Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine

In male Wistar rats intraperitoneal injection (21 days) of mianserin, a tetracyclic antidepressant (10 mg/kg), produced significant dimunition (p < 0.01) of brain noradrenaline content without any changes in dopamine or serotonin content. Amoxapine, a tricyclic antidepressant with a potent inhibi...

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Autores principales: Cicardo, V.H., Carneiro de Rondina, D., Mastronardi, I.O.
Formato: JOUR
Materias:
rat
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03056651_v11_n9_p838_Cicardo
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spelling todo:paper_03056651_v11_n9_p838_Cicardo2023-10-03T15:21:51Z Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine Cicardo, V.H. Carneiro de Rondina, D. Mastronardi, I.O. amoxapine brain monoamine dopamine mianserin noradrenalin serotonin animal experiment autonomic nervous system biological model central nervous system drug comparison drug efficacy intraperitoneal drug administration methodology nonhuman rat Animalia Rattus norvegicus In male Wistar rats intraperitoneal injection (21 days) of mianserin, a tetracyclic antidepressant (10 mg/kg), produced significant dimunition (p < 0.01) of brain noradrenaline content without any changes in dopamine or serotonin content. Amoxapine, a tricyclic antidepressant with a potent inhibitory action of catecholamine presynaptic uptake (10 mg/kg i.p.), did not produce any changes in brain monoamine content. During the experiments the rats treated with mianserin were more quiet than the controls and remained crowded together. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03056651_v11_n9_p838_Cicardo
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic amoxapine
brain monoamine
dopamine
mianserin
noradrenalin
serotonin
animal experiment
autonomic nervous system
biological model
central nervous system
drug comparison
drug efficacy
intraperitoneal drug administration
methodology
nonhuman
rat
Animalia
Rattus norvegicus
spellingShingle amoxapine
brain monoamine
dopamine
mianserin
noradrenalin
serotonin
animal experiment
autonomic nervous system
biological model
central nervous system
drug comparison
drug efficacy
intraperitoneal drug administration
methodology
nonhuman
rat
Animalia
Rattus norvegicus
Cicardo, V.H.
Carneiro de Rondina, D.
Mastronardi, I.O.
Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine
topic_facet amoxapine
brain monoamine
dopamine
mianserin
noradrenalin
serotonin
animal experiment
autonomic nervous system
biological model
central nervous system
drug comparison
drug efficacy
intraperitoneal drug administration
methodology
nonhuman
rat
Animalia
Rattus norvegicus
description In male Wistar rats intraperitoneal injection (21 days) of mianserin, a tetracyclic antidepressant (10 mg/kg), produced significant dimunition (p < 0.01) of brain noradrenaline content without any changes in dopamine or serotonin content. Amoxapine, a tricyclic antidepressant with a potent inhibitory action of catecholamine presynaptic uptake (10 mg/kg i.p.), did not produce any changes in brain monoamine content. During the experiments the rats treated with mianserin were more quiet than the controls and remained crowded together.
format JOUR
author Cicardo, V.H.
Carneiro de Rondina, D.
Mastronardi, I.O.
author_facet Cicardo, V.H.
Carneiro de Rondina, D.
Mastronardi, I.O.
author_sort Cicardo, V.H.
title Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine
title_short Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine
title_full Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine
title_fullStr Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine
title_full_unstemmed Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine
title_sort brain monoamine content in rats treated with the antidepressants mianserin and amoxapine
url http://hdl.handle.net/20.500.12110/paper_03056651_v11_n9_p838_Cicardo
work_keys_str_mv AT cicardovh brainmonoaminecontentinratstreatedwiththeantidepressantsmianserinandamoxapine
AT carneiroderondinad brainmonoaminecontentinratstreatedwiththeantidepressantsmianserinandamoxapine
AT mastronardiio brainmonoaminecontentinratstreatedwiththeantidepressantsmianserinandamoxapine
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