work_keys_str_mv |
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