Porphyrinogenic properties of the anesthetic enflurane
1. 1. The effect of enflurane, a volatile anesthetic, on heme metabolism was studied. Different doses (0.5-6.0 ml/kg) of this anesthetic were administered i.p. to mice and animals sacrificed at different times after administration (5-240 min). 2. 2. The dose of 2 ml/kg was chosen as the optimum anes...
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todo:paper_03063623_v23_n4_p665_Buzaleh2023-10-03T15:22:13Z Porphyrinogenic properties of the anesthetic enflurane Buzaleh, A.M. de Salamanca, R.E. del C. Batlle, A.M. 5 aminolevulinate synthase anesthetic agent deaminase enflurane heme animal experiment animal tissue article controlled study dose time effect relation enzyme activity heme synthesis intraperitoneal drug administration kidney liver metabolism mouse nonhuman porphyria priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Blood Glucose Enflurane Glucose Heme Kidney Liver Mice Porphyrins Support, Non-U.S. Gov't 1. 1. The effect of enflurane, a volatile anesthetic, on heme metabolism was studied. Different doses (0.5-6.0 ml/kg) of this anesthetic were administered i.p. to mice and animals sacrificed at different times after administration (5-240 min). 2. 2. The dose of 2 ml/kg was chosen as the optimum anesthetic dose producing more alterations in the heme pathway. 3. 3. ALA-S was significantly induced at earlier times of anesthesia. 4. 4. Blood PBGase and deaminase was greatly reduced. 5. 5. This diminution coupled with ALA-S induction are in accordance with the known biochemical changes occurring in acute intermittent porphyria and include enflurane in the list of porphyrinogenic drugs, the use of which is not recommended for the management of anesthesia in porphyric patients. © 1992. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03063623_v23_n4_p665_Buzaleh |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
5 aminolevulinate synthase anesthetic agent deaminase enflurane heme animal experiment animal tissue article controlled study dose time effect relation enzyme activity heme synthesis intraperitoneal drug administration kidney liver metabolism mouse nonhuman porphyria priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Blood Glucose Enflurane Glucose Heme Kidney Liver Mice Porphyrins Support, Non-U.S. Gov't |
| spellingShingle |
5 aminolevulinate synthase anesthetic agent deaminase enflurane heme animal experiment animal tissue article controlled study dose time effect relation enzyme activity heme synthesis intraperitoneal drug administration kidney liver metabolism mouse nonhuman porphyria priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Blood Glucose Enflurane Glucose Heme Kidney Liver Mice Porphyrins Support, Non-U.S. Gov't Buzaleh, A.M. de Salamanca, R.E. del C. Batlle, A.M. Porphyrinogenic properties of the anesthetic enflurane |
| topic_facet |
5 aminolevulinate synthase anesthetic agent deaminase enflurane heme animal experiment animal tissue article controlled study dose time effect relation enzyme activity heme synthesis intraperitoneal drug administration kidney liver metabolism mouse nonhuman porphyria priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Blood Glucose Enflurane Glucose Heme Kidney Liver Mice Porphyrins Support, Non-U.S. Gov't |
| description |
1. 1. The effect of enflurane, a volatile anesthetic, on heme metabolism was studied. Different doses (0.5-6.0 ml/kg) of this anesthetic were administered i.p. to mice and animals sacrificed at different times after administration (5-240 min). 2. 2. The dose of 2 ml/kg was chosen as the optimum anesthetic dose producing more alterations in the heme pathway. 3. 3. ALA-S was significantly induced at earlier times of anesthesia. 4. 4. Blood PBGase and deaminase was greatly reduced. 5. 5. This diminution coupled with ALA-S induction are in accordance with the known biochemical changes occurring in acute intermittent porphyria and include enflurane in the list of porphyrinogenic drugs, the use of which is not recommended for the management of anesthesia in porphyric patients. © 1992. |
| format |
JOUR |
| author |
Buzaleh, A.M. de Salamanca, R.E. del C. Batlle, A.M. |
| author_facet |
Buzaleh, A.M. de Salamanca, R.E. del C. Batlle, A.M. |
| author_sort |
Buzaleh, A.M. |
| title |
Porphyrinogenic properties of the anesthetic enflurane |
| title_short |
Porphyrinogenic properties of the anesthetic enflurane |
| title_full |
Porphyrinogenic properties of the anesthetic enflurane |
| title_fullStr |
Porphyrinogenic properties of the anesthetic enflurane |
| title_full_unstemmed |
Porphyrinogenic properties of the anesthetic enflurane |
| title_sort |
porphyrinogenic properties of the anesthetic enflurane |
| url |
http://hdl.handle.net/20.500.12110/paper_03063623_v23_n4_p665_Buzaleh |
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AT buzaleham porphyrinogenicpropertiesoftheanestheticenflurane AT desalamancare porphyrinogenicpropertiesoftheanestheticenflurane AT delcbatlleam porphyrinogenicpropertiesoftheanestheticenflurane |
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1807317203432767488 |