Cyanide intoxication-I. An oral chronic animal model
The effects of oral chronic cyanide administration to mice were studied. Cyanide intoxication was confirmed by the increased levels of this poison and the concomitant inhibition of cytochrome oxidase activity in liver, brain, heart and blood. The detoxifying enzyme rhodanese was measured. The state...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_03063623_v20_n3_p323_Buzaleh |
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todo:paper_03063623_v20_n3_p323_Buzaleh2023-10-03T15:22:09Z Cyanide intoxication-I. An oral chronic animal model Buzaleh, A.M. Vazquez, E.S. Del Battle, C.A.M. cyanide cytochrome c oxidase thiocyanate thiosulfate sulfurtransferase animal cell animal experiment animal model blood brain detoxification heart intoxication liver mouse nonhuman priority journal Administration, Oral Animal Cyanides Cytochrome-c Oxidase Mice Proteins Sulfur Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Time Factors The effects of oral chronic cyanide administration to mice were studied. Cyanide intoxication was confirmed by the increased levels of this poison and the concomitant inhibition of cytochrome oxidase activity in liver, brain, heart and blood. The detoxifying enzyme rhodanese was measured. The state of the sulfane sulfur pool was investigated by determination of the cyanide labile-sulfur levels. A clear correlation between rhodanese activity and sulfur content was obtained as a consequence of cyanide action. These results support the belief that rhodanese plays a fundamental role in the detoxification process of cyanide, in preventing cyanide reaching the target tissues. © 1989. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03063623_v20_n3_p323_Buzaleh |
| institution |
Universidad de Buenos Aires |
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I-28 |
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R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
cyanide cytochrome c oxidase thiocyanate thiosulfate sulfurtransferase animal cell animal experiment animal model blood brain detoxification heart intoxication liver mouse nonhuman priority journal Administration, Oral Animal Cyanides Cytochrome-c Oxidase Mice Proteins Sulfur Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Time Factors |
| spellingShingle |
cyanide cytochrome c oxidase thiocyanate thiosulfate sulfurtransferase animal cell animal experiment animal model blood brain detoxification heart intoxication liver mouse nonhuman priority journal Administration, Oral Animal Cyanides Cytochrome-c Oxidase Mice Proteins Sulfur Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Time Factors Buzaleh, A.M. Vazquez, E.S. Del Battle, C.A.M. Cyanide intoxication-I. An oral chronic animal model |
| topic_facet |
cyanide cytochrome c oxidase thiocyanate thiosulfate sulfurtransferase animal cell animal experiment animal model blood brain detoxification heart intoxication liver mouse nonhuman priority journal Administration, Oral Animal Cyanides Cytochrome-c Oxidase Mice Proteins Sulfur Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Time Factors |
| description |
The effects of oral chronic cyanide administration to mice were studied. Cyanide intoxication was confirmed by the increased levels of this poison and the concomitant inhibition of cytochrome oxidase activity in liver, brain, heart and blood. The detoxifying enzyme rhodanese was measured. The state of the sulfane sulfur pool was investigated by determination of the cyanide labile-sulfur levels. A clear correlation between rhodanese activity and sulfur content was obtained as a consequence of cyanide action. These results support the belief that rhodanese plays a fundamental role in the detoxification process of cyanide, in preventing cyanide reaching the target tissues. © 1989. |
| format |
JOUR |
| author |
Buzaleh, A.M. Vazquez, E.S. Del Battle, C.A.M. |
| author_facet |
Buzaleh, A.M. Vazquez, E.S. Del Battle, C.A.M. |
| author_sort |
Buzaleh, A.M. |
| title |
Cyanide intoxication-I. An oral chronic animal model |
| title_short |
Cyanide intoxication-I. An oral chronic animal model |
| title_full |
Cyanide intoxication-I. An oral chronic animal model |
| title_fullStr |
Cyanide intoxication-I. An oral chronic animal model |
| title_full_unstemmed |
Cyanide intoxication-I. An oral chronic animal model |
| title_sort |
cyanide intoxication-i. an oral chronic animal model |
| url |
http://hdl.handle.net/20.500.12110/paper_03063623_v20_n3_p323_Buzaleh |
| work_keys_str_mv |
AT buzaleham cyanideintoxicationianoralchronicanimalmodel AT vazquezes cyanideintoxicationianoralchronicanimalmodel AT delbattlecam cyanideintoxicationianoralchronicanimalmodel |
| _version_ |
1807314537040314368 |