Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice
The influence of strain and sex on the effect of enflurane and isoflurane administration on heme metabolism was investigated to identify the animal model which could best reproduce the biochemical signs of acute intermittent porphyria. Enflurane produced 35% and 80% increases in ALA-S activity only...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_03063623_v27_n6_p1009_Buzaleh |
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todo:paper_03063623_v27_n6_p1009_Buzaleh2023-10-03T15:22:15Z Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice Buzaleh, A.M. Del Carmen Batlle, A.M. acute intermittent porphyria enflurane heme metabolism isoflurane sex strain 5 aminolevulinate synthase enflurane heme isoflurane porphobilinogen deaminase porphobilinogen synthase acute intermittent porphyria animal experiment animal model article controlled study enzyme activity enzyme blood level female heme synthesis intraperitoneal drug administration male metabolism mouse nonhuman priority journal sex difference strain difference The influence of strain and sex on the effect of enflurane and isoflurane administration on heme metabolism was investigated to identify the animal model which could best reproduce the biochemical signs of acute intermittent porphyria. Enflurane produced 35% and 80% increases in ALA-S activity only in CF1 male and female mice, respectively, whereas isoflurane induced 40% enzyme activity in CF1 male. CF1 males showed around 35% decrease in blood PBGase and PBG-deaminase after administration of enflurane, whereas isoflurane provoked a striking inhibition (70%) in males of the C57 strain. Enflurane produced alterations in heme synthesis, which would fit a model of acute porphyria in CF1 male mice. On the other hand, isoflurane would mimic biochemical alterations of this porphyria in C57 males. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Carmen Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03063623_v27_n6_p1009_Buzaleh |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
acute intermittent porphyria enflurane heme metabolism isoflurane sex strain 5 aminolevulinate synthase enflurane heme isoflurane porphobilinogen deaminase porphobilinogen synthase acute intermittent porphyria animal experiment animal model article controlled study enzyme activity enzyme blood level female heme synthesis intraperitoneal drug administration male metabolism mouse nonhuman priority journal sex difference strain difference |
| spellingShingle |
acute intermittent porphyria enflurane heme metabolism isoflurane sex strain 5 aminolevulinate synthase enflurane heme isoflurane porphobilinogen deaminase porphobilinogen synthase acute intermittent porphyria animal experiment animal model article controlled study enzyme activity enzyme blood level female heme synthesis intraperitoneal drug administration male metabolism mouse nonhuman priority journal sex difference strain difference Buzaleh, A.M. Del Carmen Batlle, A.M. Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice |
| topic_facet |
acute intermittent porphyria enflurane heme metabolism isoflurane sex strain 5 aminolevulinate synthase enflurane heme isoflurane porphobilinogen deaminase porphobilinogen synthase acute intermittent porphyria animal experiment animal model article controlled study enzyme activity enzyme blood level female heme synthesis intraperitoneal drug administration male metabolism mouse nonhuman priority journal sex difference strain difference |
| description |
The influence of strain and sex on the effect of enflurane and isoflurane administration on heme metabolism was investigated to identify the animal model which could best reproduce the biochemical signs of acute intermittent porphyria. Enflurane produced 35% and 80% increases in ALA-S activity only in CF1 male and female mice, respectively, whereas isoflurane induced 40% enzyme activity in CF1 male. CF1 males showed around 35% decrease in blood PBGase and PBG-deaminase after administration of enflurane, whereas isoflurane provoked a striking inhibition (70%) in males of the C57 strain. Enflurane produced alterations in heme synthesis, which would fit a model of acute porphyria in CF1 male mice. On the other hand, isoflurane would mimic biochemical alterations of this porphyria in C57 males. |
| format |
JOUR |
| author |
Buzaleh, A.M. Del Carmen Batlle, A.M. |
| author_facet |
Buzaleh, A.M. Del Carmen Batlle, A.M. |
| author_sort |
Buzaleh, A.M. |
| title |
Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice |
| title_short |
Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice |
| title_full |
Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice |
| title_fullStr |
Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice |
| title_full_unstemmed |
Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice |
| title_sort |
strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice |
| url |
http://hdl.handle.net/20.500.12110/paper_03063623_v27_n6_p1009_Buzaleh |
| work_keys_str_mv |
AT buzaleham strainandsexdifferencesintheeffectofenfluraneandisofluraneonhememetabolisminmice AT delcarmenbatlleam strainandsexdifferencesintheeffectofenfluraneandisofluraneonhememetabolisminmice |
| _version_ |
1807318608288677888 |