Is fibrinogen determination by prothrombine time derived method confidant?

Elevated plasma fibrinogen (Fbg) levels have been shown, to be a risk factor for thrombotic events and cardiovascular disease. Currently, Fbg concentration is measured by Clauss and the prothrombine-time derived method. Despite of the derived method is simple and rapid, several studies have suggeste...

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Detalles Bibliográficos
Autores principales: Lauricella, A.M., Duboscq, C.L., Castañon, M.M., Kordich, L.C.
Formato: JOUR
Materias:
Automated method
Clauss method
Fibrinogen
Prothrombine time test
fibrinogen
heparin
prothrombin
accuracy
article
cardiovascular disease
concentration response
correlation analysis
evaluation
heparinization
linear regression analysis
median test
protein blood level
protein determination
prothrombin time
risk factor
sampling
technique
thrombosis
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03252957_v36_n3_p329_Lauricella
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_03252957_v36_n3_p329_Lauricella
record_format dspace
spelling todo:paper_03252957_v36_n3_p329_Lauricella2023-10-03T15:23:34Z Is fibrinogen determination by prothrombine time derived method confidant? Lauricella, A.M. Duboscq, C.L. Castañon, M.M. Kordich, L.C. Automated method Clauss method Fibrinogen Prothrombine time test fibrinogen heparin prothrombin accuracy article cardiovascular disease concentration response correlation analysis evaluation heparinization linear regression analysis median test protein blood level protein determination prothrombin time risk factor sampling technique thrombosis Elevated plasma fibrinogen (Fbg) levels have been shown, to be a risk factor for thrombotic events and cardiovascular disease. Currently, Fbg concentration is measured by Clauss and the prothrombine-time derived method. Despite of the derived method is simple and rapid, several studies have suggested that this technique would provide higher Fbg values than the real ones. In order to evaluate the accuracy of this method, the results were compared to those obtained by Clauss method (Bland-Altman procedure and Median test). Moreover, it was studied the heparine effect (0.2 to 0.6 UI/ml) on the Fbg levels determinated by prothrombine-time method (linear regression and Pearson correlation). The comparison between Fbg values obtained by Clauss and prothrombine-time derived methods, shows that results from both techniques are equivalent in the normal range. However, at Fbg values higher than 400 mg/dl another method, like Clauss, would be used. The results obtained by prothrombine-time derived method were not modified with heparinized samples in the therapeutic range. Fil:Lauricella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Duboscq, C.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Castañon, M.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kordich, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03252957_v36_n3_p329_Lauricella
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Automated method
Clauss method
Fibrinogen
Prothrombine time test
fibrinogen
heparin
prothrombin
accuracy
article
cardiovascular disease
concentration response
correlation analysis
evaluation
heparinization
linear regression analysis
median test
protein blood level
protein determination
prothrombin time
risk factor
sampling
technique
thrombosis
spellingShingle Automated method
Clauss method
Fibrinogen
Prothrombine time test
fibrinogen
heparin
prothrombin
accuracy
article
cardiovascular disease
concentration response
correlation analysis
evaluation
heparinization
linear regression analysis
median test
protein blood level
protein determination
prothrombin time
risk factor
sampling
technique
thrombosis
Lauricella, A.M.
Duboscq, C.L.
Castañon, M.M.
Kordich, L.C.
Is fibrinogen determination by prothrombine time derived method confidant?
topic_facet Automated method
Clauss method
Fibrinogen
Prothrombine time test
fibrinogen
heparin
prothrombin
accuracy
article
cardiovascular disease
concentration response
correlation analysis
evaluation
heparinization
linear regression analysis
median test
protein blood level
protein determination
prothrombin time
risk factor
sampling
technique
thrombosis
description Elevated plasma fibrinogen (Fbg) levels have been shown, to be a risk factor for thrombotic events and cardiovascular disease. Currently, Fbg concentration is measured by Clauss and the prothrombine-time derived method. Despite of the derived method is simple and rapid, several studies have suggested that this technique would provide higher Fbg values than the real ones. In order to evaluate the accuracy of this method, the results were compared to those obtained by Clauss method (Bland-Altman procedure and Median test). Moreover, it was studied the heparine effect (0.2 to 0.6 UI/ml) on the Fbg levels determinated by prothrombine-time method (linear regression and Pearson correlation). The comparison between Fbg values obtained by Clauss and prothrombine-time derived methods, shows that results from both techniques are equivalent in the normal range. However, at Fbg values higher than 400 mg/dl another method, like Clauss, would be used. The results obtained by prothrombine-time derived method were not modified with heparinized samples in the therapeutic range.
format JOUR
author Lauricella, A.M.
Duboscq, C.L.
Castañon, M.M.
Kordich, L.C.
author_facet Lauricella, A.M.
Duboscq, C.L.
Castañon, M.M.
Kordich, L.C.
author_sort Lauricella, A.M.
title Is fibrinogen determination by prothrombine time derived method confidant?
title_short Is fibrinogen determination by prothrombine time derived method confidant?
title_full Is fibrinogen determination by prothrombine time derived method confidant?
title_fullStr Is fibrinogen determination by prothrombine time derived method confidant?
title_full_unstemmed Is fibrinogen determination by prothrombine time derived method confidant?
title_sort is fibrinogen determination by prothrombine time derived method confidant?
url http://hdl.handle.net/20.500.12110/paper_03252957_v36_n3_p329_Lauricella
work_keys_str_mv AT lauricellaam isfibrinogendeterminationbyprothrombinetimederivedmethodconfidant
AT duboscqcl isfibrinogendeterminationbyprothrombinetimederivedmethodconfidant
AT castanonmm isfibrinogendeterminationbyprothrombinetimederivedmethodconfidant
AT kordichlc isfibrinogendeterminationbyprothrombinetimederivedmethodconfidant
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