Cutaneous signs as parameter in teratogenicity by heavy metal intoxication
Teratogenic effects of heavy metals (Cd2+- and Pb 2+-acetates and Cu2+-sulphate) were studied on chick embryos, after the administration as a single dose. Test materials were injected into the yolk on day 12 of incubation. Tested concentrations were (nmole/g egg): Cd2+ Dose 1(D1): 0.16 and Dose 2 (D...
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todo:paper_03252787_v88_n1_p28_Pauza2023-10-03T15:23:27Z Cutaneous signs as parameter in teratogenicity by heavy metal intoxication Pauza, N.L. Pérez Cotti, M.J. Godar, M.L. Sopena, Y. Ferramola De Sancovich, A.M. Sancovich, H.A. Chick embryos Heavy metals Teratogenic effects Toxic effects Yolk sac membrane cadmium acetate copper sulfate lead acetate animal experiment animal model article body mass chick embryo controlled study embryo embryo mortality heavy metal poisoning liver hemorrhage nonhuman skin bleeding skin manifestation teratogenicity Teratogenic effects of heavy metals (Cd2+- and Pb 2+-acetates and Cu2+-sulphate) were studied on chick embryos, after the administration as a single dose. Test materials were injected into the yolk on day 12 of incubation. Tested concentrations were (nmole/g egg): Cd2+ Dose 1(D1): 0.16 and Dose 2 (D2): 0.32; Pb2+: D1: 8.0 and D2: 16.0 and Cu2+: D1: 1.7 and D2: 3.3. Evaluations were performed after in ovo incubation for 12 and 60 hours. Embryonic mortality did not increase at the two dose levels of Cu2+ and Pb2+, while Cd2+ caused 30 and 86% of mortality, showing dose and time responses. Eggs treated with D2 of Cd2+ for 60 hs, significantly decreased the average of body mass embryo, when compared to the control group. Cd2+ administration was resposible for the most severe teratogenic signs compared to Cu2+ and Pb2+ treatments. It can be concluded that heavy metals are embryotoxic and teratogenics. We suggest that cutaneous and liver hemorrhages are the best signs to evaluate teratogenicity induced by Cd2+, Cu2+ and Pb2+. Fil:Pauza, N.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ferramola De Sancovich, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sancovich, H.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03252787_v88_n1_p28_Pauza |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Chick embryos Heavy metals Teratogenic effects Toxic effects Yolk sac membrane cadmium acetate copper sulfate lead acetate animal experiment animal model article body mass chick embryo controlled study embryo embryo mortality heavy metal poisoning liver hemorrhage nonhuman skin bleeding skin manifestation teratogenicity |
| spellingShingle |
Chick embryos Heavy metals Teratogenic effects Toxic effects Yolk sac membrane cadmium acetate copper sulfate lead acetate animal experiment animal model article body mass chick embryo controlled study embryo embryo mortality heavy metal poisoning liver hemorrhage nonhuman skin bleeding skin manifestation teratogenicity Pauza, N.L. Pérez Cotti, M.J. Godar, M.L. Sopena, Y. Ferramola De Sancovich, A.M. Sancovich, H.A. Cutaneous signs as parameter in teratogenicity by heavy metal intoxication |
| topic_facet |
Chick embryos Heavy metals Teratogenic effects Toxic effects Yolk sac membrane cadmium acetate copper sulfate lead acetate animal experiment animal model article body mass chick embryo controlled study embryo embryo mortality heavy metal poisoning liver hemorrhage nonhuman skin bleeding skin manifestation teratogenicity |
| description |
Teratogenic effects of heavy metals (Cd2+- and Pb 2+-acetates and Cu2+-sulphate) were studied on chick embryos, after the administration as a single dose. Test materials were injected into the yolk on day 12 of incubation. Tested concentrations were (nmole/g egg): Cd2+ Dose 1(D1): 0.16 and Dose 2 (D2): 0.32; Pb2+: D1: 8.0 and D2: 16.0 and Cu2+: D1: 1.7 and D2: 3.3. Evaluations were performed after in ovo incubation for 12 and 60 hours. Embryonic mortality did not increase at the two dose levels of Cu2+ and Pb2+, while Cd2+ caused 30 and 86% of mortality, showing dose and time responses. Eggs treated with D2 of Cd2+ for 60 hs, significantly decreased the average of body mass embryo, when compared to the control group. Cd2+ administration was resposible for the most severe teratogenic signs compared to Cu2+ and Pb2+ treatments. It can be concluded that heavy metals are embryotoxic and teratogenics. We suggest that cutaneous and liver hemorrhages are the best signs to evaluate teratogenicity induced by Cd2+, Cu2+ and Pb2+. |
| format |
JOUR |
| author |
Pauza, N.L. Pérez Cotti, M.J. Godar, M.L. Sopena, Y. Ferramola De Sancovich, A.M. Sancovich, H.A. |
| author_facet |
Pauza, N.L. Pérez Cotti, M.J. Godar, M.L. Sopena, Y. Ferramola De Sancovich, A.M. Sancovich, H.A. |
| author_sort |
Pauza, N.L. |
| title |
Cutaneous signs as parameter in teratogenicity by heavy metal intoxication |
| title_short |
Cutaneous signs as parameter in teratogenicity by heavy metal intoxication |
| title_full |
Cutaneous signs as parameter in teratogenicity by heavy metal intoxication |
| title_fullStr |
Cutaneous signs as parameter in teratogenicity by heavy metal intoxication |
| title_full_unstemmed |
Cutaneous signs as parameter in teratogenicity by heavy metal intoxication |
| title_sort |
cutaneous signs as parameter in teratogenicity by heavy metal intoxication |
| url |
http://hdl.handle.net/20.500.12110/paper_03252787_v88_n1_p28_Pauza |
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