Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses

1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid d...

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Detalles Bibliográficos
Autores principales: Buzaleh, A.M., Vazquez, E.S., Del Carmen Batlle, A.M.
Formato: JOUR
Materias:
cytochrome c oxidase
porphobilinogen synthase
s adenosylmethionine
thiocyanate
thiosulfate
thiosulfate sulfurtransferase
animal experiment
article
controlled study
cyanide poisoning
detoxification
intraperitoneal drug administration
mouse
nonhuman
priority journal
Animal
Cyanides
Cytochrome-c Oxidase
Lethal Dose 50
Mice
Porphobilinogen Synthase
Proteins
S-Adenosylmethionine
Sulfur Radioisotopes
Support, Non-U.S. Gov't
Thiocyanates
Thiosulfate Sulfurtransferase
Thiosulfates
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03063623_v21_n1_p27_Buzaleh
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid dehydratase (ALA-D) activity. 3. 3. The toxic metabolizing degree was investigated by measuring plasma and urine thiocyanate levels. 4. 4. The state of the sulfane sulfur pool was investigated by determining cyanide labile-sulfur levels. 5. 5. These results support the belief that rhodanese plays a fundamental role in the detoxification process only when high levels of cyanide are administered. © 1990.

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