P/Q-type calcium channel ablation in a mice glycinergic synapse mediated by multiple types of Ca 2+ channels alters transmitter release and short term plasticity

Ca v2.1 channels (P/Q-type) play a prominent role in controlling neurotransmitter release. Transgenic mice in which the α1A pore-forming subunit of Ca v2.1 channels is ablated (KO) provide a powerful tool to study Ca v2.1 function in synaptic transmission in vivo. Whole-cell patch clamp was used to...

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Detalles Bibliográficos
Autores principales: Giugovaz-Tropper, B., González-Inchauspe, C., Di Guilmi, M.N., Urbano, F.J., Forsythe, I.D., Uchitel, O.D.
Formato: JOUR
Materias:
CaV2.1 KO mice
Inhibitory glycinergic postsynaptic currents
P/Q-type calcium channels
Pair pulse facilitation
Short term synaptic plasticity
4 aminobutyric acid B receptor
baclofen
calcium channel L type
calcium channel N type
calcium channel P type
calcium channel Q type
glycine receptor
guanine nucleotide binding protein
animal cell
article
brain function
controlled study
electroencephalogram
facilitation
nerve cell plasticity
nerve stimulation
neurotransmitter release
nonhuman
priority journal
protein expression
protein function
short term depression
synapse
synaptic transmission
Animals
Brain Stem
Calcium Channels
Calcium Channels, P-Type
Calcium Channels, Q-Type
Excitatory Postsynaptic Potentials
Glycine
Inhibitory Postsynaptic Potentials
Mice
Mice, Knockout
Mice, Transgenic
Neuronal Plasticity
Neurons
Neurotransmitter Agents
Organ Culture Techniques
Patch-Clamp Techniques
Synapses
Synaptic Transmission
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03064522_v192_n_p219_GiugovazTropper
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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