Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption
1. 1. The effect of enflurane or isoflurane anesthesia (1 ml/kg, i.p.) in animals chronically treated with ethanol (30%, v/v, in drinking water during a week) on heme metabolism and its regulation was investigated. 2. 2. In those animals previously intoxicated with ethanol that received isoflurane,...
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todo:paper_03063623_v26_n6_p1425_Buzaleh2023-10-03T15:22:14Z Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption Buzaleh, A.M. Vazquez, E.S. Del C. Batlle, A.M. acute intermittent porphyria aminolevulinic acid synthetase Enflurane ethanol heme metabolism heme oxygenase isoflurane porfobilinogen deaminase porfobilinogenase rhodanese 5 aminolevulinate synthase deaminase enflurane isoflurane organofluorine derivative porphobilinogenase unclassified drug acute intermittent porphyria alcohol consumption anesthesia animal model article blood controlled study drug efficacy intraperitoneal drug administration liver male metabolic regulation mouse nonhuman priority journal Animal Enflurane Ethanol Ethers Heme Liver Male Mice Mice, Inbred Strains Support, Non-U.S. Gov't Time Factors 1. 1. The effect of enflurane or isoflurane anesthesia (1 ml/kg, i.p.) in animals chronically treated with ethanol (30%, v/v, in drinking water during a week) on heme metabolism and its regulation was investigated. 2. 2. In those animals previously intoxicated with ethanol that received isoflurane, ALA-S activity was increased (control values: 0.071 ± 0.022 nmol/mg, n = 10; treated animals: 0.110 ± 0.034 nmol/mg, n = 8) and blood PBGase and deaminase were strikingly diminished (control values, n = 10: PBGase: 0.101 ± 0.015 nmol/mg, deaminase: 0.242 ± 0.075 nmol/mg; treated animals, n = 6: PBGase: 0.063 ± 0.013 nmol/mg; deaminase: 0.145 ± 0.045 nmol/mg). 3. 3. The time-response study showed that liver ALA-S is enhanced at shorter times of anesthesia with isoflurane and that blood PBGase and deaminase appeared inhibited later in animals previously treated with ethanol. 4. 4. Results reproduce some biochemical alterations known to occur in acute intermittent porphyria. © 1995. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03063623_v26_n6_p1425_Buzaleh |
| institution |
Universidad de Buenos Aires |
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I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
acute intermittent porphyria aminolevulinic acid synthetase Enflurane ethanol heme metabolism heme oxygenase isoflurane porfobilinogen deaminase porfobilinogenase rhodanese 5 aminolevulinate synthase deaminase enflurane isoflurane organofluorine derivative porphobilinogenase unclassified drug acute intermittent porphyria alcohol consumption anesthesia animal model article blood controlled study drug efficacy intraperitoneal drug administration liver male metabolic regulation mouse nonhuman priority journal Animal Enflurane Ethanol Ethers Heme Liver Male Mice Mice, Inbred Strains Support, Non-U.S. Gov't Time Factors |
| spellingShingle |
acute intermittent porphyria aminolevulinic acid synthetase Enflurane ethanol heme metabolism heme oxygenase isoflurane porfobilinogen deaminase porfobilinogenase rhodanese 5 aminolevulinate synthase deaminase enflurane isoflurane organofluorine derivative porphobilinogenase unclassified drug acute intermittent porphyria alcohol consumption anesthesia animal model article blood controlled study drug efficacy intraperitoneal drug administration liver male metabolic regulation mouse nonhuman priority journal Animal Enflurane Ethanol Ethers Heme Liver Male Mice Mice, Inbred Strains Support, Non-U.S. Gov't Time Factors Buzaleh, A.M. Vazquez, E.S. Del C. Batlle, A.M. Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption |
| topic_facet |
acute intermittent porphyria aminolevulinic acid synthetase Enflurane ethanol heme metabolism heme oxygenase isoflurane porfobilinogen deaminase porfobilinogenase rhodanese 5 aminolevulinate synthase deaminase enflurane isoflurane organofluorine derivative porphobilinogenase unclassified drug acute intermittent porphyria alcohol consumption anesthesia animal model article blood controlled study drug efficacy intraperitoneal drug administration liver male metabolic regulation mouse nonhuman priority journal Animal Enflurane Ethanol Ethers Heme Liver Male Mice Mice, Inbred Strains Support, Non-U.S. Gov't Time Factors |
| description |
1. 1. The effect of enflurane or isoflurane anesthesia (1 ml/kg, i.p.) in animals chronically treated with ethanol (30%, v/v, in drinking water during a week) on heme metabolism and its regulation was investigated. 2. 2. In those animals previously intoxicated with ethanol that received isoflurane, ALA-S activity was increased (control values: 0.071 ± 0.022 nmol/mg, n = 10; treated animals: 0.110 ± 0.034 nmol/mg, n = 8) and blood PBGase and deaminase were strikingly diminished (control values, n = 10: PBGase: 0.101 ± 0.015 nmol/mg, deaminase: 0.242 ± 0.075 nmol/mg; treated animals, n = 6: PBGase: 0.063 ± 0.013 nmol/mg; deaminase: 0.145 ± 0.045 nmol/mg). 3. 3. The time-response study showed that liver ALA-S is enhanced at shorter times of anesthesia with isoflurane and that blood PBGase and deaminase appeared inhibited later in animals previously treated with ethanol. 4. 4. Results reproduce some biochemical alterations known to occur in acute intermittent porphyria. © 1995. |
| format |
JOUR |
| author |
Buzaleh, A.M. Vazquez, E.S. Del C. Batlle, A.M. |
| author_facet |
Buzaleh, A.M. Vazquez, E.S. Del C. Batlle, A.M. |
| author_sort |
Buzaleh, A.M. |
| title |
Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption |
| title_short |
Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption |
| title_full |
Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption |
| title_fullStr |
Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption |
| title_full_unstemmed |
Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption |
| title_sort |
alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption |
| url |
http://hdl.handle.net/20.500.12110/paper_03063623_v26_n6_p1425_Buzaleh |
| work_keys_str_mv |
AT buzaleham alterationsinfluorinatedetheranestheticseffectsonhememetabolismfollowingchronicethanolconsumption AT vazquezes alterationsinfluorinatedetheranestheticseffectsonhememetabolismfollowingchronicethanolconsumption AT delcbatlleam alterationsinfluorinatedetheranestheticseffectsonhememetabolismfollowingchronicethanolconsumption |
| _version_ |
1807318258274009088 |