Influence of HLA-DR alleles on rheumatoid arthritis: Susceptibility and severity in Argentine patients
Objective. To determine the frequency of shared epitopes in our population of patients with rheumatoid arthritis (RA) and to investigate whether the presence of these alleles is associated with a more aggressive form of disease. Methods. Demographic and clinical data were obtained from 140 patients...
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todo:paper_0315162X_v28_n7_p1486_Citera2023-10-03T15:23:12Z Influence of HLA-DR alleles on rheumatoid arthritis: Susceptibility and severity in Argentine patients Citera, G. Padulo, L.A. Fernandez, G. Lazaro, M.A. Rosemffet, M.G. Maldonado Cocco, J.A. Disease severity HLA-DR alleles Rheumatoid arthritis Shared epitope epitope HLA DR antigen HLA DR11 antigen HLA DR3 antigen HLA DR4 antigen unclassified drug adult aged allelism Argentina article controlled study disease duration disease predisposition disease severity female hand radiography human major clinical study male polymerase chain reaction priority journal rheumatoid arthritis scoring system Adult Aged Alleles Argentina Arthritis, Rheumatoid Epitopes Female Genetic Predisposition to Disease Genotype HLA-DR Antigens HLA-DR3 Antigen Humans Male Middle Aged Severity of Illness Index Objective. To determine the frequency of shared epitopes in our population of patients with rheumatoid arthritis (RA) and to investigate whether the presence of these alleles is associated with a more aggressive form of disease. Methods. Demographic and clinical data were obtained from 140 patients with RA, 123 female, mean age 49.9 ± 11.7 years and mean disease duration 9.4 ± 6.3 years. Radiographs of both hands were taken and scored by Larsen's method. HLA-DR alleles were determined by PCR-SSP. The control group comprised 202 healthy ethnic-matched subjects. Results. DR4 was significantly more frequent in patients with RA than controls, and was observed in 70/140 patients (50%) versus 47/202 controls (23.27%) (odds ratio 3.25, CI 1.99-5.35, Pcorr 5 × 10-5). Within DR4 subtypes *0404 and *0401 were the most commonly found (37.7 and 29%, respectively). DR3 and DR11 exerted a protective effect with significantly higher frequency in controls than in patients with RA. When patients were divided into 2 groups according to disease severity (radiographic score) the frequency of alleles with QKRAA and QRRAA sequences was similar in both groups. Although with lower frequency, subtype *1001 alone was significantly more frequent in the severe-condition group [7 (13.5 %) vs 3 (3.4 %), p = 0.03]. Conclusion. These results are in accordance with findings observed in Caucasians and differ from other Latin American populations. However shared epitope alleles failed to correlate with more severe disease with the exception of subtype *1001 which, although infrequent, was significantly more frequent in patients with relevant radiological damage. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0315162X_v28_n7_p1486_Citera |
| institution |
Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Disease severity HLA-DR alleles Rheumatoid arthritis Shared epitope epitope HLA DR antigen HLA DR11 antigen HLA DR3 antigen HLA DR4 antigen unclassified drug adult aged allelism Argentina article controlled study disease duration disease predisposition disease severity female hand radiography human major clinical study male polymerase chain reaction priority journal rheumatoid arthritis scoring system Adult Aged Alleles Argentina Arthritis, Rheumatoid Epitopes Female Genetic Predisposition to Disease Genotype HLA-DR Antigens HLA-DR3 Antigen Humans Male Middle Aged Severity of Illness Index |
| spellingShingle |
Disease severity HLA-DR alleles Rheumatoid arthritis Shared epitope epitope HLA DR antigen HLA DR11 antigen HLA DR3 antigen HLA DR4 antigen unclassified drug adult aged allelism Argentina article controlled study disease duration disease predisposition disease severity female hand radiography human major clinical study male polymerase chain reaction priority journal rheumatoid arthritis scoring system Adult Aged Alleles Argentina Arthritis, Rheumatoid Epitopes Female Genetic Predisposition to Disease Genotype HLA-DR Antigens HLA-DR3 Antigen Humans Male Middle Aged Severity of Illness Index Citera, G. Padulo, L.A. Fernandez, G. Lazaro, M.A. Rosemffet, M.G. Maldonado Cocco, J.A. Influence of HLA-DR alleles on rheumatoid arthritis: Susceptibility and severity in Argentine patients |
| topic_facet |
Disease severity HLA-DR alleles Rheumatoid arthritis Shared epitope epitope HLA DR antigen HLA DR11 antigen HLA DR3 antigen HLA DR4 antigen unclassified drug adult aged allelism Argentina article controlled study disease duration disease predisposition disease severity female hand radiography human major clinical study male polymerase chain reaction priority journal rheumatoid arthritis scoring system Adult Aged Alleles Argentina Arthritis, Rheumatoid Epitopes Female Genetic Predisposition to Disease Genotype HLA-DR Antigens HLA-DR3 Antigen Humans Male Middle Aged Severity of Illness Index |
| description |
Objective. To determine the frequency of shared epitopes in our population of patients with rheumatoid arthritis (RA) and to investigate whether the presence of these alleles is associated with a more aggressive form of disease. Methods. Demographic and clinical data were obtained from 140 patients with RA, 123 female, mean age 49.9 ± 11.7 years and mean disease duration 9.4 ± 6.3 years. Radiographs of both hands were taken and scored by Larsen's method. HLA-DR alleles were determined by PCR-SSP. The control group comprised 202 healthy ethnic-matched subjects. Results. DR4 was significantly more frequent in patients with RA than controls, and was observed in 70/140 patients (50%) versus 47/202 controls (23.27%) (odds ratio 3.25, CI 1.99-5.35, Pcorr 5 × 10-5). Within DR4 subtypes *0404 and *0401 were the most commonly found (37.7 and 29%, respectively). DR3 and DR11 exerted a protective effect with significantly higher frequency in controls than in patients with RA. When patients were divided into 2 groups according to disease severity (radiographic score) the frequency of alleles with QKRAA and QRRAA sequences was similar in both groups. Although with lower frequency, subtype *1001 alone was significantly more frequent in the severe-condition group [7 (13.5 %) vs 3 (3.4 %), p = 0.03]. Conclusion. These results are in accordance with findings observed in Caucasians and differ from other Latin American populations. However shared epitope alleles failed to correlate with more severe disease with the exception of subtype *1001 which, although infrequent, was significantly more frequent in patients with relevant radiological damage. |
| format |
JOUR |
| author |
Citera, G. Padulo, L.A. Fernandez, G. Lazaro, M.A. Rosemffet, M.G. Maldonado Cocco, J.A. |
| author_facet |
Citera, G. Padulo, L.A. Fernandez, G. Lazaro, M.A. Rosemffet, M.G. Maldonado Cocco, J.A. |
| author_sort |
Citera, G. |
| title |
Influence of HLA-DR alleles on rheumatoid arthritis: Susceptibility and severity in Argentine patients |
| title_short |
Influence of HLA-DR alleles on rheumatoid arthritis: Susceptibility and severity in Argentine patients |
| title_full |
Influence of HLA-DR alleles on rheumatoid arthritis: Susceptibility and severity in Argentine patients |
| title_fullStr |
Influence of HLA-DR alleles on rheumatoid arthritis: Susceptibility and severity in Argentine patients |
| title_full_unstemmed |
Influence of HLA-DR alleles on rheumatoid arthritis: Susceptibility and severity in Argentine patients |
| title_sort |
influence of hla-dr alleles on rheumatoid arthritis: susceptibility and severity in argentine patients |
| url |
http://hdl.handle.net/20.500.12110/paper_0315162X_v28_n7_p1486_Citera |
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