Low-pH-induced fusion of Vero cells infected with Junin virus

Junin virus (JV) infected Veto cells were used to investigate virus capacity to induce cell cell fusion. Polykaryocyte formation due to JV was found to be pH and temperature-dependent. A reduced fusion activity was detected on BHK-21 cells. Different JV-strains exhibited a similar extent and pH depe...

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Detalles Bibliográficos
Autores principales: Castilla, V., Mersich, S.E.
Formato: JOUR
Materias:
Animalia
Cercopithecus
Junin virus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03048608_v141_n7_p1307_Castilla
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_03048608_v141_n7_p1307_Castilla
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spelling todo:paper_03048608_v141_n7_p1307_Castilla2023-10-03T15:20:56Z Low-pH-induced fusion of Vero cells infected with Junin virus Castilla, V. Mersich, S.E. Animalia Cercopithecus Junin virus Junin virus (JV) infected Veto cells were used to investigate virus capacity to induce cell cell fusion. Polykaryocyte formation due to JV was found to be pH and temperature-dependent. A reduced fusion activity was detected on BHK-21 cells. Different JV-strains exhibited a similar extent and pH dependence of their fusion activity. Neutralizing antibodies against the main viral glycoprotein (GP38) inhibited syncytium production and GP38 conformational changes in response to acid treatment were detected by an immunoprecipitation assay. Fil:Castilla, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Mersich, S.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03048608_v141_n7_p1307_Castilla
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Animalia
Cercopithecus
Junin virus
spellingShingle Animalia
Cercopithecus
Junin virus
Castilla, V.
Mersich, S.E.
Low-pH-induced fusion of Vero cells infected with Junin virus
topic_facet Animalia
Cercopithecus
Junin virus
description Junin virus (JV) infected Veto cells were used to investigate virus capacity to induce cell cell fusion. Polykaryocyte formation due to JV was found to be pH and temperature-dependent. A reduced fusion activity was detected on BHK-21 cells. Different JV-strains exhibited a similar extent and pH dependence of their fusion activity. Neutralizing antibodies against the main viral glycoprotein (GP38) inhibited syncytium production and GP38 conformational changes in response to acid treatment were detected by an immunoprecipitation assay.
format JOUR
author Castilla, V.
Mersich, S.E.
author_facet Castilla, V.
Mersich, S.E.
author_sort Castilla, V.
title Low-pH-induced fusion of Vero cells infected with Junin virus
title_short Low-pH-induced fusion of Vero cells infected with Junin virus
title_full Low-pH-induced fusion of Vero cells infected with Junin virus
title_fullStr Low-pH-induced fusion of Vero cells infected with Junin virus
title_full_unstemmed Low-pH-induced fusion of Vero cells infected with Junin virus
title_sort low-ph-induced fusion of vero cells infected with junin virus
url http://hdl.handle.net/20.500.12110/paper_03048608_v141_n7_p1307_Castilla
work_keys_str_mv AT castillav lowphinducedfusionofverocellsinfectedwithjuninvirus
AT mersichse lowphinducedfusionofverocellsinfectedwithjuninvirus
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