Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses
1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid d...
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todo:paper_03063623_v21_n1_p27_Buzaleh2023-10-03T15:22:10Z Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses Buzaleh, A.M. Vazquez, E.S. Del Carmen Batlle, A.M. cytochrome c oxidase porphobilinogen synthase s adenosylmethionine thiocyanate thiosulfate thiosulfate sulfurtransferase animal experiment article controlled study cyanide poisoning detoxification intraperitoneal drug administration mouse nonhuman priority journal Animal Cyanides Cytochrome-c Oxidase Lethal Dose 50 Mice Porphobilinogen Synthase Proteins S-Adenosylmethionine Sulfur Radioisotopes Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Thiosulfates 1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid dehydratase (ALA-D) activity. 3. 3. The toxic metabolizing degree was investigated by measuring plasma and urine thiocyanate levels. 4. 4. The state of the sulfane sulfur pool was investigated by determining cyanide labile-sulfur levels. 5. 5. These results support the belief that rhodanese plays a fundamental role in the detoxification process only when high levels of cyanide are administered. © 1990. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Carmen Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03063623_v21_n1_p27_Buzaleh |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
cytochrome c oxidase porphobilinogen synthase s adenosylmethionine thiocyanate thiosulfate thiosulfate sulfurtransferase animal experiment article controlled study cyanide poisoning detoxification intraperitoneal drug administration mouse nonhuman priority journal Animal Cyanides Cytochrome-c Oxidase Lethal Dose 50 Mice Porphobilinogen Synthase Proteins S-Adenosylmethionine Sulfur Radioisotopes Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Thiosulfates |
| spellingShingle |
cytochrome c oxidase porphobilinogen synthase s adenosylmethionine thiocyanate thiosulfate thiosulfate sulfurtransferase animal experiment article controlled study cyanide poisoning detoxification intraperitoneal drug administration mouse nonhuman priority journal Animal Cyanides Cytochrome-c Oxidase Lethal Dose 50 Mice Porphobilinogen Synthase Proteins S-Adenosylmethionine Sulfur Radioisotopes Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Thiosulfates Buzaleh, A.M. Vazquez, E.S. Del Carmen Batlle, A.M. Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses |
| topic_facet |
cytochrome c oxidase porphobilinogen synthase s adenosylmethionine thiocyanate thiosulfate thiosulfate sulfurtransferase animal experiment article controlled study cyanide poisoning detoxification intraperitoneal drug administration mouse nonhuman priority journal Animal Cyanides Cytochrome-c Oxidase Lethal Dose 50 Mice Porphobilinogen Synthase Proteins S-Adenosylmethionine Sulfur Radioisotopes Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Thiosulfates |
| description |
1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid dehydratase (ALA-D) activity. 3. 3. The toxic metabolizing degree was investigated by measuring plasma and urine thiocyanate levels. 4. 4. The state of the sulfane sulfur pool was investigated by determining cyanide labile-sulfur levels. 5. 5. These results support the belief that rhodanese plays a fundamental role in the detoxification process only when high levels of cyanide are administered. © 1990. |
| format |
JOUR |
| author |
Buzaleh, A.M. Vazquez, E.S. Del Carmen Batlle, A.M. |
| author_facet |
Buzaleh, A.M. Vazquez, E.S. Del Carmen Batlle, A.M. |
| author_sort |
Buzaleh, A.M. |
| title |
Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses |
| title_short |
Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses |
| title_full |
Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses |
| title_fullStr |
Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses |
| title_full_unstemmed |
Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses |
| title_sort |
cyanide intoxication-iii. on the analogous and different effects provoked by non-lethal and lethal challenged doses |
| url |
http://hdl.handle.net/20.500.12110/paper_03063623_v21_n1_p27_Buzaleh |
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| _version_ |
1807323177118859264 |