Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation

1. The effect of chronic enflurane or isoflurane anesthesia on hepatic heme regulation and the drug-metabolizing system in mice treated or not with phenobarbital (PB) was investigated. 2. δ-Aminolevulinic acid synthetase was induced 50-170% in all cases. Urinary porphyrin precursor excretion was als...

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Autores principales:	Buzaleh, A.M., Vazquez, E.S., Nuñez, G., Batlle, A.M.D.C.
Formato:	JOUR
Materias:	Chronic anesthesia Drug-metabolizing enzyme system Enflurane Heme metabolism Isoflurane 5 aminolevulinate synthase beta glucuronidase cytochrome p450 enflurane glutathione transferase isoflurane phenobarbital sulfatase tryptophan 2,3 dioxygenase anesthesia animal experiment article drug metabolism enzyme activity male mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Anesthetics, Inhalation Animals Cytochrome P-450 Enzyme System Heme Hypnotics and Sedatives Liver Male Mice Phenobarbital Porphobilinogen Porphyrins
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03063623_v28_n4_p577_Buzaleh
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03063623_v28_n4_p577_Buzaleh
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spelling	todo:paper_03063623_v28_n4_p577_Buzaleh2023-10-03T15:22:16Z Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation Buzaleh, A.M. Vazquez, E.S. Nuñez, G. Batlle, A.M.D.C. Chronic anesthesia Drug-metabolizing enzyme system Enflurane Heme metabolism Isoflurane 5 aminolevulinate synthase beta glucuronidase cytochrome p450 enflurane glutathione transferase isoflurane phenobarbital sulfatase tryptophan 2,3 dioxygenase anesthesia animal experiment article drug metabolism enzyme activity male mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Anesthetics, Inhalation Animals Cytochrome P-450 Enzyme System Enflurane Heme Hypnotics and Sedatives Isoflurane Liver Male Mice Phenobarbital Porphobilinogen Porphyrins 1. The effect of chronic enflurane or isoflurane anesthesia on hepatic heme regulation and the drug-metabolizing system in mice treated or not with phenobarbital (PB) was investigated. 2. δ-Aminolevulinic acid synthetase was induced 50-170% in all cases. Urinary porphyrin precursor excretion was also enhanced, but these values were lower when animals also received PB. 3. Cytochrome (CYT) P-450 levels were enhanced in animals treated with enflurane whether or not they were given PB. 4. Gluthatione-S-transferase activity was induced by enflurane (138%) or isoflurane (174%), and even more in animals receiving PB also. Sulfatase activity was increased more than 60% with anesthetics. Isoflurane produced a 50% increase of β-glucuronidase activity and a 35% diminution of tryptophan pyrrolase. 5. The association between anesthetics and PB produced diverse effects on the metabolizing enzyme system. 6. Data suggest that both anesthetics, chemically related, could act through two different mechanisms, however, with the same final effect: heme pathway deregulation. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Batlle, A.M.D.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03063623_v28_n4_p577_Buzaleh
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Chronic anesthesia Drug-metabolizing enzyme system Enflurane Heme metabolism Isoflurane 5 aminolevulinate synthase beta glucuronidase cytochrome p450 enflurane glutathione transferase isoflurane phenobarbital sulfatase tryptophan 2,3 dioxygenase anesthesia animal experiment article drug metabolism enzyme activity male mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Anesthetics, Inhalation Animals Cytochrome P-450 Enzyme System Enflurane Heme Hypnotics and Sedatives Isoflurane Liver Male Mice Phenobarbital Porphobilinogen Porphyrins
spellingShingle	Chronic anesthesia Drug-metabolizing enzyme system Enflurane Heme metabolism Isoflurane 5 aminolevulinate synthase beta glucuronidase cytochrome p450 enflurane glutathione transferase isoflurane phenobarbital sulfatase tryptophan 2,3 dioxygenase anesthesia animal experiment article drug metabolism enzyme activity male mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Anesthetics, Inhalation Animals Cytochrome P-450 Enzyme System Enflurane Heme Hypnotics and Sedatives Isoflurane Liver Male Mice Phenobarbital Porphobilinogen Porphyrins Buzaleh, A.M. Vazquez, E.S. Nuñez, G. Batlle, A.M.D.C. Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation
topic_facet	Chronic anesthesia Drug-metabolizing enzyme system Enflurane Heme metabolism Isoflurane 5 aminolevulinate synthase beta glucuronidase cytochrome p450 enflurane glutathione transferase isoflurane phenobarbital sulfatase tryptophan 2,3 dioxygenase anesthesia animal experiment article drug metabolism enzyme activity male mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Anesthetics, Inhalation Animals Cytochrome P-450 Enzyme System Enflurane Heme Hypnotics and Sedatives Isoflurane Liver Male Mice Phenobarbital Porphobilinogen Porphyrins
description	1. The effect of chronic enflurane or isoflurane anesthesia on hepatic heme regulation and the drug-metabolizing system in mice treated or not with phenobarbital (PB) was investigated. 2. δ-Aminolevulinic acid synthetase was induced 50-170% in all cases. Urinary porphyrin precursor excretion was also enhanced, but these values were lower when animals also received PB. 3. Cytochrome (CYT) P-450 levels were enhanced in animals treated with enflurane whether or not they were given PB. 4. Gluthatione-S-transferase activity was induced by enflurane (138%) or isoflurane (174%), and even more in animals receiving PB also. Sulfatase activity was increased more than 60% with anesthetics. Isoflurane produced a 50% increase of β-glucuronidase activity and a 35% diminution of tryptophan pyrrolase. 5. The association between anesthetics and PB produced diverse effects on the metabolizing enzyme system. 6. Data suggest that both anesthetics, chemically related, could act through two different mechanisms, however, with the same final effect: heme pathway deregulation.
format	JOUR
author	Buzaleh, A.M. Vazquez, E.S. Nuñez, G. Batlle, A.M.D.C.
author_facet	Buzaleh, A.M. Vazquez, E.S. Nuñez, G. Batlle, A.M.D.C.
author_sort	Buzaleh, A.M.
title	Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation
title_short	Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation
title_full	Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation
title_fullStr	Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation
title_full_unstemmed	Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation
title_sort	effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation
url	http://hdl.handle.net/20.500.12110/paper_03063623_v28_n4_p577_Buzaleh
work_keys_str_mv	AT buzaleham effectofchronicanesthesiaonthedrugmetabolizingenzymesystemandhemepathwayregulation AT vazquezes effectofchronicanesthesiaonthedrugmetabolizingenzymesystemandhemepathwayregulation AT nunezg effectofchronicanesthesiaonthedrugmetabolizingenzymesystemandhemepathwayregulation AT batlleamdc effectofchronicanesthesiaonthedrugmetabolizingenzymesystemandhemepathwayregulation
_version_	1807323533624213504

Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation

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