Antidepressant effect of chronic ethanol in adult rats

Increased dopamine (DA) and noradrenaline (NA) metabolites in whole brain as well as increased DA release in slices of caudate nucleus from ethanol dependent rats have been previously found. It is known that both DA and NA are present in caudate (CAU) and accumbens (ACC) nuclei. In view of this, pos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernandez-Pardal, J., Pezzot, M.C., Gimeno, A.L.
Formato:	JOUR
Materias:	alcohol dopamine haloperidol metirosine noradrenalin prazosin animal experiment caudate nucleus central nervous system drug blood level drug efficacy drug interaction etiology intraperitoneal drug administration nonhuman nucleus accumbens oral drug administration priority journal rat
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03056651_v13_n9_p822_FernandezPardal
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03056651_v13_n9_p822_FernandezPardal
record_format	dspace
spelling	todo:paper_03056651_v13_n9_p822_FernandezPardal2023-10-03T15:21:52Z Antidepressant effect of chronic ethanol in adult rats Fernandez-Pardal, J. Pezzot, M.C. Gimeno, A.L. alcohol dopamine haloperidol metirosine noradrenalin prazosin animal experiment caudate nucleus central nervous system drug blood level drug efficacy drug interaction etiology intraperitoneal drug administration nonhuman nucleus accumbens oral drug administration priority journal rat Increased dopamine (DA) and noradrenaline (NA) metabolites in whole brain as well as increased DA release in slices of caudate nucleus from ethanol dependent rats have been previously found. It is known that both DA and NA are present in caudate (CAU) and accumbens (ACC) nuclei. In view of this, possible relationships were explored between chronic ethanol administration, DA and NA metabolism in CAU and ACC nuclei and despair behaviour (depression). A liquid diet with or without ethanol was given to rats for 20 consecutive days. The turnovers of DA and NA were determined by an enzymatic-isotopic micromethod after alpha-methyl-p-tyrosine. Despair behaviour was measured as the immobility of rats in an animal model for depression, swimming test (ST). Chronic ethanol enhanced DA and NA turnovers in ACC and CAU nuclei in contrast to findings in the acute ethanol groups. Chronic ethanol decreased the duration of immobility in the ST apparently through the activation of alpha1-adrenoreceptors. This effect is possibly related to an antidepressant influence of chronic ethanol which requires further investigation. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03056651_v13_n9_p822_FernandezPardal
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	alcohol dopamine haloperidol metirosine noradrenalin prazosin animal experiment caudate nucleus central nervous system drug blood level drug efficacy drug interaction etiology intraperitoneal drug administration nonhuman nucleus accumbens oral drug administration priority journal rat
spellingShingle	alcohol dopamine haloperidol metirosine noradrenalin prazosin animal experiment caudate nucleus central nervous system drug blood level drug efficacy drug interaction etiology intraperitoneal drug administration nonhuman nucleus accumbens oral drug administration priority journal rat Fernandez-Pardal, J. Pezzot, M.C. Gimeno, A.L. Antidepressant effect of chronic ethanol in adult rats
topic_facet	alcohol dopamine haloperidol metirosine noradrenalin prazosin animal experiment caudate nucleus central nervous system drug blood level drug efficacy drug interaction etiology intraperitoneal drug administration nonhuman nucleus accumbens oral drug administration priority journal rat
description	Increased dopamine (DA) and noradrenaline (NA) metabolites in whole brain as well as increased DA release in slices of caudate nucleus from ethanol dependent rats have been previously found. It is known that both DA and NA are present in caudate (CAU) and accumbens (ACC) nuclei. In view of this, possible relationships were explored between chronic ethanol administration, DA and NA metabolism in CAU and ACC nuclei and despair behaviour (depression). A liquid diet with or without ethanol was given to rats for 20 consecutive days. The turnovers of DA and NA were determined by an enzymatic-isotopic micromethod after alpha-methyl-p-tyrosine. Despair behaviour was measured as the immobility of rats in an animal model for depression, swimming test (ST). Chronic ethanol enhanced DA and NA turnovers in ACC and CAU nuclei in contrast to findings in the acute ethanol groups. Chronic ethanol decreased the duration of immobility in the ST apparently through the activation of alpha1-adrenoreceptors. This effect is possibly related to an antidepressant influence of chronic ethanol which requires further investigation.
format	JOUR
author	Fernandez-Pardal, J. Pezzot, M.C. Gimeno, A.L.
author_facet	Fernandez-Pardal, J. Pezzot, M.C. Gimeno, A.L.
author_sort	Fernandez-Pardal, J.
title	Antidepressant effect of chronic ethanol in adult rats
title_short	Antidepressant effect of chronic ethanol in adult rats
title_full	Antidepressant effect of chronic ethanol in adult rats
title_fullStr	Antidepressant effect of chronic ethanol in adult rats
title_full_unstemmed	Antidepressant effect of chronic ethanol in adult rats
title_sort	antidepressant effect of chronic ethanol in adult rats
url	http://hdl.handle.net/20.500.12110/paper_03056651_v13_n9_p822_FernandezPardal
work_keys_str_mv	AT fernandezpardalj antidepressanteffectofchronicethanolinadultrats AT pezzotmc antidepressanteffectofchronicethanolinadultrats AT gimenoal antidepressanteffectofchronicethanolinadultrats
_version_	1807322050957672448

Antidepressant effect of chronic ethanol in adult rats

Ejemplares similares